pargyline-2265 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the pargyline-2265 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ADGRF5 adhesion G protein-coupled receptor F5
AKAP8L A kinase (PRKA) anchor protein 8-like
ANP32A-IT1 ANP32A intronic transcript 1
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ASCL1 achaete-scute family bHLH transcription factor 1
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BMP10 bone morphogenetic protein 10
BMP2K BMP2 inducible kinase
BMP8A bone morphogenetic protein 8a
CCL19 chemokine (C-C motif) ligand 19
CDK19 cyclin-dependent kinase 19
CDO1 cysteine dioxygenase type 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLCA2 chloride channel accessory 2
CLIC5 chloride intracellular channel 5
CNTD2 cyclin N-terminal domain containing 2
CRMP1 collapsin response mediator protein 1
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
DCBLD2 discoidin, CUB and LCCL domain containing 2
DENND3 DENN/MADD domain containing 3
DES desmin
DNASE1 deoxyribonuclease I
DOCK3 dedicator of cytokinesis 3
EFNA5 ephrin-A5
ELOVL5 ELOVL fatty acid elongase 5
EN1 engrailed homeobox 1
FBLN1 fibulin 1
FGF4 fibroblast growth factor 4
FST follistatin
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAL3ST4 galactose-3-O-sulfotransferase 4
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2
GM2A GM2 ganglioside activator
GPATCH4 G patch domain containing 4
HAMP hepcidin antimicrobial peptide
HBB hemoglobin, beta
HIF3A hypoxia inducible factor 3, alpha subunit
HYAL1 hyaluronoglucosaminidase 1
IL1RN interleukin 1 receptor antagonist
IRAK3 interleukin-1 receptor-associated kinase 3
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JMJD6 jumonji domain containing 6
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA1024 KIAA1024
LGALS8 lectin, galactoside-binding, soluble, 8
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LINC00652 long intergenic non-protein coding RNA 652
MAP2K5 mitogen-activated protein kinase kinase 5
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MINK1 misshapen-like kinase 1
MIP major intrinsic protein of lens fiber
MOGAT2 monoacylglycerol O-acyltransferase 2
MSR1 macrophage scavenger receptor 1
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NPPA natriuretic peptide A
OMD osteomodulin
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PLA2G2E phospholipase A2, group IIE
PODNL1 podocan-like 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRB1 proline-rich protein BstNI subfamily 1
PRB4 proline-rich protein BstNI subfamily 4
PRKG2 protein kinase, cGMP-dependent, type II
PRTN3 proteinase 3
PRX periaxin
PTCH1 patched 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RHOH ras homolog family member H
RORA RAR-related orphan receptor A
RUNX1 runt-related transcription factor 1
SCAND2P SCAN domain containing 2 pseudogene
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLIT1 slit homolog 1 (Drosophila)
SMR3A submaxillary gland androgen regulated protein 3A
SOAT2 sterol O-acyltransferase 2
SOCS3 suppressor of cytokine signaling 3
SOX10 SRY (sex determining region Y)-box 10
SOX2 SRY (sex determining region Y)-box 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRGN serglycin
TBRG4 transforming growth factor beta regulator 4
TBX5 T-box 5
TEF thyrotrophic embryonic factor
TEX15 testis expressed 15
THRB thyroid hormone receptor, beta
TM4SF4 transmembrane 4 L six family member 4
TMEM63A transmembrane protein 63A
TNNI3 troponin I type 3 (cardiac)
TP53I11 tumor protein p53 inducible protein 11
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPV6 transient receptor potential cation channel, subfamily V, member 6
USP2 ubiquitin specific peptidase 2

decreased expression

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
AEN apoptosis enhancing nuclease
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARHGAP4 Rho GTPase activating protein 4
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARSB arylsulfatase B
C22ORF46 chromosome 22 open reading frame 46
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAPN15 calpain 15
CDK20 cyclin-dependent kinase 20
CDK3 cyclin-dependent kinase 3
CRABP1 cellular retinoic acid binding protein 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DGKE diacylglycerol kinase, epsilon 64kDa
DIXDC1 DIX domain containing 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EGFL7 EGF-like-domain, multiple 7
EML4 echinoderm microtubule associated protein like 4
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERCC6 excision repair cross-complementation group 6
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ETNK2 ethanolamine kinase 2
FAM186A family with sequence similarity 186, member A
FBXL15 F-box and leucine-rich repeat protein 15
FBXO31 F-box protein 31
FCHSD2 FCH and double SH3 domains 2
FGD1 FYVE, RhoGEF and PH domain containing 1
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GSAP gamma-secretase activating protein
GUSBP3 glucuronidase, beta pseudogene 3
HLA-DMA major histocompatibility complex, class II, DM alpha
HOXA4 homeobox A4
IFT140 intraflagellar transport 140
IFT22 intraflagellar transport 22
IL12RB1 interleukin 12 receptor, beta 1
KIAA0319L KIAA0319-like
KIF13B kinesin family member 13B
LY6G6C lymphocyte antigen 6 complex, locus G6C
MBNL3 muscleblind-like splicing regulator 3
MFAP2 microfibrillar-associated protein 2
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NLRX1 NLR family member X1
NOD1 nucleotide-binding oligomerization domain containing 1
NPTX1 neuronal pentraxin I
OSMR oncostatin M receptor
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PARD6A par-6 family cell polarity regulator alpha
PCSK7 proprotein convertase subtilisin/kexin type 7
PEX26 peroxisomal biogenesis factor 26
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POLL polymerase (DNA directed), lambda
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PTPRU protein tyrosine phosphatase, receptor type, U
RGS19 regulator of G-protein signaling 19
RHOBTB2 Rho-related BTB domain containing 2
RNF170 ring finger protein 170
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SAYSD1 SAYSVFN motif domain containing 1
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLIT2 slit homolog 2 (Drosophila)
SMIM14 small integral membrane protein 14
SRPX sushi-repeat containing protein, X-linked
STK16 serine/threonine kinase 16
STRA6 stimulated by retinoic acid 6
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBC1D17 TBC1 domain family, member 17
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIGD6 tigger transposable element derived 6
TMEM242 transmembrane protein 242
TMPRSS4 transmembrane protease, serine 4
TWF2 twinfilin actin binding protein 2
USP19 ubiquitin specific peptidase 19
USP27X ubiquitin specific peptidase 27, X-linked
USP6NL USP6 N-terminal like
WDR4 WD repeat domain 4
WFDC2 WAP four-disulfide core domain 2
ZNF134 zinc finger protein 134
ZNF365 zinc finger protein 365
ZNF623 zinc finger protein 623
ZNF76 zinc finger protein 76
ZNF862 zinc finger protein 862
ZSCAN26 zinc finger and SCAN domain containing 26