pcsk9 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description proprotein convertase subtilisin/kexin type 9|This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] (NCBI Entrez Gene Database, 255738)
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Genes

28 genes co-occuring with the biological term pcsk9 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ANXA2 annexin A2
APLP2 amyloid beta (A4) precursor-like protein 2
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOE apolipoprotein E
APOM apolipoprotein M
BACE1 beta-site APP-cleaving enzyme 1
BIRC2 baculoviral IAP repeat containing 2
FURIN furin (paired basic amino acid cleaving enzyme)
GGT1 gamma-glutamyltransferase 1
HNF1A HNF1 homeobox A
LDLR low density lipoprotein receptor
LIPG lipase, endothelial
LPA lipoprotein, Lp(a)
LRP1 low density lipoprotein receptor-related protein 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MYLIP myosin regulatory light chain interacting protein
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
OSM oncostatin M
PCSK5 proprotein convertase subtilisin/kexin type 5
PCSK9 proprotein convertase subtilisin/kexin type 9
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PPARA peroxisome proliferator-activated receptor alpha
RETN resistin
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
VLDLR very low density lipoprotein receptor