phentolamine-1138 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the phentolamine-1138 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ADCK3 aarF domain containing kinase 3
AKAP13 A kinase (PRKA) anchor protein 13
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ATM ATM serine/threonine kinase
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATXN1 ataxin 1
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BMP7 bone morphogenetic protein 7
C16ORF62 chromosome 16 open reading frame 62
C19ORF54 chromosome 19 open reading frame 54
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CALHM2 calcium homeostasis modulator 2
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CDC40 cell division cycle 40
CLEC16A C-type lectin domain family 16, member A
CPT1A carnitine palmitoyltransferase 1A (liver)
CTTN cortactin
CYB561 cytochrome b561
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCAF15 DDB1 and CUL4 associated factor 15
DNAAF2 dynein, axonemal, assembly factor 2
DNMBP dynamin binding protein
DPH5 diphthamide biosynthesis 5
ELF4 E74-like factor 4 (ets domain transcription factor)
FASTK Fas-activated serine/threonine kinase
FKBP2 FK506 binding protein 2, 13kDa
FNTB farnesyltransferase, CAAX box, beta
FPGS folylpolyglutamate synthase
GLIPR1 GLI pathogenesis-related 1
GPR19 G protein-coupled receptor 19
GSTM1 glutathione S-transferase mu 1
HEMK1 HemK methyltransferase family member 1
HIST1H2BG histone cluster 1, H2bg
HLA-E major histocompatibility complex, class I, E
HMOX2 heme oxygenase 2
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA2 heat shock 70kDa protein 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ITM2B integral membrane protein 2B
JUN jun proto-oncogene
KAT5 K(lysine) acetyltransferase 5
LYPLA2 lysophospholipase II
MARC2 mitochondrial amidoxime reducing component 2
MECP2 methyl CpG binding protein 2
MED14 mediator complex subunit 14
MTA1 metastasis associated 1
MTCL1 microtubule crosslinking factor 1
MTHFSD methenyltetrahydrofolate synthetase domain containing
MXD3 MAX dimerization protein 3
NAT9 N-acetyltransferase 9 (GCN5-related, putative)
NOTCH1 notch 1
OSBP oxysterol binding protein
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDLIM7 PDZ and LIM domain 7 (enigma)
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PODXL podocalyxin-like
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)
POMZP3 POM121 and ZP3 fusion
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRUNE prune exopolyphosphatase
RAP1GAP RAP1 GTPase activating protein
RHOF ras homolog family member F (in filopodia)
RHOT2 ras homolog family member T2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SIKE1 suppressor of IKBKE 1
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SPTBN1 spectrin, beta, non-erythrocytic 1
STBD1 starch binding domain 1
STC1 stanniocalcin 1
STK10 serine/threonine kinase 10
SUGP1 SURP and G patch domain containing 1
SYK spleen tyrosine kinase
TELO2 telomere maintenance 2
THAP1 THAP domain containing, apoptosis associated protein 1
TMEM115 transmembrane protein 115
TMEM39B transmembrane protein 39B
TRAPPC6A trafficking protein particle complex 6A
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBAP1 ubiquitin associated protein 1
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
ZBTB14 zinc finger and BTB domain containing 14
ZNF318 zinc finger protein 318
ZNF574 zinc finger protein 574
ZNF580 zinc finger protein 580
ZNF75D zinc finger protein 75D
ZNF813 zinc finger protein 813
ZYX zyxin

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARHGAP11A Rho GTPase activating protein 11A
ARID4A AT rich interactive domain 4A (RBP1-like)
ATAD3A ATPase family, AAA domain containing 3A
ATAD5 ATPase family, AAA domain containing 5
ATG7 autophagy related 7
ATP11B ATPase, class VI, type 11B
AXIN1 axin 1
AZI2 5-azacytidine induced 2
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCL2L2 BCL2-like 2
BLM Bloom syndrome, RecQ helicase-like
C11ORF95 chromosome 11 open reading frame 95
C9ORF91 chromosome 9 open reading frame 91
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CBX4 chromobox homolog 4
CCDC176 coiled-coil domain containing 176
CCNJ cyclin J
CDK5 cyclin-dependent kinase 5
CENPJ centromere protein J
CENPT centromere protein T
CEP83 centrosomal protein 83kDa
CLASRP CLK4-associating serine/arginine rich protein
CLDND1 claudin domain containing 1
CPTP ceramide-1-phosphate transfer protein
CRBN cereblon
CRYL1 crystallin, lambda 1
DCAF10 DDB1 and CUL4 associated factor 10
DCP1A decapping mRNA 1A
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DDB1 damage-specific DNA binding protein 1, 127kDa
DMTF1 cyclin D binding myb-like transcription factor 1
DMXL1 Dmx-like 1
EDC4 enhancer of mRNA decapping 4
EPPK1 epiplakin 1
FEM1C fem-1 homolog c (C. elegans)
FLJ10038 uncharacterized protein FLJ10038
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GAB2 GRB2-associated binding protein 2
GLMN glomulin, FKBP associated protein
GMPPA GDP-mannose pyrophosphorylase A
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
GUSBP3 glucuronidase, beta pseudogene 3
HMBOX1 homeobox containing 1
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IL10RB interleukin 10 receptor, beta
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
IPP intracisternal A particle-promoted polypeptide
ITPKC inositol-trisphosphate 3-kinase C
KIAA0125 KIAA0125
KIF3A kinesin family member 3A
KLK6 kallikrein-related peptidase 6
LAMA5 laminin, alpha 5
LIN37 lin-37 DREAM MuvB core complex component
LRRC16A leucine rich repeat containing 16A
MANSC1 MANSC domain containing 1
MICB MHC class I polypeptide-related sequence B
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MPST mercaptopyruvate sulfurtransferase
MRPL17 mitochondrial ribosomal protein L17
NIT1 nitrilase 1
NPY1R neuropeptide Y receptor Y1
NT5C 5', 3'-nucleotidase, cytosolic
NUBPL nucleotide binding protein-like
PARP6 poly (ADP-ribose) polymerase family, member 6
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PPCDC phosphopantothenoylcysteine decarboxylase
PRKCH protein kinase C, eta
PRPF39 pre-mRNA processing factor 39
PTCD2 pentatricopeptide repeat domain 2
RBM6 RNA binding motif protein 6
RPL23AP7 ribosomal protein L23a pseudogene 7
RUFY2 RUN and FYVE domain containing 2
SETD6 SET domain containing 6
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SIRAL2 SIR2 antiphage like 2
SIRT1 sirtuin 1
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC35A5 solute carrier family 35, member A5
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBCCD1 TBCC domain containing 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TM7SF3 transmembrane 7 superfamily member 3
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM57 transmembrane protein 57
TRAPPC2 trafficking protein particle complex 2
TRIM52 tripartite motif containing 52
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TTC17 tetratricopeptide repeat domain 17
TTI1 TELO2 interacting protein 1
UBIAD1 UbiA prenyltransferase domain containing 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
USP6 ubiquitin specific peptidase 6
WDR60 WD repeat domain 60
YAP1 Yes-associated protein 1
ZNF611 zinc finger protein 611
ZNF85 zinc finger protein 85