perphenazine Gene Set

Dataset	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category	transcriptomics
Type	small molecule perturbation
Description	A member of the class of phenothiazines that is phenothiazine having a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position. (Chemical Entities of Biological Interest Ontology, CHEBI_8028)
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Genes

16 genes differentially expressed following the perphenazine small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol	Name	Standardized Value
INSIG1	insulin induced gene 1	6.3213
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	5.02134
GNPDA1	glucosamine-6-phosphate deaminase 1	4.58383
NPC1	Niemann-Pick disease, type C1	4.55879
TSC22D3	TSC22 domain family, member 3	3.93586
SCD	stearoyl-CoA desaturase (delta-9-desaturase)	3.71679
LSS	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	3.65244
SQLE	squalene epoxidase	3.55708
MSMO1	methylsterol monooxygenase 1	3.50265
FDPS	farnesyl diphosphate synthase	3.41931
FDFT1	farnesyl-diphosphate farnesyltransferase 1	3.39881
HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	3.36789
DHCR24	24-dehydrocholesterol reductase	3.18735
FADS1	fatty acid desaturase 1	3.17032
UAP1L1	UDP-N-acetylglucosamine pyrophosphorylase 1 like 1	3.07382

decreased expression

Symbol	Name	Standardized Value
JUN	jun proto-oncogene	-3.351