pax2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description paired box 2|PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014] (NCBI Entrez Gene Database, 5076)
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Genes

33 genes co-occuring with the biological term pax2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AR androgen receptor
ATOH1 atonal homolog 1 (Drosophila)
CCND1 cyclin D1
DEFB1 defensin, beta 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
FOS FBJ murine osteosarcoma viral oncogene homolog
HAVCR1 hepatitis A virus cellular receptor 1
HNF1B HNF1 homeobox B
INHA inhibin, alpha
INHBA inhibin, beta A
JUN jun proto-oncogene
LOC647859 occludin pseudogene
MIR1225 microRNA 1225
MIR1915 microRNA 1915
MKI67 marker of proliferation Ki-67
MOK MOK protein kinase
MSLN mesothelin
NAPSA napsin A aspartic peptidase
NUPR1 nuclear protein, transcriptional regulator, 1
PAX2 paired box 2
PAX8 paired box 8
PITX2 paired-like homeodomain 2
PROM1 prominin 1
PTEN phosphatase and tensin homolog
SFRP2 secreted frizzled-related protein 2
TLR2 toll-like receptor 2
TP53 tumor protein p53
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WNT5A wingless-type MMTV integration site family, member 5A