pentoxifylline-2290 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the pentoxifylline-2290 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
AIF1 allograft inflammatory factor 1
AIM1L absent in melanoma 1-like
AKAP1 A kinase (PRKA) anchor protein 1
APC adenomatous polyposis coli
ARMC4 armadillo repeat containing 4
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATAD5 ATPase family, AAA domain containing 5
BHMT2 betaine--homocysteine S-methyltransferase 2
BIRC7 baculoviral IAP repeat containing 7
C10ORF12 chromosome 10 open reading frame 12
C21ORF2 chromosome 21 open reading frame 2
C7ORF69 chromosome 7 open reading frame 69
CAV2 caveolin 2
CCL22 chemokine (C-C motif) ligand 22
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD47 CD47 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CNOT2 CCR4-NOT transcription complex, subunit 2
CREM cAMP responsive element modulator
CTTN cortactin
DAPK1 death-associated protein kinase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DPP4 dipeptidyl-peptidase 4
ELL elongation factor RNA polymerase II
ELOVL5 ELOVL fatty acid elongase 5
EPOR erythropoietin receptor
FASLG Fas ligand (TNF superfamily, member 6)
FGF5 fibroblast growth factor 5
FLRT2 fibronectin leucine rich transmembrane protein 2
FRMD4B FERM domain containing 4B
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2
GLT8D2 glycosyltransferase 8 domain containing 2
GPER1 G protein-coupled estrogen receptor 1
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR182 G protein-coupled receptor 182
GREB1L growth regulation by estrogen in breast cancer-like
GYPB glycophorin B (MNS blood group)
HCRP1 hepatocellular carcinoma-related HCRP1
HDAC11 histone deacetylase 11
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HMGN5 high mobility group nucleosome binding domain 5
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HYAL1 hyaluronoglucosaminidase 1
INO80B INO80 complex subunit B
IPW imprinted in Prader-Willi syndrome (non-protein coding)
LAMA4 laminin, alpha 4
LTBP4 latent transforming growth factor beta binding protein 4
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAB21L1 mab-21-like 1 (C. elegans)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MBNL2 muscleblind-like splicing regulator 2
MEG3 maternally expressed 3 (non-protein coding)
MZF1 myeloid zinc finger 1
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NOX1 NADPH oxidase 1
NPY6R neuropeptide Y receptor Y6 (pseudogene)
OR2W1 olfactory receptor, family 2, subfamily W, member 1
PALM paralemmin
PCDHGB5 protocadherin gamma subfamily B, 5
PDE4DIP phosphodiesterase 4D interacting protein
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDLIM3 PDZ and LIM domain 3
PLEK pleckstrin
PNPLA3 patatin-like phospholipase domain containing 3
POFUT1 protein O-fucosyltransferase 1
PRUNE2 prune homolog 2 (Drosophila)
PTHLH parathyroid hormone-like hormone
RERE arginine-glutamic acid dipeptide (RE) repeats
RGS14 regulator of G-protein signaling 14
RHBG Rh family, B glycoprotein (gene/pseudogene)
RIN3 Ras and Rab interactor 3
RUNX1 runt-related transcription factor 1
SCN11A sodium channel, voltage gated, type XI alpha subunit
SCN4A sodium channel, voltage gated, type IV alpha subunit
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SEC24D SEC24 family member D
SFRP4 secreted frizzled-related protein 4
SFTPB surfactant protein B
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC14A2 solute carrier family 14 (urea transporter), member 2
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SPG20 spastic paraplegia 20 (Troyer syndrome)
STAB1 stabilin 1
SULT4A1 sulfotransferase family 4A, member 1
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TEP1 telomerase-associated protein 1
TGM2 transglutaminase 2
TMEM206 transmembrane protein 206
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRPM2 transient receptor potential cation channel, subfamily M, member 2
VAV2 vav 2 guanine nucleotide exchange factor
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
XYLB xylulokinase homolog (H. influenzae)
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ALPK1 alpha-kinase 1
APOC1 apolipoprotein C-I
ARHGAP4 Rho GTPase activating protein 4
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BBC3 BCL2 binding component 3
BGLAP bone gamma-carboxyglutamate (gla) protein
C11ORF21 chromosome 11 open reading frame 21
C4ORF29 chromosome 4 open reading frame 29
C9ORF9 chromosome 9 open reading frame 9
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAMK4 calcium/calmodulin-dependent protein kinase IV
CAPG capping protein (actin filament), gelsolin-like
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX4 chromobox homolog 4
CCDC134 coiled-coil domain containing 134
CDHR2 cadherin-related family member 2
CIC capicua transcriptional repressor
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLIP4 CAP-GLY domain containing linker protein family, member 4
CLSTN2 calsyntenin 2
DUSP9 dual specificity phosphatase 9
DVL1 dishevelled segment polarity protein 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ELP6 elongator acetyltransferase complex subunit 6
EPB41L5 erythrocyte membrane protein band 4.1 like 5
FAM160B2 family with sequence similarity 160, member B2
FAM76A family with sequence similarity 76, member A
FBXL2 F-box and leucine-rich repeat protein 2
FBXO2 F-box protein 2
FFAR2 free fatty acid receptor 2
FGD1 FYVE, RhoGEF and PH domain containing 1
FMOD fibromodulin
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GAS2 growth arrest-specific 2
GEM GTP binding protein overexpressed in skeletal muscle
GLRA1 glycine receptor, alpha 1
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GUSBP3 glucuronidase, beta pseudogene 3
HOXA4 homeobox A4
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
INO80D INO80 complex subunit D
IREB2 iron-responsive element binding protein 2
KCTD17 potassium channel tetramerization domain containing 17
KDM8 lysine (K)-specific demethylase 8
KIF13A kinesin family member 13A
KIF13B kinesin family member 13B
KREMEN2 kringle containing transmembrane protein 2
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
LIME1 Lck interacting transmembrane adaptor 1
LINC01587 long intergenic non-protein coding RNA 1587
MALL mal, T-cell differentiation protein-like
MANBA mannosidase, beta A, lysosomal
MTCP1 mature T-cell proliferation 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOL10 nucleolar protein 10
NPIPB15 nuclear pore complex interacting protein family, member B15
NRSN2 neurensin 2
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PARG poly (ADP-ribose) glycohydrolase
PLA2G15 phospholipase A2, group XV
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLAC1 placenta-specific 1
PLD3 phospholipase D family, member 3
PLTP phospholipid transfer protein
PRDM16 PR domain containing 16
PTPRU protein tyrosine phosphatase, receptor type, U
RCAN3 RCAN family member 3
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFPL1S RFPL1 antisense RNA 1
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPL23AP32 ribosomal protein L23a pseudogene 32
SAYSD1 SAYSVFN motif domain containing 1
SCD5 stearoyl-CoA desaturase 5
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SPON2 spondin 2, extracellular matrix protein
SRD5A3 steroid 5 alpha-reductase 3
STIM1 stromal interaction molecule 1
TBC1D2 TBC1 domain family, member 2
TBKBP1 TBK1 binding protein 1
TBX19 T-box 19
THBS3 thrombospondin 3
THRAP3 thyroid hormone receptor associated protein 3
TLN1 talin 1
TMEM8B transmembrane protein 8B
TPK1 thiamin pyrophosphokinase 1
TRDMT1 tRNA aspartic acid methyltransferase 1
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
WDR91 WD repeat domain 91
ZNF76 zinc finger protein 76