pdk2 Gene Set

Dataset	GeneRIF Biological Term Annotations
Category	structural or functional annotations
Type	biological term
Description	pyruvate dehydrogenase kinase, isozyme 2\|This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] (NCBI Entrez Gene Database, 5164)
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Genes

11 genes co-occuring with the biological term pdk2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol	Name
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
OSBPL9	oxysterol binding protein-like 9
PDK2	pyruvate dehydrogenase kinase, isozyme 2
PDK3	pyruvate dehydrogenase kinase, isozyme 3
PDK4	pyruvate dehydrogenase kinase, isozyme 4
PKD1	polycystic kidney disease 1 (autosomal dominant)
PKD2	polycystic kidney disease 2 (autosomal dominant)
PPARD	peroxisome proliferator-activated receptor delta
PRKCA	protein kinase C, alpha
TP53	tumor protein p53