pentetrazol-5508 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the pentetrazol-5508 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHI1 Abelson helper integration site 1
AHSP alpha hemoglobin stabilizing protein
ANGEL2 angel homolog 2 (Drosophila)
AOX1 aldehyde oxidase 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOE apolipoprotein E
ARG1 arginase 1
ASPH aspartate beta-hydroxylase
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BMP8B bone morphogenetic protein 8b
C11ORF63 chromosome 11 open reading frame 63
C14ORF1 chromosome 14 open reading frame 1
C22ORF24 chromosome 22 open reading frame 24
C22ORF46 chromosome 22 open reading frame 46
CCNK cyclin K
CDH10 cadherin 10, type 2 (T2-cadherin)
CEP164 centrosomal protein 164kDa
CLGN calmegin
COL14A1 collagen, type XIV, alpha 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DENND5B DENN/MADD domain containing 5B
DFNB31 deafness, autosomal recessive 31
DSC3 desmocollin 3
DTNA dystrobrevin, alpha
ENO3 enolase 3 (beta, muscle)
FHL1 four and a half LIM domains 1
FLJ11292
GAL galanin/GMAP prepropeptide
GMPR guanosine monophosphate reductase
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GREM2 gremlin 2, DAN family BMP antagonist
HBB hemoglobin, beta
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-G major histocompatibility complex, class I, G
HOXA2 homeobox A2
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFT38 intraflagellar transport 38
IL9R interleukin 9 receptor
KIAA1456 KIAA1456
KRTAP4-7 keratin associated protein 4-7
LAPTM5 lysosomal protein transmembrane 5
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MDM4 MDM4, p53 regulator
MKL1 megakaryoblastic leukemia (translocation) 1
MST1 macrophage stimulating 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTSS1 metastasis suppressor 1
MYT1 myelin transcription factor 1
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NOVA2 neuro-oncological ventral antigen 2
NPAS1 neuronal PAS domain protein 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRIP3 nuclear receptor interacting protein 3
NUP88 nucleoporin 88kDa
OSMR oncostatin M receptor
PCDHA6 protocadherin alpha 6
PDLIM7 PDZ and LIM domain 7 (enigma)
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAC4 placenta-specific 4
PLAT plasminogen activator, tissue
PLCE1 phospholipase C, epsilon 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHS1 pleckstrin homology domain containing, family S member 1
PLK4 polo-like kinase 4
POU4F2 POU class 4 homeobox 2
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RNF17 ring finger protein 17
RUFY3 RUN and FYVE domain containing 3
RUNDC3A RUN domain containing 3A
SDC3 syndecan 3
SIGLEC6 sialic acid binding Ig-like lectin 6
SKI SKI proto-oncogene
SLC35E2 solute carrier family 35, member E2
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SOS2 son of sevenless homolog 2 (Drosophila)
SOX21 SRY (sex determining region Y)-box 21
SP100 SP100 nuclear antigen
STK17A serine/threonine kinase 17a
TAPBP TAP binding protein (tapasin)
TBX10 T-box 10
TBX2 T-box 2
TCP11 t-complex 11, testis-specific
TCP11L1 t-complex 11, testis-specific-like 1
TDRD12 tudor domain containing 12
TPK1 thiamin pyrophosphokinase 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZFPL1 zinc finger protein-like 1
ZNF235 zinc finger protein 235
ZNF862 zinc finger protein 862
ZYX zyxin

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AFF4 AF4/FMR2 family, member 4
ALG12 ALG12, alpha-1,6-mannosyltransferase
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARMC7 armadillo repeat containing 7
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
BAHD1 bromo adjacent homology domain containing 1
BTBD2 BTB (POZ) domain containing 2
C16ORF45 chromosome 16 open reading frame 45
CAPN5 calpain 5
CBX4 chromobox homolog 4
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD83 CD83 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CLEC4E C-type lectin domain family 4, member E
CNR2 cannabinoid receptor 2 (macrophage)
COL9A2 collagen, type IX, alpha 2
CRELD1 cysteine-rich with EGF-like domains 1
DGKE diacylglycerol kinase, epsilon 64kDa
DHRS11 dehydrogenase/reductase (SDR family) member 11
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ELP3 elongator acetyltransferase complex subunit 3
ELSPBP1 epididymal sperm binding protein 1
FAM131A family with sequence similarity 131, member A
FBRS fibrosin
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCHO1 FCH domain only 1
FURIN furin (paired basic amino acid cleaving enzyme)
GNL1 guanine nucleotide binding protein-like 1
GPX2 glutathione peroxidase 2
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H3G histone cluster 1, H3g
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA2 heat shock 70kDa protein 2
IL15RA interleukin 15 receptor, alpha
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IRF6 interferon regulatory factor 6
ITPKB inositol-trisphosphate 3-kinase B
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KDM5C lysine (K)-specific demethylase 5C
KIAA0894 KIAA0894 protein
KRI1 KRI1 homolog (S. cerevisiae)
LAX1 lymphocyte transmembrane adaptor 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MBTPS2 membrane-bound transcription factor peptidase, site 2
MDK midkine (neurite growth-promoting factor 2)
MSI1 musashi RNA-binding protein 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NRGN neurogranin (protein kinase C substrate, RC3)
NT5DC3 5'-nucleotidase domain containing 3
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PKN1 protein kinase N1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLIN3 perilipin 3
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PRSS8 protease, serine, 8
PTK6 protein tyrosine kinase 6
PVRL3 poliovirus receptor-related 3
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3A RAB3A, member RAS oncogene family
RAB5B RAB5B, member RAS oncogene family
RASA2 RAS p21 protein activator 2
RFTN1 raftlin, lipid raft linker 1
RNF121 ring finger protein 121
RNF123 ring finger protein 123
RPAP2 RNA polymerase II associated protein 2
RPL13P5 ribosomal protein L13 pseudogene 5
SCAMP4 secretory carrier membrane protein 4
SCGB2A2 secretoglobin, family 2A, member 2
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SETD8 SET domain containing (lysine methyltransferase) 8
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIRT6 sirtuin 6
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMYD3 SET and MYND domain containing 3
THBS3 thrombospondin 3
TKFC triokinase/FMN cyclase
TMEM62 transmembrane protein 62
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TNNT1 troponin T type 1 (skeletal, slow)
TRAPPC6A trafficking protein particle complex 6A
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBE2O ubiquitin-conjugating enzyme E2O
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR62 WD repeat domain 62
WDR76 WD repeat domain 76