parkinson's disease Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions. (Human Disease Ontology, DOID_14330)
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Genes

254 genes associated with the disease parkinson's disease in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
A2M alpha-2-macroglobulin
AAK1 AP2 associated kinase 1
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ACMSD aminocarboxymuconate semialdehyde decarboxylase
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ADORA2A adenosine A2a receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APOE apolipoprotein E
ARNT aryl hydrocarbon receptor nuclear translocator
ASCL1 achaete-scute family bHLH transcription factor 1
ATP13A2 ATPase type 13A2
ATXN1 ataxin 1
ATXN2 ataxin 2
ATXN3 ataxin 3
B2M beta-2-microglobulin
BAD BCL2-associated agonist of cell death
BAX BCL2-associated X protein
BDNF brain-derived neurotrophic factor
BMP4 bone morphogenetic protein 4
BST1 bone marrow stromal cell antigen 1
C10ORF32 chromosome 10 open reading frame 32
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CALB1 calbindin 1, 28kDa
CAPN2 calpain 2, (m/II) large subunit
CAST calpastatin
CBS cystathionine-beta-synthase
CCDC62 coiled-coil domain containing 62
CCK cholecystokinin
CCKAR cholecystokinin A receptor
CCKBR cholecystokinin B receptor
CDC42 cell division cycle 42
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
COLGALT2 collagen beta(1-O)galactosyltransferase 2
COMT catechol-O-methyltransferase
COX1
COX2
CP ceruloplasmin (ferroxidase)
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRHR1-IT1 CRHR1 intronic transcript 1
CRYZ crystallin, zeta (quinone reductase)
CSF1R colony stimulating factor 1 receptor
CTSD cathepsin D
CXCL8 chemokine (C-X-C motif) ligand 8
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DCC DCC netrin 1 receptor
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DGKQ diacylglycerol kinase, theta 110kDa
DLG2 discs, large homolog 2 (Drosophila)
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
EFNA5 ephrin-A5
ELAVL4 ELAV like neuron-specific RNA binding protein 4
EN1 engrailed homeobox 1
EN2 engrailed homeobox 2
EPHA4 EPH receptor A4
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBXO7 F-box protein 7
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FGF20 fibroblast growth factor 20
FMR1 fragile X mental retardation 1
FRAXA fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)
FRAXE fragile site, folic acid type, rare, fra(X)(q28) E
FTH1 ferritin, heavy polypeptide 1
FTL ferritin, light polypeptide
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FUT2 fucosyltransferase 2 (secretor status included)
FYN FYN proto-oncogene, Src family tyrosine kinase
GAK cyclin G associated kinase
GATA2 GATA binding protein 2
GBA glucosidase, beta, acid
GCH1 GTP cyclohydrolase 1
GIGYF2 GRB10 interacting GYF protein 2
GLUD2 glutamate dehydrogenase 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRN granulin
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTO1 glutathione S-transferase omega 1
GSTO2 glutathione S-transferase omega 2
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GSTZ1 glutathione S-transferase zeta 1
HDAC6 histone deacetylase 6
HFE hemochromatosis
HIP1R huntingtin interacting protein 1 related
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
HOMER1 homer scaffolding protein 1
HP haptoglobin
HRH1 histamine receptor H1
HS1BP3 HCLS1 binding protein 3
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA9 heat shock 70kDa protein 9 (mortalin)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTRA2 HtrA serine peptidase 2
HTT huntingtin
IFNG interferon, gamma
IGF2 insulin-like growth factor 2
IL10 interleukin 10
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL4 interleukin 4
IL6 interleukin 6
INS insulin
IPO5 importin 5
ISM1 isthmin 1, angiogenesis inhibitor
ITGA8 integrin, alpha 8
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KANSL1 KAT8 regulatory NSL complex subunit 1
KEAP1 kelch-like ECH-associated protein 1
LAMP3 lysosomal-associated membrane protein 3
LINGO1 leucine rich repeat and Ig domain containing 1
LINGO2 leucine rich repeat and Ig domain containing 2
LMX1A LIM homeobox transcription factor 1, alpha
LMX1B LIM homeobox transcription factor 1, beta
LRRK2 leucine-rich repeat kinase 2
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAPT microtubule-associated protein tau
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MIR133A1 microRNA 133a-1
MIR133A2 microRNA 133a-2
MIR133B microRNA 133b
MMRN1 multimerin 1
MRAS muscle RAS oncogene homolog
MSX1 msh homeobox 1
MT-ATP6 ATP synthase F0 subunit 6
MT-ND2 MTND2
MT-ND3 NADH dehydrogenase, subunit 3 (complex I)
MT-ND5 NADH dehydrogenase, subunit 5 (complex I)
MT-TL2 tRNA
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTIF3 mitochondrial translational initiation factor 3
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NBN nibrin
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
NEFM neurofilament, medium polypeptide
NEGR1 neuronal growth regulator 1
NEUROG2 neurogenin 2
NFE2L2 nuclear factor, erythroid 2-like 2
NOD2 nucleotide-binding oligomerization domain containing 2
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NSF N-ethylmaleimide-sensitive factor
NTNG1 netrin G1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OTX2 orthodenticle homeobox 2
PACRG PARK2 co-regulated
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PARK10 Parkinson disease 10 (susceptibility)
PARK16 Parkinson disease 16 (susceptibility)
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PHACTR2 phosphatase and actin regulator 2
PHOX2B paired-like homeobox 2b
PINK1 PTEN induced putative kinase 1
PITX3 paired-like homeodomain 3
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLXNA2 plexin A2
PLXNC1 plexin C1
PM20D1 peptidase M20 domain containing 1
POLG polymerase (DNA directed), gamma
PON1 paraoxonase 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRNP prion protein
RAB29 RAB29, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RGS2 regulator of G-protein signaling 2
RNF114 ring finger protein 114
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RNR2 RNA, ribosomal cluster 2
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFXN2 sideroflexin 2
SHH sonic hedgehog
SLC41A1 solute carrier family 41 (magnesium transporter), member 1
SLC45A3 solute carrier family 45, member 3
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLIT3 slit homolog 3 (Drosophila)
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCAIP synuclein, alpha interacting protein
SOD2 superoxide dismutase 2, mitochondrial
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
STAP1 signal transducing adaptor family member 1
STBD1 starch binding domain 1
STH saitohin
STK39 serine threonine kinase 39
SYN1 synapsin I
SYT11 synaptotagmin XI
TARDBP TAR DNA binding protein
TAS1R2 taste receptor, type 1, member 2
TBP TATA box binding protein
TFAM transcription factor A, mitochondrial
TFB1M transcription factor B1, mitochondrial
TFB2M transcription factor B2, mitochondrial
TH tyrosine hydroxylase
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOR1A torsin family 1, member A (torsin A)
TPRG1 tumor protein p63 regulated 1
TRAPPC4 trafficking protein particle complex 4
TRPM7 transient receptor potential cation channel, subfamily M, member 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ULK2 unc-51 like autophagy activating kinase 2
UNC5C unc-5 homolog C (C. elegans)
USP24 ubiquitin specific peptidase 24
USP40 ubiquitin specific peptidase 40
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta