pcos Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading. (Experimental Factor Ontology, EFO_0000660)
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Genes

140 genes co-occuring with the biological term pcos in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACVR1 activin A receptor, type I
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADM adrenomedullin
AKR1C3 aldo-keto reductase family 1, member C3
AMH anti-Mullerian hormone
APOA1 apolipoprotein A-I
APOB apolipoprotein B
AQP8 aquaporin 8
AR androgen receptor
BDNF brain-derived neurotrophic factor
BGLAP bone gamma-carboxyglutamate (gla) protein
BMP15 bone morphogenetic protein 15
CAPN10 calpain 10
CCK cholecystokinin
CCL2 chemokine (C-C motif) ligand 2
CD40LG CD40 ligand
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPB2 carboxypeptidase B2 (plasma)
CRP C-reactive protein, pentraxin-related
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DENND1A DENN/MADD domain containing 1A
ENG endoglin
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FBN3 fibrillin 3
FEM1A fem-1 homolog a (C. elegans)
FEM1B fem-1 homolog b (C. elegans)
FSHR follicle stimulating hormone receptor
FST follistatin
FTO fat mass and obesity associated
GAB1 GRB2-associated binding protein 1
GATA6 GATA binding protein 6
GDF9 growth differentiation factor 9
GH1 growth hormone 1
GHR growth hormone receptor
GHRL ghrelin/obestatin prepropeptide
GPX3 glutathione peroxidase 3
GREB1 growth regulation by estrogen in breast cancer 1
GYS1 glycogen synthase 1 (muscle)
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HCRT hypocretin (orexin) neuropeptide precursor
HDAC3 histone deacetylase 3
HFE hemochromatosis
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ICAM1 intercellular adhesion molecule 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGFBP1 insulin-like growth factor binding protein 1
IL10 interleukin 10
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
IL6R interleukin 6 receptor
INHA inhibin, alpha
INHBA inhibin, beta A
INHBB inhibin, beta B
INHBC inhibin, beta C
INS insulin
INSL3 insulin-like 3 (Leydig cell)
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITLN1 intelectin 1 (galactofuranose binding)
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KISS1 KiSS-1 metastasis-suppressor
KLK3 kallikrein-related peptidase 3
LCN2 lipocalin 2
LEP leptin
LEPQTL1 Leptin, serum levels of
LHB luteinizing hormone beta polypeptide
LHCGR luteinizing hormone/choriogonadotropin receptor
LIPE lipase, hormone-sensitive
LMNA lamin A/C
LPP LIM domain containing preferred translocation partner in lipoma
MCF2L2 MCF.2 cell line derived transforming sequence-like 2
MGAM maltase-glucoamylase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP2 matrix metallopeptidase 2
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAMPT nicotinamide phosphoribosyltransferase
NCOR1 nuclear receptor corepressor 1
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPB natriuretic peptide B
NRIP1 nuclear receptor interacting protein 1
PDE8A phosphodiesterase 8A
PEPD peptidase D
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAT plasminogen activator, tissue
PNPLA2 patatin-like phospholipase domain containing 2
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRDX4 peroxiredoxin 4
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit
PTEN phosphatase and tensin homolog
PTX3 pentraxin 3, long
PYY peptide YY
RAD54B RAD54 homolog B (S. cerevisiae)
RBP4 retinol binding protein 4, plasma
RETN resistin
RUNX2 runt-related transcription factor 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SHBG sex hormone-binding globulin
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFBR3 transforming growth factor, beta receptor III
THADA thyroid adenoma associated
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIB3 tribbles pseudokinase 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A