pdgfrb Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description platelet-derived growth factor receptor, beta polypeptide|This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5159)
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Genes

31 genes co-occuring with the biological term pdgfrb in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ALK anaplastic lymphoma receptor tyrosine kinase
CCDC88C coiled-coil domain containing 88C
DTD1 D-tyrosyl-tRNA deacylase 1
ETV6 ets variant 6
F3 coagulation factor III (thromboplastin, tissue factor)
FGF2 fibroblast growth factor 2 (basic)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FLT1 fms-related tyrosine kinase 1
FLT4 fms-related tyrosine kinase 4
KANK1 KN motif and ankyrin repeat domains 1
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
MMP3 matrix metallopeptidase 3
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PRKG2 protein kinase, cGMP-dependent, type II
PROX1 prospero homeobox 1
PTPRG protein tyrosine phosphatase, receptor type, G
RNF213 ring finger protein 213
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1
TIMP2 TIMP metallopeptidase inhibitor 2
TP53 tumor protein p53
TP73 tumor protein p73
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1