pax6 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description paired box 6|This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] (NCBI Entrez Gene Database, 5080)
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Genes

64 genes co-occuring with the biological term pax6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ADAM10 ADAM metallopeptidase domain 10
AR androgen receptor
BMP1 bone morphogenetic protein 1
BRCA2 breast cancer 2, early onset
CCND2 cyclin D2
CDH13 cadherin 13
CRYAA crystallin, alpha A
CRYGC crystallin, gamma C
CTCF CCCTC-binding factor (zinc finger protein)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DIAPH1 diaphanous-related formin 1
DYNLL1 dynein, light chain, LC8-type 1
EGF epidermal growth factor
EMX2 empty spiracles homeobox 2
ENG endoglin
FABP7 fatty acid binding protein 7, brain
FOXE3 forkhead box E3
GCG glucagon
GIP gastric inhibitory polypeptide
GJA8 gap junction protein, alpha 8, 50kDa
GLI1 GLI family zinc finger 1
HIPK2 homeodomain interacting protein kinase 2
HOXB1 homeobox B1
JUP junction plakoglobin
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MEIS2 Meis homeobox 2
MET MET proto-oncogene, receptor tyrosine kinase
MIR10B microRNA 10b
MIR135B microRNA 135b
MIR140 microRNA 140
MIR223 microRNA 223
MIR365B microRNA 365b
MIR7-1 microRNA 7-1
MIR96 microRNA 96
MSH6 mutS homolog 6
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NANOG Nanog homeobox
OLFM3 olfactomedin 3
OTX2 orthodenticle homeobox 2
PAX5 paired box 5
PAX6 paired box 6
PBX1 pre-B-cell leukemia homeobox 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDX1 pancreatic and duodenal homeobox 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
POU2F1 POU class 2 homeobox 1
POU5F1 POU class 5 homeobox 1
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTCH1 patched 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SHH sonic hedgehog
SIX3 SIX homeobox 3
SOX2 SRY (sex determining region Y)-box 2
SOX3 SRY (sex determining region Y)-box 3
TCF20 transcription factor 20 (AR1)
TFCP2 transcription factor CP2
TGFB1 transforming growth factor, beta 1
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TRIM11 tripartite motif containing 11
WT1 Wilms tumor 1