parkinsons Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)|A neurodegenerative disease that results_from degeneration of the central nervous system that often impairs the sufferer's motor skills, speech, and other functions. (Experimental Factor Ontology, EFO_0002508)
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Genes

296 genes co-occuring with the biological term parkinsons in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACE angiotensin I converting enzyme
ACHE acetylcholinesterase (Yt blood group)
ADORA2A adenosine A2a receptor
AGER advanced glycosylation end product-specific receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANG angiogenin, ribonuclease, RNase A family, 5
APCS amyloid P component, serum
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOA1 apolipoprotein A-I
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASCL1 achaete-scute family bHLH transcription factor 1
ASIC2 acid sensing (proton gated) ion channel 2
ATF4 activating transcription factor 4
ATG5 autophagy related 5
ATP13A2 ATPase type 13A2
ATXN2 ataxin 2
ATXN3 ataxin 3
ATXN8 ataxin 8
ATXN8OS ATXN8 opposite strand (non-protein coding)
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BDNF brain-derived neurotrophic factor
BST1 bone marrow stromal cell antigen 1
C3 complement component 3
C9ORF72 chromosome 9 open reading frame 72
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CALB1 calbindin 1, 28kDa
CAPN1 calpain 1, (mu/I) large subunit
CAST calpastatin
CCDC62 coiled-coil domain containing 62
CCK cholecystokinin
CCKAR cholecystokinin A receptor
CCKBR cholecystokinin B receptor
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CCL5 chemokine (C-C motif) ligand 5
CD14 CD14 molecule
CD200 CD200 molecule
CD200R1 CD200 receptor 1
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDNF cerebral dopamine neurotrophic factor
CFH complement factor H
CHMP2B charged multivesicular body protein 2B
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CLOCK clock circadian regulator
CLU clusterin
CNR1 cannabinoid receptor 1 (brain)
COMT catechol-O-methyltransferase
CP ceruloplasmin (ferroxidase)
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRP C-reactive protein, pentraxin-related
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DAPK1 death-associated protein kinase 1
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
E2F1 E2F transcription factor 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELAVL4 ELAV like neuron-specific RNA binding protein 4
EN1 engrailed homeobox 1
EN2 engrailed homeobox 2
ENDOG endonuclease G
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPHX2 epoxide hydrolase 2, cytoplasmic
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F2 coagulation factor II (thrombin)
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FBXO7 F-box protein 7
FGB fibrinogen beta chain
FGF20 fibroblast growth factor 20
FGG fibrinogen gamma chain
FMR1 fragile X mental retardation 1
FRAXA fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)
FRAXE fragile site, folic acid type, rare, fra(X)(q28) E
FTMT ferritin mitochondrial
FUS FUS RNA binding protein
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAK cyclin G associated kinase
GBA glucosidase, beta, acid
GCH1 GTP cyclohydrolase 1
GDNF glial cell derived neurotrophic factor
GFAP glial fibrillary acidic protein
GH1 growth hormone 1
GIGYF2 GRB10 interacting GYF protein 2
GLA galactosidase, alpha
GLUD2 glutamate dehydrogenase 2
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPX1 glutathione peroxidase 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRK5 G protein-coupled receptor kinase 5
GRM5 glutamate receptor, metabotropic 5
GRN granulin
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HCRT hypocretin (orexin) neuropeptide precursor
HFE hemochromatosis
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HMOX2 heme oxygenase 2
HNMT histamine N-methyltransferase
HP haptoglobin
HRH3 histamine receptor H3
HRH4 histamine receptor H4
HSP90AB2P heat shock protein 90kDa alpha (cytosolic), class B member 2, pseudogene
HSPA4 heat shock 70kDa protein 4
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTRA2 HtrA serine peptidase 2
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IL13RA1 interleukin 13 receptor, alpha 1
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
INS insulin
LAMP2 lysosomal-associated membrane protein 2
LINGO1 leucine rich repeat and Ig domain containing 1
LINGO2 leucine rich repeat and Ig domain containing 2
LMX1A LIM homeobox transcription factor 1, alpha
LMX1B LIM homeobox transcription factor 1, beta
LPO lactoperoxidase
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRRK1 leucine-rich repeat kinase 1
LRRK2 leucine-rich repeat kinase 2
LY6E lymphocyte antigen 6 complex, locus E
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAPT microtubule-associated protein tau
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MEF2C myocyte enhancer factor 2C
MEF2D myocyte enhancer factor 2D
MIR133B microRNA 133b
MIR205 microRNA 205
MIR433 microRNA 433
MIR7-1 microRNA 7-1
MIR7-2 microRNA 7-2
MIR7-3 microRNA 7-3
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MMP9 matrix metallopeptidase 9
MT-ND2 MTND2
MT-ND5 NADH dehydrogenase, subunit 5 (complex I)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTIF3 mitochondrial translational initiation factor 3
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
ND1
NDFIP1 Nedd4 family interacting protein 1
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFL neurofilament, light polypeptide
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOD2 nucleotide-binding oligomerization domain containing 2
NPTX2 neuronal pentraxin II
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRG1 neuregulin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OGG1 8-oxoguanine DNA glycosylase
OTX2 orthodenticle homeobox 2
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PACRG PARK2 co-regulated
PARK12 Parkinson disease 12 (susceptibility)
PARK16 Parkinson disease 16 (susceptibility)
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK3 Parkinson disease 3 (autosomal dominant, Lewy body)
PARK7 parkinson protein 7
PARL presenilin associated, rhomboid-like
PARP1 poly (ADP-ribose) polymerase 1
PAWR PRKC, apoptosis, WT1, regulator
PDYN prodynorphin
PER1 period circadian clock 1
PHACTR2 phosphatase and actin regulator 2
PICALM phosphatidylinositol binding clathrin assembly protein
PINK1 PTEN induced putative kinase 1
PITX3 paired-like homeodomain 3
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLXNA4 plexin A4
PMEL premelanosome protein
POLG polymerase (DNA directed), gamma
PON1 paraoxonase 1
PON2 paraoxonase 2
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPHLN1 periphilin 1
PRDX2 peroxiredoxin 2
PRDX3 peroxiredoxin 3
PRDX5 peroxiredoxin 5
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
PVALB parvalbumin
RAB29 RAB29, member RAS oncogene family
RET ret proto-oncogene
RIT2 Ras-like without CAAX 2
RNF11 ring finger protein 11
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RPS15 ribosomal protein S15
RTN3 reticulon 3
S100B S100 calcium binding protein B
SCARB2 scavenger receptor class B, member 2
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIRT2 sirtuin 2
SIRT5 sirtuin 5
SKP1 S-phase kinase-associated protein 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC41A1 solute carrier family 41 (magnesium transporter), member 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCAIP synuclein, alpha interacting protein
SNCB synuclein, beta
SOD1 superoxide dismutase 1, soluble
SPP1 secreted phosphoprotein 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRF serum response factor (c-fos serum response element-binding transcription factor)
SST somatostatin
STH saitohin
STX6 syntaxin 6
SYT11 synaptotagmin XI
TARDBP TAR DNA binding protein
TBP TATA box binding protein
TF transferrin
TFAM transcription factor A, mitochondrial
TFR2 transferrin receptor 2
TFRC transferrin receptor
TGM2 transglutaminase 2
TH tyrosine hydroxylase
TIMP1 TIMP metallopeptidase inhibitor 1
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TP53 tumor protein p53
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TREM2 triggering receptor expressed on myeloid cells 2
TSC2 tuberous sclerosis 2
TTR transthyretin
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
VCP valosin containing protein
VDAC1 voltage-dependent anion channel 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae)
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
WWOX WW domain containing oxidoreductase
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta