phenazone-4251 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the phenazone-4251 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APOE apolipoprotein E
B9D1 B9 protein domain 1
BLK BLK proto-oncogene, Src family tyrosine kinase
BLZF1 basic leucine zipper nuclear factor 1
C7 complement component 7
CALCR calcitonin receptor
CARD10 caspase recruitment domain family, member 10
CD1E CD1e molecule
CD226 CD226 molecule
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLSTN3 calsyntenin 3
COL11A1 collagen, type XI, alpha 1
COL4A6 collagen, type IV, alpha 6
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSC1 desmocollin 1
ESR1 estrogen receptor 1
EXO5 exonuclease 5
FAM63A family with sequence similarity 63, member A
FLT1 fms-related tyrosine kinase 1
FOXN3 forkhead box N3
GAB1 GRB2-associated binding protein 1
GGT1 gamma-glutamyltransferase 1
GIPC2 GIPC PDZ domain containing family, member 2
GK glycerol kinase
GK2 glycerol kinase 2
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPATCH4 G patch domain containing 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
GYPB glycophorin B (MNS blood group)
HAP1 huntingtin-associated protein 1
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HIST1H1D histone cluster 1, H1d
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
IL12RB2 interleukin 12 receptor, beta 2
IL1RN interleukin 1 receptor antagonist
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LDHC lactate dehydrogenase C
LEFTY1 left-right determination factor 1
LRRC2 leucine rich repeat containing 2
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAP2 microtubule-associated protein 2
MBD2 methyl-CpG binding domain protein 2
MBL2 mannose-binding lectin (protein C) 2, soluble
MCF2L MCF.2 cell line derived transforming sequence-like
METTL7A methyltransferase like 7A
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MST1 macrophage stimulating 1
MYF5 myogenic factor 5
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal
NAV3 neuron navigator 3
NCF4 neutrophil cytosolic factor 4, 40kDa
NEK9 NIMA-related kinase 9
NPTX1 neuronal pentraxin I
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR5A2 nuclear receptor subfamily 5, group A, member 2
OGDHL oxoglutarate dehydrogenase-like
PAX5 paired box 5
PCBP3 poly(rC) binding protein 3
PDE4DIP phosphodiesterase 4D interacting protein
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLCH2 phospholipase C, eta 2
PLD1 phospholipase D1, phosphatidylcholine-specific
PLXDC1 plexin domain containing 1
POU5F1B POU class 5 homeobox 1B
PQLC2 PQ loop repeat containing 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRR protein tyrosine phosphatase, receptor type, R
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RGS5 regulator of G-protein signaling 5
SEC31B SEC31 homolog B (S. cerevisiae)
SIRAL2 SIR2 antiphage like 2
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC35F5 solute carrier family 35, member F5
SMAD1 SMAD family member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SYNJ2 synaptojanin 2
TAGLN3 transgelin 3
TAS2R16 taste receptor, type 2, member 16
TBX5 T-box 5
TENM1 teneurin transmembrane protein 1
THBD thrombomodulin
TJP3 tight junction protein 3
TP63 tumor protein p63
TPM1 tropomyosin 1 (alpha)
TRIM3 tripartite motif containing 3
WDR62 WD repeat domain 62
ZC2HC1C zinc finger, C2HC-type containing 1C
ZC3H13 zinc finger CCCH-type containing 13
ZNF343 zinc finger protein 343
ZNF507 zinc finger protein 507

decreased expression

Symbol Name
ACE angiotensin I converting enzyme
ADAM23 ADAM metallopeptidase domain 23
ADGRB2 adhesion G protein-coupled receptor B2
AK5 adenylate kinase 5
ALOX12 arachidonate 12-lipoxygenase
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANKFY1 ankyrin repeat and FYVE domain containing 1
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
C22ORF29 chromosome 22 open reading frame 29
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN1 claudin 1
COMP cartilage oligomeric matrix protein
CUZD1 CUB and zona pellucida-like domains 1
CXCL3 chemokine (C-X-C motif) ligand 3
CXORF21 chromosome X open reading frame 21
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DOK5 docking protein 5
EFNA3 ephrin-A3
EGLN3 egl-9 family hypoxia-inducible factor 3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERO1LB ERO1-like beta (S. cerevisiae)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBXL15 F-box and leucine-rich repeat protein 15
FGF20 fibroblast growth factor 20
FRMPD1 FERM and PDZ domain containing 1
GDAP1 ganglioside induced differentiation associated protein 1
GLS2 glutaminase 2 (liver, mitochondrial)
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GREB1L growth regulation by estrogen in breast cancer-like
GTF2I general transcription factor IIi
HIST1H2BN histone cluster 1, H2bn
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HSPB6 heat shock protein, alpha-crystallin-related, B6
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFNA17 interferon, alpha 17
IGKV3-20 immunoglobulin kappa variable 3-20
IL12RB1 interleukin 12 receptor, beta 1
IL4R interleukin 4 receptor
IMPG1 interphotoreceptor matrix proteoglycan 1
IQSEC2 IQ motif and Sec7 domain 2
ITPKA inositol-trisphosphate 3-kinase A
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM8 lysine (K)-specific demethylase 8
KLF13 Kruppel-like factor 13
KLF3 Kruppel-like factor 3 (basic)
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LAX1 lymphocyte transmembrane adaptor 1
LENEP lens epithelial protein
LIME1 Lck interacting transmembrane adaptor 1
LINC00260 long intergenic non-protein coding RNA 260
LOC100287590 uncharacterized LOC100287590
LPAR4 lysophosphatidic acid receptor 4
LY6D lymphocyte antigen 6 complex, locus D
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MON1B MON1 secretory trafficking family member B
MTA2 metastasis associated 1 family, member 2
MTSS1L metastasis suppressor 1-like
MYO15A myosin XVA
NACA2 nascent polypeptide-associated complex alpha subunit 2
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PACS1 phosphofurin acidic cluster sorting protein 1
PALM paralemmin
PARP11 poly (ADP-ribose) polymerase family, member 11
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PEX26 peroxisomal biogenesis factor 26
PHEX phosphate regulating endopeptidase homolog, X-linked
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRICKLE3 prickle homolog 3 (Drosophila)
PRM2 protamine 2
PROL1 proline rich, lacrimal 1
RAPSN receptor-associated protein of the synapse
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCIN scinderin
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC12A8 solute carrier family 12, member 8
SLC16A6 solute carrier family 16, member 6
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMR3A submaxillary gland androgen regulated protein 3A
SSBP3 single stranded DNA binding protein 3
TEX15 testis expressed 15
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM212 transmembrane protein 212
TNNI3 troponin I type 3 (cardiac)
TRAC T cell receptor alpha constant
TSC22D4 TSC22 domain family, member 4
UBTD1 ubiquitin domain containing 1
UNC93B1 unc-93 homolog B1 (C. elegans)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZNF222 zinc finger protein 222
ZNF667 zinc finger protein 667
ZNF749 zinc finger protein 749