pepstatin-4206 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the pepstatin-4206 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AADAC arylacetamide deacetylase
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ACOT11 acyl-CoA thioesterase 11
ACVR1B activin A receptor, type IB
ADAM22 ADAM metallopeptidase domain 22
AGFG2 ArfGAP with FG repeats 2
AIM1L absent in melanoma 1-like
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATG10 autophagy related 10
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATXN7L1 ataxin 7-like 1
BATF basic leucine zipper transcription factor, ATF-like
C11ORF63 chromosome 11 open reading frame 63
C17ORF53 chromosome 17 open reading frame 53
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC7 coiled-coil domain containing 7
CCNT2 cyclin T2
CD34 CD34 molecule
CDC42 cell division cycle 42
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNTN1 contactin 1
COL21A1 collagen, type XXI, alpha 1
CSPG4 chondroitin sulfate proteoglycan 4
CTC1 CTS telomere maintenance complex component 1
CXCL5 chemokine (C-X-C motif) ligand 5
CXCR4 chemokine (C-X-C motif) receptor 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DOCK6 dedicator of cytokinesis 6
DTNA dystrobrevin, alpha
DYM dymeclin
EDIL3 EGF-like repeats and discoidin I-like domains 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FOXN2 forkhead box N2
FRMD4A FERM domain containing 4A
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GPR17 G protein-coupled receptor 17
GPR21 G protein-coupled receptor 21
HIPK3 homeodomain interacting protein kinase 3
HIST1H2AL histone cluster 1, H2al
HIST1H2BM histone cluster 1, H2bm
HSF2BP heat shock transcription factor 2 binding protein
IFITM1 interferon induced transmembrane protein 1
IGFBP1 insulin-like growth factor binding protein 1
INO80D INO80 complex subunit D
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
LAMA2 laminin, alpha 2
MAGEA5 melanoma antigen family A5
MEF2D myocyte enhancer factor 2D
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MKL1 megakaryoblastic leukemia (translocation) 1
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NF1 neurofibromin 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPC1 Niemann-Pick disease, type C1
NRP2 neuropilin 2
OXCT2 3-oxoacid CoA transferase 2
PALMD palmdelphin
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PNPLA3 patatin-like phospholipase domain containing 3
PPARD peroxisome proliferator-activated receptor delta
PQLC2 PQ loop repeat containing 2
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
RAB36 RAB36, member RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RIMS3 regulating synaptic membrane exocytosis 3
RNGTT RNA guanylyltransferase and 5'-phosphatase
RPL35A ribosomal protein L35a
SBNO1 strawberry notch homolog 1 (Drosophila)
SCAMP1 secretory carrier membrane protein 1
SCARB1 scavenger receptor class B, member 1
SH2D3A SH2 domain containing 3A
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOS2 son of sevenless homolog 2 (Drosophila)
SPTBN4 spectrin, beta, non-erythrocytic 4
SUGP1 SURP and G patch domain containing 1
SYNJ1 synaptojanin 1
TRIM29 tripartite motif containing 29
TUBA4B tubulin, alpha 4b
WSB1 WD repeat and SOCS box containing 1
ZMYM5 zinc finger, MYM-type 5
ZNF280B zinc finger protein 280B
ZNF500 zinc finger protein 500
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ACE angiotensin I converting enzyme
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARRB2 arrestin, beta 2
BFSP1 beaded filament structural protein 1, filensin
BMP15 bone morphogenetic protein 15
BOLA1 bolA family member 1
C14ORF105 chromosome 14 open reading frame 105
C16ORF62 chromosome 16 open reading frame 62
C22ORF46 chromosome 22 open reading frame 46
C8A complement component 8, alpha polypeptide
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASS4 Cas scaffolding protein family member 4
CD68 CD68 molecule
CLDN1 claudin 1
CLTCL1 clathrin, heavy chain-like 1
CNN1 calponin 1, basic, smooth muscle
CRYGC crystallin, gamma C
DDN dendrin
DSPP dentin sialophosphoprotein
EBF2 early B-cell factor 2
ERN2 endoplasmic reticulum to nucleus signaling 2
ETV4 ets variant 4
FLJ21369 uncharacterized protein FLJ21369
FLT4 fms-related tyrosine kinase 4
FRMPD1 FERM and PDZ domain containing 1
FRS3 fibroblast growth factor receptor substrate 3
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GRM4 glutamate receptor, metabotropic 4
HIST1H2AI histone cluster 1, H2ai
HIST1H2BN histone cluster 1, H2bn
HIST1H3F histone cluster 1, H3f
HOXA4 homeobox A4
HOXA6 homeobox A6
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
ICOS inducible T-cell co-stimulator
IFT140 intraflagellar transport 140
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
ITGB7 integrin, beta 7
KANSL3 KAT8 regulatory NSL complex subunit 3
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KDM5C lysine (K)-specific demethylase 5C
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIAA1456 KIAA1456
KLF13 Kruppel-like factor 13
KLHL36 kelch-like family member 36
KRT20 keratin 20, type I
LOC157562 uncharacterized LOC157562
LPAR3 lysophosphatidic acid receptor 3
LY6D lymphocyte antigen 6 complex, locus D
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MFGE8 milk fat globule-EGF factor 8 protein
MGP matrix Gla protein
MRAS muscle RAS oncogene homolog
MTCP1 mature T-cell proliferation 1
MYH15 myosin, heavy chain 15
MYO15A myosin XVA
NRGN neurogranin (protein kinase C substrate, RC3)
NSUN6 NOP2/Sun domain family, member 6
NT5M 5',3'-nucleotidase, mitochondrial
ODF2 outer dense fiber of sperm tails 2
OLFML2A olfactomedin-like 2A
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PADI1 peptidyl arginine deiminase, type I
PCDH12 protocadherin 12
PLBD1 phospholipase B domain containing 1
PRB3 proline-rich protein BstNI subfamily 3
PRSS53 protease, serine, 53
RAB11B RAB11B, member RAS oncogene family
RAPSN receptor-associated protein of the synapse
RNF126P1 ring finger protein 126 pseudogene 1
RNF39 ring finger protein 39
SCG2 secretogranin II
SERGEF secretion regulating guanine nucleotide exchange factor
SIRT6 sirtuin 6
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SMA4 glucuronidase, beta pseudogene
SOX21 SRY (sex determining region Y)-box 21
TAGLN3 transgelin 3
TESPA1 thymocyte expressed, positive selection associated 1
TLN1 talin 1
TMEM212 transmembrane protein 212
TMPRSS4 transmembrane protease, serine 4
TPRA1 transmembrane protein, adipocyte asscociated 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTLL1 tubulin tyrosine ligase-like family member 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WNT10B wingless-type MMTV integration site family, member 10B
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF222 zinc finger protein 222
ZNF324 zinc finger protein 324
ZNF358 zinc finger protein 358
ZNF862 zinc finger protein 862