pentoxyverine-2623 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the pentoxyverine-2623 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM23 ADAM metallopeptidase domain 23
AMPH amphiphysin
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
ARPIN actin-related protein 2/3 complex inhibitor
BIN1 bridging integrator 1
C14ORF79 chromosome 14 open reading frame 79
CA4 carbonic anhydrase IV
CARD14 caspase recruitment domain family, member 14
CCR1 chemokine (C-C motif) receptor 1
CD2 CD2 molecule
CD28 CD28 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CLSTN2 calsyntenin 2
CNPPD1 cyclin Pas1/PHO80 domain containing 1
COL1A2 collagen, type I, alpha 2
CRIP1 cysteine-rich protein 1 (intestinal)
CSF1 colony stimulating factor 1 (macrophage)
CTIF CBP80/20-dependent translation initiation factor
CTSZ cathepsin Z
DFNA5 deafness, autosomal dominant 5
DOK2 docking protein 2, 56kDa
ELAVL4 ELAV like neuron-specific RNA binding protein 4
ELF5 E74-like factor 5 (ets domain transcription factor)
FADS2 fatty acid desaturase 2
FCAR Fc fragment of IgA receptor
FLJ21369 uncharacterized protein FLJ21369
FSHB follicle stimulating hormone, beta polypeptide
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GAS7 growth arrest-specific 7
GBP1 guanylate binding protein 1, interferon-inducible
GLS glutaminase
GPR153 G protein-coupled receptor 153
GPR50 G protein-coupled receptor 50
HIST1H3I histone cluster 1, H3i
HLA-DOA major histocompatibility complex, class II, DO alpha
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IGFBP5 insulin-like growth factor binding protein 5
IL1A interleukin 1, alpha
ITPKA inositol-trisphosphate 3-kinase A
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCTD12 potassium channel tetramerization domain containing 12
KDM4C lysine (K)-specific demethylase 4C
KIAA1456 KIAA1456
LAMA4 laminin, alpha 4
LAT2 linker for activation of T cells family, member 2
LGALS4 lectin, galactoside-binding, soluble, 4
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MARK4 MAP/microtubule affinity-regulating kinase 4
MASP2 mannan-binding lectin serine peptidase 2
MCC mutated in colorectal cancers
MED16 mediator complex subunit 16
MFAP3L microfibrillar-associated protein 3-like
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYH14 myosin, heavy chain 14, non-muscle
MYO1B myosin IB
NMT1 N-myristoyltransferase 1
NOX1 NADPH oxidase 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRG2 neuregulin 2
PAX2 paired box 2
PDAP1 PDGFA associated protein 1
PDE4DIP phosphodiesterase 4D interacting protein
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PSD4 pleckstrin and Sec7 domain containing 4
PTK7 protein tyrosine kinase 7 (inactive)
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RANBP10 RAN binding protein 10
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RPLP2 ribosomal protein, large, P2
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SNTA1 syntrophin, alpha 1
SORBS3 sorbin and SH3 domain containing 3
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SYNE1 spectrin repeat containing, nuclear envelope 1
TCF3 transcription factor 3
TGM2 transglutaminase 2
TMC6 transmembrane channel-like 6
TRAF3IP3 TRAF3 interacting protein 3
TTLL3 tubulin tyrosine ligase-like family member 3
VNN2 vanin 2
WNT1 wingless-type MMTV integration site family, member 1
ZC3H13 zinc finger CCCH-type containing 13
ZNF778 zinc finger protein 778

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ACSF2 acyl-CoA synthetase family member 2
ADGRE5 adhesion G protein-coupled receptor E5
AFF4 AF4/FMR2 family, member 4
AKTIP AKT interacting protein
ATAD3A ATPase family, AAA domain containing 3A
ATP7B ATPase, Cu++ transporting, beta polypeptide
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BCOR BCL6 corepressor
C22ORF46 chromosome 22 open reading frame 46
C5AR2 complement component 5a receptor 2
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC25 coiled-coil domain containing 25
CD79B CD79b molecule, immunoglobulin-associated beta
CEP97 centrosomal protein 97kDa
CHKB choline kinase beta
CLCF1 cardiotrophin-like cytokine factor 1
CLCN2 chloride channel, voltage-sensitive 2
CLCN5 chloride channel, voltage-sensitive 5
CNGB3 cyclic nucleotide gated channel beta 3
CRELD1 cysteine-rich with EGF-like domains 1
DOCK1 dedicator of cytokinesis 1
EFNA3 ephrin-A3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN2 endoplasmic reticulum to nucleus signaling 2
ETAA1 Ewing tumor-associated antigen 1
FAM188A family with sequence similarity 188, member A
FBXL15 F-box and leucine-rich repeat protein 15
FBXO46 F-box protein 46
FCHSD2 FCH and double SH3 domains 2
FKBP14 FK506 binding protein 14, 22 kDa
FLRT3 fibronectin leucine rich transmembrane protein 3
GEMIN8 gem (nuclear organelle) associated protein 8
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST2H2AA3 histone cluster 2, H2aa3
HOXC10 homeobox C10
INO80D INO80 complex subunit D
KDM5C lysine (K)-specific demethylase 5C
LHX1 LIM homeobox 1
LIG4 ligase IV, DNA, ATP-dependent
LIN7A lin-7 homolog A (C. elegans)
LOC390998 ribosomal protein L10 pseudogene
LY6D lymphocyte antigen 6 complex, locus D
LYPD1 LY6/PLAUR domain containing 1
MAGEF1 melanoma antigen family F1
MAMLD1 mastermind-like domain containing 1
MORC3 MORC family CW-type zinc finger 3
MYLIP myosin regulatory light chain interacting protein
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NKX3-2 NK3 homeobox 2
NLK nemo-like kinase
NME6 NME/NM23 nucleoside diphosphate kinase 6
NPM3 nucleophosmin/nucleoplasmin 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PDZRN3 PDZ domain containing ring finger 3
PHEX phosphate regulating endopeptidase homolog, X-linked
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PMCH pro-melanin-concentrating hormone
PODXL2 podocalyxin-like 2
POTEKP POTE ankyrin domain family, member K, pseudogene
PTDSS2 phosphatidylserine synthase 2
PTTG3P pituitary tumor-transforming 3, pseudogene
REEP4 receptor accessory protein 4
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RNF121 ring finger protein 121
RNF38 ring finger protein 38
S100A4 S100 calcium binding protein A4
SCN1B sodium channel, voltage gated, type I beta subunit
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SGK1 serum/glucocorticoid regulated kinase 1
SLC12A9 solute carrier family 12, member 9
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A40 solute carrier family 25, member 40
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC46A3 solute carrier family 46, member 3
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINK5 serine peptidase inhibitor, Kazal type 5
STBD1 starch binding domain 1
THBS3 thrombospondin 3
TMPRSS3 transmembrane protease, serine 3
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TTLL1 tubulin tyrosine ligase-like family member 1
UBQLN4 ubiquilin 4
WDR4 WD repeat domain 4
XYLT2 xylosyltransferase II
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF141 zinc finger protein 141
ZNF23 zinc finger protein 23
ZNF329 zinc finger protein 329
ZNF34 zinc finger protein 34
ZNF552 zinc finger protein 552
ZNF571 zinc finger protein 571
ZNF75D zinc finger protein 75D