pf4 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description platelet factor 4|This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014] (NCBI Entrez Gene Database, 5196)
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Genes

21 genes co-occuring with the biological term pf4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
APOH apolipoprotein H (beta-2-glycoprotein I)
CCL5 chemokine (C-C motif) ligand 5
CPB2 carboxypeptidase B2 (plasma)
CTSG cathepsin G
ELF1 E74-like factor 1 (ets domain transcription factor)
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLT1 fms-related tyrosine kinase 1
KDR kinase insert domain receptor
PF4 platelet factor 4
PKNOX1 PBX/knotted 1 homeobox 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPBPP1 pro-platelet basic protein pseudogene 1
PROC protein C (inactivator of coagulation factors Va and VIIIa)
RUNX1 runt-related transcription factor 1
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
USF1 upstream transcription factor 1
USF2 upstream transcription factor 2, c-fos interacting
VEGFA vascular endothelial growth factor A