pdgfra Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description platelet-derived growth factor receptor, alpha polypeptide|This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 5156)
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Genes

28 genes co-occuring with the biological term pdgfra in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ALK anaplastic lymphoma receptor tyrosine kinase
BRAF B-Raf proto-oncogene, serine/threonine kinase
CHGA chromogranin A
CHIC2 cysteine-rich hydrophobic domain 2
CIC capicua transcriptional repressor
DOCK1 dedicator of cytokinesis 1
E2F1 E2F transcription factor 1
EGFR epidermal growth factor receptor
FGF2 fibroblast growth factor 2 (basic)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FIP1L1 factor interacting with PAPOLA and CPSF1
FLT1 fms-related tyrosine kinase 1
GATA6 GATA binding protein 6
KDR kinase insert domain receptor
KIF5B kinesin family member 5B
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
MIR146A microRNA 146a
MIR146B microRNA 146b
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NCAM1 neural cell adhesion molecule 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
SYP synaptophysin
VEGFA vascular endothelial growth factor A