pax5 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description paired box 5|This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 5079)
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Genes

41 genes co-occuring with the biological term pax5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ASXL1 additional sex combs like transcriptional regulator 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL6 B-cell CLL/lymphoma 6
BRCA2 breast cancer 2, early onset
CD19 CD19 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CDH13 cadherin 13
CDKN2A cyclin-dependent kinase inhibitor 2A
DAXX death-domain associated protein
DNTT DNA nucleotidylexotransferase
EBF1 early B-cell factor 1
EP300 E1A binding protein p300
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV6 ets variant 6
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FDPS farnesyl diphosphate synthase
FRG1B FSHD region gene 1 family, member B
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KIF16B kinesin family member 16B
MCOLN2 mucolipin 2
MET MET proto-oncogene, receptor tyrosine kinase
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSH6 mutS homolog 6
MUM1 melanoma associated antigen (mutated) 1
PAX5 paired box 5
PAX6 paired box 6
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PML promyelocytic leukemia
POU2AF1 POU class 2 associating factor 1
POU2F2 POU class 2 homeobox 2
PRDM1 PR domain containing 1, with ZNF domain
PTK2 protein tyrosine kinase 2
PXN paxillin
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
TP53 tumor protein p53
WT1 Wilms tumor 1
ZCCHC7 zinc finger, CCHC domain containing 7