pdx1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description pancreatic and duodenal homeobox 1|The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3651)
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Genes

42 genes co-occuring with the biological term pdx1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACVR1C activin A receptor, type IC
AKT1 v-akt murine thymoma viral oncogene homolog 1
ATF2 activating transcription factor 2
ATF3 activating transcription factor 3
CDX2 caudal type homeobox 2
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
FABP1 fatty acid binding protein 1, liver
FGF4 fibroblast growth factor 4
FOXA2 forkhead box A2
FOXO1 forkhead box O1
GCG glucagon
GIP gastric inhibitory polypeptide
GSK3B glycogen synthase kinase 3 beta
IAPP islet amyloid polypeptide
IL1A interleukin 1, alpha
INHBB inhibin, beta B
INS insulin
ISL1 ISL LIM homeobox 1
KLF11 Kruppel-like factor 11
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
NES nestin
NEUROD1 neuronal differentiation 1
NEUROG3 neurogenin 3
NKX6-1 NK6 homeobox 1
NR5A2 nuclear receptor subfamily 5, group A, member 2
PASK PAS domain containing serine/threonine kinase
PAX6 paired box 6
PBX1 pre-B-cell leukemia homeobox 1
PDX1 pancreatic and duodenal homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PTCH1 patched 1
SHB Src homology 2 domain containing adaptor protein B
SHH sonic hedgehog
SREBF1 sterol regulatory element binding transcription factor 1
STK4 serine/threonine kinase 4
TFF1 trefoil factor 1
TFF2 trefoil factor 2
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPC6 transient receptor potential cation channel, subfamily C, member 6