pcna Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description proliferating cell nuclear antigen|The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5111)
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Genes

150 genes co-occuring with the biological term pcna in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTA2 actin, alpha 2, smooth muscle, aorta
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANAPC2 anaphase promoting complex subunit 2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATAD5 ATPase family, AAA domain containing 5
ATM ATM serine/threonine kinase
AURKA aurora kinase A
BCL2 B-cell CLL/lymphoma 2
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CA9 carbonic anhydrase IX
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBX1 chromobox homolog 1
CCND1 cyclin D1
CCND3 cyclin D3
CCNE1 cyclin E1
CD34 CD34 molecule
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK9 cyclin-dependent kinase 9
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDT1 chromatin licensing and DNA replication factor 1
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHEK1 checkpoint kinase 1
CLSPN claspin
CSNK2B casein kinase 2, beta polypeptide
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL4A cullin 4A
CUL4B cullin 4B
DDB1 damage-specific DNA binding protein 1, 127kDa
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F3 E2F transcription factor 3
EGFR epidermal growth factor receptor
ENDOG endonuclease G
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ERCC5 excision repair cross-complementation group 5
ESR1 estrogen receptor 1
FAM111A family with sequence similarity 111, member A
FANCD2 Fanconi anemia, complementation group D2
FEN1 flap structure-specific endonuclease 1
FGF2 fibroblast growth factor 2 (basic)
FLT1 fms-related tyrosine kinase 1
FXYD3 FXYD domain containing ion transport regulator 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GSK3B glycogen synthase kinase 3 beta
GSTP1 glutathione S-transferase pi 1
HIST4H4 histone cluster 4, H4
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLTF helicase-like transcription factor
HMGN1 high mobility group nucleosome binding domain 1
HSPA1A heat shock 70kDa protein 1A
HUS1 HUS1 checkpoint homolog (S. pombe)
ICAM1 intercellular adhesion molecule 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
ISG15 ISG15 ubiquitin-like modifier
KAT2B K(lysine) acetyltransferase 2B
KDR kinase insert domain receptor
KIAA0101 KIAA0101
LIG1 ligase I, DNA, ATP-dependent
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK15 mitogen-activated protein kinase 15
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MCM2 minichromosome maintenance complex component 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MUTYH mutY homolog
NCR2 natural cytotoxicity triggering receptor 2
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NET1 neuroepithelial cell transforming 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NTHL1 nth endonuclease III-like 1 (E. coli)
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
PARP1 poly (ADP-ribose) polymerase 1
PARP10 poly (ADP-ribose) polymerase family, member 10
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCNA proliferating cell nuclear antigen
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PGR progesterone receptor
POLB polymerase (DNA directed), beta
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLH polymerase (DNA directed), eta
POLI polymerase (DNA directed) iota
POLK polymerase (DNA directed) kappa
POLL polymerase (DNA directed), lambda
POLN polymerase (DNA directed) nu
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTTG1 pituitary tumor-transforming 1
PURA purine-rich element binding protein A
RAD1 RAD1 checkpoint DNA exonuclease
RAD17 RAD17 homolog (S. pombe)
RAD18 RAD18 E3 ubiquitin protein ligase
RAD23B RAD23 homolog B (S. cerevisiae)
RAD9A RAD9 homolog A (S. pombe)
RB1 retinoblastoma 1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
REV1 REV1, polymerase (DNA directed)
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPA1 replication protein A1, 70kDa
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SETD8 SET domain containing (lysine methyltransferase) 8
SHH sonic hedgehog
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase
SIVA1 SIVA1, apoptosis-inducing factor
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SPRTN SprT-like N-terminal domain
TDG thymine-DNA glycosylase
TERT telomerase reverse transcriptase
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP73 tumor protein p73
UBC ubiquitin C
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
VEGFA vascular endothelial growth factor A
VIM vimentin
WRN Werner syndrome, RecQ helicase-like
XPA xeroderma pigmentosum, complementation group A
XPO1 exportin 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YBX1 Y box binding protein 1
ZRANB3 zinc finger, RAN-binding domain containing 3