parp1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description poly (ADP-ribose) polymerase 1|This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 142)
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Genes

138 genes co-occuring with the biological term parp1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOD apolipoprotein D
APTX aprataxin
ATM ATM serine/threonine kinase
AURKB aurora kinase B
BAG1 BCL2-associated athanogene
BCL2 B-cell CLL/lymphoma 2
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CARD10 caspase recruitment domain family, member 10
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBX5 chromobox homolog 5
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPB centromere protein B, 80kDa
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CHD1L chromodomain helicase DNA binding protein 1-like
CHEK1 checkpoint kinase 1
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CREBBP CREB binding protein
CST3 cystatin C
CTCF CCCTC-binding factor (zinc finger protein)
CTSB cathepsin B
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTX3L deltex 3 like, E3 ubiquitin ligase
DYX1C1 dyslexia susceptibility 1 candidate 1
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC2 excision repair cross-complementation group 2
ERCC6 excision repair cross-complementation group 6
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBN1 fibrillin 1
FOXO1 forkhead box O1
GTF2I general transcription factor IIi
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
H2AFX H2A histone family, member X
H2AFY H2A histone family, member Y
HES1 hes family bHLH transcription factor 1
HFE hemochromatosis
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL10 interleukin 10
IL1A interleukin 1, alpha
IL6 interleukin 6
ILK integrin-linked kinase
KDM5B lysine (K)-specific demethylase 5B
KLF8 Kruppel-like factor 8
LGALS3 lectin, galactoside-binding, soluble, 3
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPT microtubule-associated protein tau
MDC1 mediator of DNA-damage checkpoint 1
MGMT O-6-methylguanine-DNA methyltransferase
MIR223 microRNA 223
MIRLET7A2 microRNA let-7a-2
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH2 mutS homolog 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTUS1 microtubule associated tumor suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NCAPD2 non-SMC condensin I complex, subunit D2
NCAPH non-SMC condensin I complex, subunit H
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NKX2-1 NK2 homeobox 1
NMNAT1 nicotinamide nucleotide adenylyltransferase 1
NOS2 nitric oxide synthase 2, inducible
NR1H4 nuclear receptor subfamily 1, group H, member 4
NRF1 nuclear respiratory factor 1
OGG1 8-oxoguanine DNA glycosylase
PARG poly (ADP-ribose) glycohydrolase
PARP1 poly (ADP-ribose) polymerase 1
PARP10 poly (ADP-ribose) polymerase family, member 10
PARP2 poly (ADP-ribose) polymerase 2
PARP3 poly (ADP-ribose) polymerase family, member 3
PARP4 poly (ADP-ribose) polymerase family, member 4
PARP9 poly (ADP-ribose) polymerase family, member 9
PARPBP PARP1 binding protein
PAX6 paired box 6
PAX8 paired box 8
PCNA proliferating cell nuclear antigen
PHEX phosphate regulating endopeptidase homolog, X-linked
PNKP polynucleotide kinase 3'-phosphatase
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD18 RAD18 E3 ubiquitin protein ligase
RECQL RecQ helicase-like
RECQL4 RecQ protein-like 4
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOB ras homolog family member B
SET SET nuclear proto-oncogene
SFPQ splicing factor proline/glutamine-rich
SFTPB surfactant protein B
SH3BP2 SH3-domain binding protein 2
SIRT1 sirtuin 1
SIRT6 sirtuin 6
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TNF tumor necrosis factor
TOP1 topoisomerase (DNA) I
TOP2B topoisomerase (DNA) II beta 180kDa
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TREX1 three prime repair exonuclease 1
TRIM28 tripartite motif containing 28
TRPM2 transient receptor potential cation channel, subfamily M, member 2
WRN Werner syndrome, RecQ helicase-like
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6