pepstatin-3264 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the pepstatin-3264 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
ADK adenosine kinase
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APAF1 apoptotic peptidase activating factor 1
ARMC8 armadillo repeat containing 8
ASPH aspartate beta-hydroxylase
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
BAIAP3 BAI1-associated protein 3
C10ORF95 chromosome 10 open reading frame 95
C11ORF30 chromosome 11 open reading frame 30
C17ORF59 chromosome 17 open reading frame 59
C7ORF43 chromosome 7 open reading frame 43
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CDC42 cell division cycle 42
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CTBS chitobiase, di-N-acetyl-
DMTN dematin actin binding protein
DPY19L1P1 DPY19L1 pseudogene 1
DTNA dystrobrevin, alpha
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
F12 coagulation factor XII (Hageman factor)
FLII flightless I homolog (Drosophila)
FN1 fibronectin 1
FPGS folylpolyglutamate synthase
FSCN1 fascin actin-bundling protein 1
GSK3A glycogen synthase kinase 3 alpha
HAP1 huntingtin-associated protein 1
HCFC1 host cell factor C1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H4D histone cluster 1, H4d
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGFBP7 insulin-like growth factor binding protein 7
IL5RA interleukin 5 receptor, alpha
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KITLG KIT ligand
LEPROT leptin receptor overlapping transcript
LIMCH1 LIM and calponin homology domains 1
LMF2 lipase maturation factor 2
LRP2 low density lipoprotein receptor-related protein 2
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK7 mitogen-activated protein kinase 7
MARS methionyl-tRNA synthetase
MMRN2 multimerin 2
MSMB microseminoprotein, beta-
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MVB12B multivesicular body subunit 12B
MXD4 MAX dimerization protein 4
NABP2 nucleic acid binding protein 2
NFRKB nuclear factor related to kappaB binding protein
NNT nicotinamide nucleotide transhydrogenase
NUMA1 nuclear mitotic apparatus protein 1
NYNRIN NYN domain and retroviral integrase containing
OSGIN2 oxidative stress induced growth inhibitor family member 2
PAIP2B poly(A) binding protein interacting protein 2B
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE4C phosphodiesterase 4C, cAMP-specific
PDE8B phosphodiesterase 8B
PHF3 PHD finger protein 3
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLK3 polo-like kinase 3
PLK4 polo-like kinase 4
POFUT1 protein O-fucosyltransferase 1
POMT2 protein-O-mannosyltransferase 2
PPARA peroxisome proliferator-activated receptor alpha
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RIMS3 regulating synaptic membrane exocytosis 3
RUSC2 RUN and SH3 domain containing 2
S100A8 S100 calcium binding protein A8
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEC63 SEC63 homolog (S. cerevisiae)
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SMC5 structural maintenance of chromosomes 5
SOX30 SRY (sex determining region Y)-box 30
SRPR signal recognition particle receptor (docking protein)
SRRM2 serine/arginine repetitive matrix 2
SUGP1 SURP and G patch domain containing 1
SYMPK symplekin
TADA2A transcriptional adaptor 2A
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TGFB2 transforming growth factor, beta 2
TMEM120B transmembrane protein 120B
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN9 tetraspanin 9
TUBA3C tubulin, alpha 3c
USP22 ubiquitin specific peptidase 22
USP24 ubiquitin specific peptidase 24
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
WASF1 WAS protein family, member 1
WDR1 WD repeat domain 1
ZER1 zyg-11 related, cell cycle regulator
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACTL8 actin-like 8
ADAP2 ArfGAP with dual PH domains 2
ADGRG2 adhesion G protein-coupled receptor G2
AFF4 AF4/FMR2 family, member 4
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ALPK1 alpha-kinase 1
AMT aminomethyltransferase
AUTS2 autism susceptibility candidate 2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BATF basic leucine zipper transcription factor, ATF-like
C11ORF80 chromosome 11 open reading frame 80
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CCDC85C coiled-coil domain containing 85C
CDK18 cyclin-dependent kinase 18
CERS4 ceramide synthase 4
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHML choroideremia-like (Rab escort protein 2)
CLCN6 chloride channel, voltage-sensitive 6
CLSTN2 calsyntenin 2
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CRYBB2P1 crystallin, beta B2 pseudogene 1
CSF1R colony stimulating factor 1 receptor
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
EFNA3 ephrin-A3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM131A family with sequence similarity 131, member A
GADD45G growth arrest and DNA-damage-inducible, gamma
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR143 G protein-coupled receptor 143
GREB1L growth regulation by estrogen in breast cancer-like
GSTM2 glutathione S-transferase mu 2 (muscle)
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HDAC11 histone deacetylase 11
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BO histone cluster 1, H2bo
HIST1H4F histone cluster 1, H4f
HIST2H2AA3 histone cluster 2, H2aa3
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL17RA interleukin 17 receptor A
IQSEC2 IQ motif and Sec7 domain 2
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL36 kelch-like family member 36
KLK5 kallikrein-related peptidase 5
KPNA5 karyopherin alpha 5 (importin alpha 6)
LHX1 LIM homeobox 1
LHX6 LIM homeobox 6
NPTX1 neuronal pentraxin I
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OSGIN1 oxidative stress induced growth inhibitor 1
PACS1 phosphofurin acidic cluster sorting protein 1
PCDHB13 protocadherin beta 13
PDIA3 protein disulfide isomerase family A, member 3
PGR progesterone receptor
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRR4 proline rich 4 (lacrimal)
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RLN1 relaxin 1
RNF122 ring finger protein 122
RNF123 ring finger protein 123
SCD5 stearoyl-CoA desaturase 5
SIGLEC15 sialic acid binding Ig-like lectin 15
SIX1 SIX homeobox 1
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLMO1 slowmo homolog 1 (Drosophila)
SNAI2 snail family zinc finger 2
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TJAP1 tight junction associated protein 1 (peripheral)
TMEM209 transmembrane protein 209
TMPRSS4 transmembrane protease, serine 4
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TOR4A torsin family 4, member A
TRIM21 tripartite motif containing 21
TRIM66 tripartite motif containing 66
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USB1 U6 snRNA biogenesis 1
VEGFB vascular endothelial growth factor B
WDR62 WD repeat domain 62
WFDC2 WAP four-disulfide core domain 2
ZBTB22 zinc finger and BTB domain containing 22
ZBTB44 zinc finger and BTB domain containing 44
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF532 zinc finger protein 532
ZNF652 zinc finger protein 652
ZNF747 zinc finger protein 747