parkinsonism Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Characteristic neurologic anomaly resulting form degeneration of dopamine-generating cells in the substantia nigra, a region of the midbrain, characterized clinically by shaking, rigidity, slowness of movement and difficulty with walking and gait. (Human Phenotype Ontology, HP_0001300)
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Genes

50 genes co-occuring with the biological term parkinsonism in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACMSD aminocarboxymuconate semialdehyde decarboxylase
APP amyloid beta (A4) precursor protein
ATP13A2 ATPase type 13A2
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATXN2 ataxin 2
ATXN3 ataxin 3
ATXN8OS ATXN8 opposite strand (non-protein coding)
C10ORF2 chromosome 10 open reading frame 2
C9ORF72 chromosome 9 open reading frame 72
CHAT choline O-acetyltransferase
CSF1R colony stimulating factor 1 receptor
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSC3 desmocollin 3
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
FBXO7 F-box protein 7
FMR1 fragile X mental retardation 1
GBA glucosidase, beta, acid
GCH1 GTP cyclohydrolase 1
GRN granulin
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
LRRK2 leucine-rich repeat kinase 2
MAPT microtubule-associated protein tau
MECP2 methyl CpG binding protein 2
MT-TI tRNA
NEFL neurofilament, light polypeptide
NOTCH3 notch 3
PACRG PARK2 co-regulated
PANK2 pantothenate kinase 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PINK1 PTEN induced putative kinase 1
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
POLG polymerase (DNA directed), gamma
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRNP prion protein
PSEN1 presenilin 1
RGS2 regulator of G-protein signaling 2
SCN9A sodium channel, voltage gated, type IX alpha subunit
SEPT5 septin 5
SLC30A10 solute carrier family 30, member 10
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPG11 spastic paraplegia 11 (autosomal recessive)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SYNJ1 synaptojanin 1
TARDBP TAR DNA binding protein
TBP TATA box binding protein
TNF tumor necrosis factor
ZFPM2 zinc finger protein, FOG family member 2
ZFYVE26 zinc finger, FYVE domain containing 26