pcna complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation. (Gene Ontology, GO_0043626)
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Genes

37 proteins co-occuring with the pcna complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen 1.86831
RFC1 replication factor C (activator 1) 1, 145kDa 1.44968
RFC3 replication factor C (activator 1) 3, 38kDa 1.41474
RFC5 replication factor C (activator 1) 5, 36.5kDa 1.41138
RFC4 replication factor C (activator 1) 4, 37kDa 1.4097
RFC2 replication factor C (activator 1) 2, 40kDa 1.33957
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 1.23192
XPA xeroderma pigmentosum, complementation group A 1.21169
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.904138
FEN1 flap structure-specific endonuclease 1 0.714126
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 0.66164
ERCC5 excision repair cross-complementation group 5 0.659482
DMC1 DNA meiotic recombinase 1 0.598538
WISP1 WNT1 inducible signaling pathway protein 1 0.532078
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.52675
SFPQ splicing factor proline/glutamine-rich 0.515308
ATAD5 ATPase family, AAA domain containing 5 0.512862
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 0.499853
DNTT DNA nucleotidylexotransferase 0.494585
CDK2 cyclin-dependent kinase 2 0.487711
VSX2 visual system homeobox 2 0.377738
SKI SKI proto-oncogene 0.377738
MSH3 mutS homolog 3 0.360515
LIG1 ligase I, DNA, ATP-dependent 0.318205
RAD17 RAD17 homolog (S. pombe) 0.293637
ERCC2 excision repair cross-complementation group 2 0.286245
WASL Wiskott-Aldrich syndrome-like 0.285876
ERCC4 excision repair cross-complementation group 4 0.246769
CDK7 cyclin-dependent kinase 7 0.219617
CCND1 cyclin D1 0.218212
ERCC1 excision repair cross-complementation group 1 0.214017
UNG uracil-DNA glycosylase 0.194698
TP53 tumor protein p53 0.180045
RNASE3 ribonuclease, RNase A family, 3 0.172468
CDT1 chromatin licensing and DNA replication factor 1 0.167366
AICDA activation-induced cytidine deaminase 0.159268
MAPK1 mitogen-activated protein kinase 1 0.15776