pergolide-2403 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the pergolide-2403 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADD3 adducin 3 (gamma)
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ARL4C ADP-ribosylation factor-like 4C
AURKA aurora kinase A
AXL AXL receptor tyrosine kinase
BBS4 Bardet-Biedl syndrome 4
BCL3 B-cell CLL/lymphoma 3
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CCL20 chemokine (C-C motif) ligand 20
CCL22 chemokine (C-C motif) ligand 22
CCNG2 cyclin G2
CD38 CD38 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD86 CD86 molecule
CDC25C cell division cycle 25C
CDHR2 cadherin-related family member 2
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFLAR CASP8 and FADD-like apoptosis regulator
CHN2 chimerin 2
CREM cAMP responsive element modulator
DENND5B DENN/MADD domain containing 5B
DNAH17 dynein, axonemal, heavy chain 17
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
DOCK10 dedicator of cytokinesis 10
DOCK4 dedicator of cytokinesis 4
DUSP4 dual specificity phosphatase 4
EMP1 epithelial membrane protein 1
FAM13A family with sequence similarity 13, member A
FAM214B family with sequence similarity 214, member B
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXO1 forkhead box O1
FTH1 ferritin, heavy polypeptide 1
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS7 growth arrest-specific 7
GBP2 guanylate binding protein 2, interferon-inducible
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNLY granulysin
GPR183 G protein-coupled receptor 183
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BH histone cluster 1, H2bh
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGB3 high mobility group box 3
HPSE heparanase
IL10RA interleukin 10 receptor, alpha
ISG20 interferon stimulated exonuclease gene 20kDa
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KIF1C kinesin family member 1C
KYNU kynureninase
LPAR6 lysophosphatidic acid receptor 6
MANBA mannosidase, beta A, lysosomal
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MX2 MX dynamin-like GTPase 2
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NOD2 nucleotide-binding oligomerization domain containing 2
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM2 PDZ and LIM domain 2 (mystique)
PECAM1 platelet/endothelial cell adhesion molecule 1
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLSCR1 phospholipid scramblase 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRDM1 PR domain containing 1, with ZNF domain
RASAL1 RAS protein activator like 1 (GAP1 like)
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLA Src-like-adaptor
SMOX spermine oxidase
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SS18 synovial sarcoma translocation, chromosome 18
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TGM5 transglutaminase 5
THBS1 thrombospondin 1
THEMIS2 thymocyte selection associated family member 2
TIMP1 TIMP metallopeptidase inhibitor 1
TRAF3IP2 TRAF3 interacting protein 2
TREM1 triggering receptor expressed on myeloid cells 1
ULK1 unc-51 like autophagy activating kinase 1
VWA5A von Willebrand factor A domain containing 5A
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
ADGRA3 adhesion G protein-coupled receptor A3
ADRB2 adrenoceptor beta 2, surface
ATAD3A ATPase family, AAA domain containing 3A
BAHCC1 BAH domain and coiled-coil containing 1
C12ORF29 chromosome 12 open reading frame 29
C17ORF70 chromosome 17 open reading frame 70
CCDC86 coiled-coil domain containing 86
CCNA1 cyclin A1
CHST10 carbohydrate sulfotransferase 10
CTPS1 CTP synthase 1
CTSG cathepsin G
DDN dendrin
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEPTOR DEP domain containing MTOR-interacting protein
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ERN2 endoplasmic reticulum to nucleus signaling 2
EXOSC5 exosome component 5
FKBP4 FK506 binding protein 4, 59kDa
FLT3 fms-related tyrosine kinase 3
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HSPA4L heat shock 70kDa protein 4-like
IDI1 isopentenyl-diphosphate delta isomerase 1
IFRD2 interferon-related developmental regulator 2
IRF8 interferon regulatory factor 8
ISOC2 isochorismatase domain containing 2
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KIAA0020 KIAA0020
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LRRK1 leucine-rich repeat kinase 1
MAK16 MAK16 homolog (S. cerevisiae)
MED22 mediator complex subunit 22
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT10 N-acetyltransferase 10 (GCN5-related)
NCS1 neuronal calcium sensor 1
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae)
NOL6 nucleolar protein 6 (RNA-associated)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
PA2G4 proliferation-associated 2G4, 38kDa
PCOLCE2 procollagen C-endopeptidase enhancer 2
PFAS phosphoribosylformylglycinamidine synthase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
POLH polymerase (DNA directed), eta
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPAN peter pan homolog (Drosophila)
PRDM13 PR domain containing 13
PRTN3 proteinase 3
PSAT1 phosphoserine aminotransferase 1
PTRH2 peptidyl-tRNA hydrolase 2
PUS1 pseudouridylate synthase 1
PUS7 pseudouridylate synthase 7 (putative)
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
QTRT1 queuine tRNA-ribosyltransferase 1
RNH1 ribonuclease/angiogenin inhibitor 1
RPIA ribose 5-phosphate isomerase A
RPP40 ribonuclease P/MRP 40kDa subunit
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RSAD1 radical S-adenosyl methionine domain containing 1
RUVBL1 RuvB-like AAA ATPase 1
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SIAH2 siah E3 ubiquitin protein ligase 2
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SMYD5 SMYD family member 5
SQLE squalene epoxidase
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TERT telomerase reverse transcriptase
TFB2M transcription factor B2, mitochondrial
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TTLL12 tubulin tyrosine ligase-like family member 12
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
WDR12 WD repeat domain 12
WDR3 WD repeat domain 3
WDR43 WD repeat domain 43
WT1 Wilms tumor 1
XBP1 X-box binding protein 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF37BP zinc finger protein 37B, pseudogene
ZNF747 zinc finger protein 747