perphenazine-2040 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the perphenazine-2040 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ACSL6 acyl-CoA synthetase long-chain family member 6
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANKRD12 ankyrin repeat domain 12
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASMTL acetylserotonin O-methyltransferase-like
ATM ATM serine/threonine kinase
BAX BCL2-associated X protein
BCL7A B-cell CLL/lymphoma 7A
BLZF1 basic leucine zipper nuclear factor 1
CCDC15 coiled-coil domain containing 15
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CEP70 centrosomal protein 70kDa
CLDN15 claudin 15
CLTCL1 clathrin, heavy chain-like 1
COG5 component of oligomeric golgi complex 5
CRY1 cryptochrome circadian clock 1
CTH cystathionine gamma-lyase
CTSS cathepsin S
CYLD cylindromatosis (turban tumor syndrome)
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DERL1 derlin 1
ELMO2 engulfment and cell motility 2
F11R F11 receptor
FGFBP1 fibroblast growth factor binding protein 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GCAT glycine C-acetyltransferase
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPR137 G protein-coupled receptor 137
GPRC5D G protein-coupled receptor, class C, group 5, member D
GRK5 G protein-coupled receptor kinase 5
HIRA histone cell cycle regulator
HK2 hexokinase 2
HLA-DOA major histocompatibility complex, class II, DO alpha
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFIH1 interferon induced with helicase C domain 1
ITSN1 intersectin 1 (SH3 domain protein)
KIFC1 kinesin family member C1
KLF6 Kruppel-like factor 6
KLHL7 kelch-like family member 7
KYNU kynureninase
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
MAGOH2P mago-nashi homolog 2, pseudogene
MCL1 myeloid cell leukemia 1
MOB3B MOB kinase activator 3B
N4BP2L2 NEDD4 binding protein 2-like 2
NDRG2 NDRG family member 2
NPM3 nucleophosmin/nucleoplasmin 3
NRIP1 nuclear receptor interacting protein 1
NRSN2 neurensin 2
OCRL oculocerebrorenal syndrome of Lowe
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCNXL4 pecanex-like 4 (Drosophila)
PDPK1 3-phosphoinositide dependent protein kinase 1
PFDN4 prefoldin subunit 4
PGM3 phosphoglucomutase 3
PICALM phosphatidylinositol binding clathrin assembly protein
PIDD1 p53-induced death domain protein 1
PILRB paired immunoglobin-like type 2 receptor beta
PRKCE protein kinase C, epsilon
RAD23B RAD23 homolog B (S. cerevisiae)
RBMS1 RNA binding motif, single stranded interacting protein 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RNF146 ring finger protein 146
RNF19B ring finger protein 19B
RUNDC3A RUN domain containing 3A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLMO2 slowmo homolog 2 (Drosophila)
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SPDEF SAM pointed domain containing ETS transcription factor
SPN sialophorin
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SPTSSA serine palmitoyltransferase, small subunit A
SSBP2 single-stranded DNA binding protein 2
STK16 serine/threonine kinase 16
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TES testin LIM domain protein
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM135 transmembrane protein 135
TPST1 tyrosylprotein sulfotransferase 1
TRABD TraB domain containing
TRAPPC11 trafficking protein particle complex 11
TRIM5 tripartite motif containing 5
TSC22D3 TSC22 domain family, member 3
UBE4B ubiquitination factor E4B
UBQLN4 ubiquilin 4
UCN urocortin
UTRN utrophin
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZC2HC1A zinc finger, C2HC-type containing 1A
ZNF227 zinc finger protein 227
ZNF426 zinc finger protein 426
ZNF443 zinc finger protein 443
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
ALPK1 alpha-kinase 1
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
APOO apolipoprotein O
ASAP1-IT1 ASAP1 intronic transcript 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKAIP1 aurora kinase A interacting protein 1
AXIN1 axin 1
BCORL1 BCL6 corepressor-like 1
C2ORF44 chromosome 2 open reading frame 44
C6ORF47 chromosome 6 open reading frame 47
CCDC130 coiled-coil domain containing 130
CCDC86 coiled-coil domain containing 86
CD151 CD151 molecule (Raph blood group)
CD248 CD248 molecule, endosialin
CD320 CD320 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDT1 chromatin licensing and DNA replication factor 1
CES1 carboxylesterase 1
CNR2 cannabinoid receptor 2 (macrophage)
CRYBB2P1 crystallin, beta B2 pseudogene 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEAF1 DEAF1 transcription factor
DPF2 D4, zinc and double PHD fingers family 2
DUSP5 dual specificity phosphatase 5
DYM dymeclin
DYSF dysferlin
EHD4 EH-domain containing 4
ELP3 elongator acetyltransferase complex subunit 3
FAM192A family with sequence similarity 192, member A
FAM46A family with sequence similarity 46, member A
FBXL6 F-box and leucine-rich repeat protein 6
FBXO46 F-box protein 46
FBXW4 F-box and WD repeat domain containing 4
FIG4 FIG4 phosphoinositide 5-phosphatase
FNBP4 formin binding protein 4
FOXM1 forkhead box M1
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GTPBP6 GTP binding protein 6 (putative)
HELLS helicase, lymphoid-specific
HRAS Harvey rat sarcoma viral oncogene homolog
IGFLR1 IGF-like family receptor 1
LUC7L LUC7-like (S. cerevisiae)
MAGEF1 melanoma antigen family F1
MAP1S microtubule-associated protein 1S
MAPK12 mitogen-activated protein kinase 12
MCM10 minichromosome maintenance complex component 10
MECR mitochondrial trans-2-enoyl-CoA reductase
METTL21B methyltransferase like 21B
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MT1HL1 metallothionein 1H-like 1
MTERF4 mitochondrial transcription termination factor 4
NCAPH non-SMC condensin I complex, subunit H
NCF1C neutrophil cytosolic factor 1C pseudogene
NISCH nischarin
NME6 NME/NM23 nucleoside diphosphate kinase 6
NPPA natriuretic peptide A
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUBP2 nucleotide binding protein 2
OVGP1 oviductal glycoprotein 1, 120kDa
PANK4 pantothenate kinase 4
PCSK7 proprotein convertase subtilisin/kexin type 7
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLXNA1 plexin A1
PMEL premelanosome protein
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRRC1 proline-rich coiled-coil 1
PSKH1 protein serine kinase H1
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RAD54L RAD54-like (S. cerevisiae)
RHOH ras homolog family member H
RNASE6 ribonuclease, RNase A family, k6
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
S1PR4 sphingosine-1-phosphate receptor 4
SFXN1 sideroflexin 1
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNF8 SNF8, ESCRT-II complex subunit
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRRD SRR1 domain containing
STRA13 stimulated by retinoic acid 13
TACC3 transforming, acidic coiled-coil containing protein 3
TERT telomerase reverse transcriptase
THAP4 THAP domain containing 4
TIPIN TIMELESS interacting protein
TMEM127 transmembrane protein 127
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPM2 transient receptor potential cation channel, subfamily M, member 2
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H3 zinc finger CCCH-type containing 3
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF217 zinc finger protein 217
ZNF35 zinc finger protein 35
ZNF408 zinc finger protein 408