pericentric heterochromatin Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3. (Gene Ontology, GO_0005721)
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Genes

108 proteins co-occuring with the pericentric heterochromatin cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CENPB centromere protein B, 80kDa 1.54574
H3F3A H3 histone, family 3A 1.08984
H3F3B H3 histone, family 3B (H3.3B) 1.08984
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 1.07258
ACTR6 ARP6 actin-related protein 6 homolog (yeast) 1.06954
CBX5 chromobox homolog 5 1.06701
ZWINT ZW10 interacting kinetochore protein 0.90646
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.849746
HIST1H4C histone cluster 1, H4c 0.845155
HIST1H4A histone cluster 1, H4a 0.845155
HIST1H4E histone cluster 1, H4e 0.845155
HIST1H4D histone cluster 1, H4d 0.845155
HIST1H4K histone cluster 1, H4k 0.845155
HIST1H4I histone cluster 1, H4i 0.845155
HIST1H4H histone cluster 1, H4h 0.845155
HIST1H4B histone cluster 1, H4b 0.845155
HIST2H4B histone cluster 2, H4b 0.845155
HIST1H4J histone cluster 1, H4j 0.845155
HIST1H4F histone cluster 1, H4f 0.844696
HIST4H4 histone cluster 4, H4 0.844696
HIST1H4L histone cluster 1, H4l 0.844696
HIST2H4A histone cluster 2, H4a 0.844696
CBX3 chromobox homolog 3 0.843318
DICER1 dicer 1, ribonuclease type III 0.781869
HMGB3 high mobility group box 3 0.778669
CENPC centromere protein C 0.755891
ZNF33A zinc finger protein 33A 0.706598
ZFP57 ZFP57 zinc finger protein 0.699103
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.658619
IL5RA interleukin 5 receptor, alpha 0.602331
WDR83 WD repeat domain 83 0.577581
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.567585
MMP15 matrix metallopeptidase 15 (membrane-inserted) 0.564677
APITD1 apoptosis-inducing, TAF9-like domain 1 0.554318
ECEL1 endothelin converting enzyme-like 1 0.534951
CHRM2 cholinergic receptor, muscarinic 2 0.532078
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.518981
H1FNT H1 histone family, member N, testis-specific 0.507977
CENPA centromere protein A 0.489731
ONECUT1 one cut homeobox 1 0.483273
MBD1 methyl-CpG binding domain protein 1 0.454418
RPL15 ribosomal protein L15 0.444085
LRWD1 leucine-rich repeats and WD repeat domain containing 1 0.435775
NSL1 NSL1, MIS12 kinetochore complex component 0.433012
NPM2 nucleophosmin/nucleoplasmin 2 0.431829
RBMY1A1 RNA binding motif protein, Y-linked, family 1, member A1 0.427497
SUMO1 small ubiquitin-like modifier 1 0.423567
AGO2 argonaute RISC catalytic component 2 0.412601
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.409869
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.399751
SIM2 single-minded family bHLH transcription factor 2 0.397811
RNF20 ring finger protein 20, E3 ubiquitin protein ligase 0.383895
MIS12 MIS12 kinetochore complex component 0.377354
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.371982
BRDT bromodomain, testis-specific 0.368153
HIST1H1T histone cluster 1, H1t 0.345314
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.333602
TOM1 target of myb1 (chicken) 0.332848
CCNA1 cyclin A1 0.321575
SOX1 SRY (sex determining region Y)-box 1 0.303283
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 0.302912
SMC1A structural maintenance of chromosomes 1A 0.298455
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.291417
DCLK3 doublecortin-like kinase 3 0.289199
CENPE centromere protein E, 312kDa 0.284401
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.279245
DNAH14 dynein, axonemal, heavy chain 14 0.274835
DNAH12 dynein, axonemal, heavy chain 12 0.274835
PPAT phosphoribosyl pyrophosphate amidotransferase 0.272633
TRIM28 tripartite motif containing 28 0.263485
DSE dermatan sulfate epimerase 0.258381
AURKB aurora kinase B 0.25547
DNAH5 dynein, axonemal, heavy chain 5 0.249664
TOP2A topoisomerase (DNA) II alpha 170kDa 0.248578
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.243879
CENPH centromere protein H 0.239916
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.218563
TRIM24 tripartite motif containing 24 0.215761
MECP2 methyl CpG binding protein 2 0.210894
PHGDH phosphoglycerate dehydrogenase 0.210894
SNRPN small nuclear ribonucleoprotein polypeptide N 0.209169
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.20574
HAT1 histone acetyltransferase 1 0.20574
DNAH9 dynein, axonemal, heavy chain 9 0.196999
H2AFY H2A histone family, member Y 0.193394
CHD1 chromodomain helicase DNA binding protein 1 0.173003
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.170888
EIF3A eukaryotic translation initiation factor 3, subunit A 0.170888
CASC5 cancer susceptibility candidate 5 0.170371
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.168598
BIN1 bridging integrator 1 0.16477
NBPF10 neuroblastoma breakpoint family, member 10 0.161905
HIST2H2AC histone cluster 2, H2ac 0.161484
HIST2H2AA3 histone cluster 2, H2aa3 0.161275
HIST2H2AA4 histone cluster 2, H2aa4 0.161275
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.15776
STC1 stanniocalcin 1 0.156688
BAGE2 B melanoma antigen family, member 2 0.156342
PORCN porcupine homolog (Drosophila) 0.140746
COPZ1 coatomer protein complex, subunit zeta 1 0.14069
GFER growth factor, augmenter of liver regeneration 0.140302
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.138307
AR androgen receptor 0.13804
ACO2 aconitase 2, mitochondrial 0.136368
M6PR mannose-6-phosphate receptor (cation dependent) 0.136338
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.135885
DCTN1 dynactin 1 0.134054
TUBA1A tubulin, alpha 1a 0.129405