parbendazole-4357 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the parbendazole-4357 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY9 adenylate cyclase 9
AFF3 AF4/FMR2 family, member 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANK1 ankyrin 1, erythrocytic
APOL6 apolipoprotein L, 6
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATN1 atrophin 1
BIN1 bridging integrator 1
BTBD7 BTB (POZ) domain containing 7
C19ORF26 chromosome 19 open reading frame 26
C7ORF69 chromosome 7 open reading frame 69
CALB1 calbindin 1, 28kDa
CCL2 chemokine (C-C motif) ligand 2
CCNJL cyclin J-like
CD1E CD1e molecule
CD53 CD53 molecule
CDON cell adhesion associated, oncogene regulated
CFB complement factor B
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLTC clathrin, heavy chain (Hc)
CNR2 cannabinoid receptor 2 (macrophage)
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DAPK1 death-associated protein kinase 1
DIO2 deiodinase, iodothyronine, type II
DOCK6 dedicator of cytokinesis 6
EDA2R ectodysplasin A2 receptor
EHD2 EH-domain containing 2
ELOVL5 ELOVL fatty acid elongase 5
EMC3 ER membrane protein complex subunit 3
FAM182B family with sequence similarity 182, member B
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
GGT1 gamma-glutamyltransferase 1
GLRA1 glycine receptor, alpha 1
GLYAT glycine-N-acyltransferase
GP1BB glycoprotein Ib (platelet), beta polypeptide
GPR4 G protein-coupled receptor 4
H2AFX H2A histone family, member X
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
ICOSLG inducible T-cell co-stimulator ligand
IFI6 interferon, alpha-inducible protein 6
IGLJ3 immunoglobulin lambda joining 3
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIF13A kinesin family member 13A
KIF25 kinesin family member 25
KLHDC8A kelch domain containing 8A
KRT15 keratin 15, type I
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAPK8 mitogen-activated protein kinase 8
MBD2 methyl-CpG binding domain protein 2
MEF2D myocyte enhancer factor 2D
MSR1 macrophage scavenger receptor 1
MT1G metallothionein 1G
MXD4 MAX dimerization protein 4
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NKX2-5 NK2 homeobox 5
NLGN4X neuroligin 4, X-linked
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PALM paralemmin
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PKP1 plakophilin 1
PLCL2 phospholipase C-like 2
PLXDC1 plexin domain containing 1
PNPLA3 patatin-like phospholipase domain containing 3
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RHO rhodopsin
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC43A3 solute carrier family 43, member 3
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SSX3 synovial sarcoma, X breakpoint 3
TBC1D29 TBC1 domain family, member 29
TBRG4 transforming growth factor beta regulator 4
TBX3 T-box 3
TBXA2R thromboxane A2 receptor
THPO thrombopoietin
TMPRSS6 transmembrane protease, serine 6
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TTC38 tetratricopeptide repeat domain 38
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UTS2 urotensin 2
WSCD1 WSC domain containing 1
ZC4H2 zinc finger, C4H2 domain containing
ZG16 zymogen granule protein 16

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACTL8 actin-like 8
AMT aminomethyltransferase
ANP32A-IT1 ANP32A intronic transcript 1
ATAD5 ATPase family, AAA domain containing 5
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BAHCC1 BAH domain and coiled-coil containing 1
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CEP85 centrosomal protein 85kDa
CHKB choline kinase beta
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CNGB3 cyclic nucleotide gated channel beta 3
CORO7 coronin 7
CRYBB2P1 crystallin, beta B2 pseudogene 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DBF4B DBF4 zinc finger B
DCAF13 DDB1 and CUL4 associated factor 13
DGKE diacylglycerol kinase, epsilon 64kDa
DUSP8 dual specificity phosphatase 8
EFNA3 ephrin-A3
F2R coagulation factor II (thrombin) receptor
FBRS fibrosin
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGL1 fibrinogen-like 1
GAS2 growth arrest-specific 2
GLTSCR1 glioma tumor suppressor candidate region gene 1
GUSBP3 glucuronidase, beta pseudogene 3
HDAC5 histone deacetylase 5
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H2AM histone cluster 1, H2am
IQCG IQ motif containing G
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KRT16 keratin 16, type I
LINC00115 long intergenic non-protein coding RNA 115
LOC257152 uncharacterized LOC257152
LYRM9 LYR motif containing 9
MBOAT2 membrane bound O-acyltransferase domain containing 2
MOSPD3 motile sperm domain containing 3
MTCP1 mature T-cell proliferation 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5E 5'-nucleotidase, ecto (CD73)
NXPH4 neurexophilin 4
OLFML2A olfactomedin-like 2A
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OVGP1 oviductal glycoprotein 1, 120kDa
PCDHB8 protocadherin beta 8
PICK1 protein interacting with PRKCA 1
PITX2 paired-like homeodomain 2
PMCH pro-melanin-concentrating hormone
PODNL1 podocan-like 1
PORCN porcupine homolog (Drosophila)
PPT2 palmitoyl-protein thioesterase 2
QPCT glutaminyl-peptide cyclotransferase
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPL23AP32 ribosomal protein L23a pseudogene 32
SAYSD1 SAYSVFN motif domain containing 1
SCARA3 scavenger receptor class A, member 3
SETD1B SET domain containing 1B
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SOWAHC sosondowah ankyrin repeat domain family member C
SPRYD7 SPRY domain containing 7
SRD5A3 steroid 5 alpha-reductase 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TBC1D19 TBC1 domain family, member 19
TCHH trichohyalin
TESC tescalcin
THBS3 thrombospondin 3
THNSL2 threonine synthase-like 2 (S. cerevisiae)
THRAP3 thyroid hormone receptor associated protein 3
TMEM183A transmembrane protein 183A
TMEM209 transmembrane protein 209
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTBK2 tau tubulin kinase 2
TWF2 twinfilin actin binding protein 2
ZBTB25 zinc finger and BTB domain containing 25
ZNF134 zinc finger protein 134
ZNF37BP zinc finger protein 37B, pseudogene
ZNF428 zinc finger protein 428
ZNF432 zinc finger protein 432
ZNF571 zinc finger protein 571
ZNF623 zinc finger protein 623
ZNF778 zinc finger protein 778
ZNRD1-AS1 ZNRD1 antisense RNA 1