pc3 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Human prostate carcinoma cell line; established from the bone marrow metastasis isolated post-mortem from a 62-year-old Caucasian man with grade IV prostate cancer, poorly differentiated adenocarcinoma, after androgen suppression therapy; described to form tumors in nude mice, to grow in soft agar, and to be unresponsive to androgen treatment. (Experimental Factor Ontology, EFO_0002074)
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Genes

193 genes co-occuring with the biological term pc3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ADAM15 ADAM metallopeptidase domain 15
ADAM17 ADAM metallopeptidase domain 17
ADRA1B adrenoceptor alpha 1B
AHR aryl hydrocarbon receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX15B arachidonate 15-lipoxygenase, type B
AMACR alpha-methylacyl-CoA racemase
AR androgen receptor
ARHGAP1 Rho GTPase activating protein 1
ATG5 autophagy related 5
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
C2ORF40 chromosome 2 open reading frame 40
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCR1 chemokine (C-C motif) receptor 1
CCR7 chemokine (C-C motif) receptor 7
CD151 CD151 molecule (Raph blood group)
CD276 CD276 molecule
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK9 cyclin-dependent kinase 9
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFLAR CASP8 and FADD-like apoptosis regulator
CHGA chromogranin A
CHKA choline kinase alpha
CLU clusterin
CMTM5 CKLF-like MARVEL transmembrane domain containing 5
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR6 chemokine (C-X-C motif) receptor 6
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DIABLO diablo, IAP-binding mitochondrial protein
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DUOX1 dual oxidase 1
DUOX2 dual oxidase 2
ECE1 endothelin converting enzyme 1
EGR1 early growth response 1
EPHA1 EPH receptor A1
EPHB4 EPH receptor B4
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ERGIC2 ERGIC and golgi 2
EZR ezrin
F2R coagulation factor II (thrombin) receptor
FAM65B family with sequence similarity 65, member B
FGF8 fibroblast growth factor 8 (androgen-induced)
FLNA filamin A, alpha
FLT4 fms-related tyrosine kinase 4
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO1 forkhead box O1
GDF15 growth differentiation factor 15
GDF2 growth differentiation factor 2
GDF9 growth differentiation factor 9
GJA1 gap junction protein, alpha 1, 43kDa
GLS glutaminase
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPER1 G protein-coupled estrogen receptor 1
GPNMB glycoprotein (transmembrane) nmb
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HSPB1 heat shock 27kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFNB1 interferon, beta 1, fibroblast
IGF1R insulin-like growth factor 1 receptor
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL6 interleukin 6
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INPPL1 inositol polyphosphate phosphatase-like 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA6 integrin, alpha 6
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JTB jumping translocation breakpoint
JUN jun proto-oncogene
KDR kinase insert domain receptor
KLK11 kallikrein-related peptidase 11
KLK3 kallikrein-related peptidase 3
KLK5 kallikrein-related peptidase 5
LEF1 lymphoid enhancer-binding factor 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MBD1 methyl-CpG binding domain protein 1
MECP2 methyl CpG binding protein 2
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIR133A1 microRNA 133a-1
MIR133B microRNA 133b
MIR143 microRNA 143
MIR145 microRNA 145
MIR148A microRNA 148a
MIR181B1 microRNA 181b-1
MIR181B2 microRNA 181b-2
MIR205 microRNA 205
MIR218-1 microRNA 218-1
MIR221 microRNA 221
MIR222 microRNA 222
MIR373 microRNA 373
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MST1R macrophage stimulating 1 receptor
MT1A metallothionein 1A
MT2A metallothionein 2A
MT3 metallothionein 3
MTA1 metastasis associated 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEU2 sialidase 2 (cytosolic sialidase)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGFR nerve growth factor receptor
NKX3-1 NK3 homeobox 1
NOG noggin
NOV nephroblastoma overexpressed
NPEPPS aminopeptidase puromycin sensitive
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTSR1 neurotensin receptor 1 (high affinity)
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PARM1 prostate androgen-regulated mucin-like protein 1
PARP1 poly (ADP-ribose) polymerase 1
PAWR PRKC, apoptosis, WT1, regulator
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFD platelet derived growth factor D
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PLAC8 placenta-specific 8
PMEPA1 prostate transmembrane protein, androgen induced 1
PODXL podocalyxin-like
PPARG peroxisome proliferator-activated receptor gamma
PRKCA protein kinase C, alpha
PRSS8 protease, serine, 8
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
PTK2 protein tyrosine kinase 2
PTRF polymerase I and transcript release factor
PURA purine-rich element binding protein A
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RB1CC1 RB1-inducible coiled-coil 1
RBP4 retinol binding protein 4, plasma
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOA ras homolog family member A
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RRM2 ribonucleotide reductase M2
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RXRA retinoid X receptor, alpha
S1PR5 sphingosine-1-phosphate receptor 5
SFN stratifin
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRT1 sirtuin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SP1 Sp1 transcription factor
SPHK1 sphingosine kinase 1
SPP1 secreted phosphoprotein 1
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STS steroid sulfatase (microsomal), isozyme S
TLR4 toll-like receptor 4
TMPRSS2 transmembrane protease, serine 2
TNF tumor necrosis factor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TPD52 tumor protein D52
TPM2 tropomyosin 2 (beta)
TRPC6 transient receptor potential cation channel, subfamily C, member 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
URGCP upregulator of cell proliferation
VEGFA vascular endothelial growth factor A
ZFP42 ZFP42 zinc finger protein