parthenolide-1736 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the parthenolide-1736 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ADAM10 ADAM metallopeptidase domain 10
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AVL9 AVL9 homolog (S. cerevisiase)
BAG3 BCL2-associated athanogene 3
BANP BTG3 associated nuclear protein
BCL6 B-cell CLL/lymphoma 6
BUD31 BUD31 homolog (S. cerevisiae)
C18ORF25 chromosome 18 open reading frame 25
CANT1 calcium activated nucleotidase 1
CFLAR CASP8 and FADD-like apoptosis regulator
CLCN3 chloride channel, voltage-sensitive 3
CRYZ crystallin, zeta (quinone reductase)
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDIT3 DNA-damage-inducible transcript 3
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EIF5 eukaryotic translation initiation factor 5
FAM53C family with sequence similarity 53, member C
GABARAPL1 GABA(A) receptor-associated protein like 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GCLM glutamate-cysteine ligase, modifier subunit
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GGPS1 geranylgeranyl diphosphate synthase 1
GNPDA1 glucosamine-6-phosphate deaminase 1
GOLGA2 golgin A2
HEXIM1 hexamethylene bis-acetamide inducible 1
HMOX1 heme oxygenase 1
HRH1 histamine receptor H1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA14 heat shock 70kDa protein 14
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IER5 immediate early response 5
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
INVS inversin
JMJD6 jumonji domain containing 6
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCTD7 potassium channel tetramerization domain containing 7
KIAA0232 KIAA0232
KLF6 Kruppel-like factor 6
KRT10 keratin 10, type I
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LOC100129361
LSM1 LSM1, U6 small nuclear RNA associated
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPKBP1 mitogen-activated protein kinase binding protein 1
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MIR22HG MIR22 host gene
MRPL18 mitochondrial ribosomal protein L18
MTF1 metal-regulatory transcription factor 1
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
MUM1 melanoma associated antigen (mutated) 1
MVK mevalonate kinase
NGRN neugrin, neurite outgrowth associated
NQO1 NAD(P)H dehydrogenase, quinone 1
NUDC nudC nuclear distribution protein
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
PAPOLA poly(A) polymerase alpha
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PKNOX1 PBX/knotted 1 homeobox 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RIT1 Ras-like without CAAX 1
RWDD2A RWD domain containing 2A
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SIDT2 SID1 transmembrane family, member 2
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX11 sorting nexin 11
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STIP1 stress-induced phosphoprotein 1
STK17A serine/threonine kinase 17a
SYT11 synaptotagmin XI
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TGIF1 TGFB-induced factor homeobox 1
TMEM161A transmembrane protein 161A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
UNKL unkempt family zinc finger-like
USP34 ubiquitin specific peptidase 34
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AHR aryl hydrocarbon receptor
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
BCOR BCL6 corepressor
BYSL bystin-like
CALHM2 calcium homeostasis modulator 2
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CCND3 cyclin D3
CCNE2 cyclin E2
CD14 CD14 molecule
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CERK ceramide kinase
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CIRBP cold inducible RNA binding protein
CISH cytokine inducible SH2-containing protein
DDB2 damage-specific DNA binding protein 2, 48kDa
DDHD2 DDHD domain containing 2
DPY19L4 dpy-19-like 4 (C. elegans)
E2F8 E2F transcription factor 8
EGR3 early growth response 3
FAM111A family with sequence similarity 111, member A
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GFI1 growth factor independent 1 transcription repressor
GOLPH3L golgi phosphoprotein 3-like
H1FX H1 histone family, member X
HCRP1 hepatocellular carcinoma-related HCRP1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HEATR3 HEAT repeat containing 3
HELLS helicase, lymphoid-specific
HILPDA hypoxia inducible lipid droplet-associated
HMHA1 histocompatibility (minor) HA-1
IER3 immediate early response 3
IL10RA interleukin 10 receptor, alpha
IRF8 interferon regulatory factor 8
IVNS1ABP influenza virus NS1A binding protein
KIF20B kinesin family member 20B
KIF21B kinesin family member 21B
LINC00341 long intergenic non-protein coding RNA 341
LTB lymphotoxin beta (TNF superfamily, member 3)
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAGEF1 melanoma antigen family F1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSL1 male-specific lethal 1 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLIP myosin regulatory light chain interacting protein
MYO1F myosin IF
NDRG1 N-myc downstream regulated 1
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NHLRC2 NHL repeat containing 2
NT5DC2 5'-nucleotidase domain containing 2
ODC1 ornithine decarboxylase 1
ORC1 origin recognition complex, subunit 1
PARG poly (ADP-ribose) glycohydrolase
PBK PDZ binding kinase
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PNOC prepronociceptin
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRDM13 PR domain containing 13
PRKCD protein kinase C, delta
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAB20 RAB20, member RAS oncogene family
RCL1 RNA terminal phosphate cyclase-like 1
REPIN1 replication initiator 1
RFC3 replication factor C (activator 1) 3, 38kDa
RGCC regulator of cell cycle
RGS13 regulator of G-protein signaling 13
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RNASE6 ribonuclease, RNase A family, k6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SGK1 serum/glucocorticoid regulated kinase 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPP1 secreted phosphoprotein 1
TFRC transferrin receptor
TJP2 tight junction protein 2
TLR2 toll-like receptor 2
TMEM168 transmembrane protein 168
TMEM243 transmembrane protein 243, mitochondrial
TNF tumor necrosis factor
TNS3 tensin 3
TOE1 target of EGR1, member 1 (nuclear)
TRAC T cell receptor alpha constant
TRIM22 tripartite motif containing 22
TRIM8 tripartite motif containing 8
TST thiosulfate sulfurtransferase (rhodanese)
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP16 ubiquitin specific peptidase 16
VSIG4 V-set and immunoglobulin domain containing 4
WWC3 WWC family member 3
XAF1 XIAP associated factor 1
XYLT1 xylosyltransferase I
YEATS2 YEATS domain containing 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZSCAN9 zinc finger and SCAN domain containing 9