phentolamine-3860 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the phentolamine-3860 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ADGRG1 adhesion G protein-coupled receptor G1
AGFG2 ArfGAP with FG repeats 2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ASPH aspartate beta-hydroxylase
CA9 carbonic anhydrase IX
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CDC14A cell division cycle 14A
CDC25A cell division cycle 25A
CDRT1 CMT1A duplicated region transcript 1
CPQ carboxypeptidase Q
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTIF CBP80/20-dependent translation initiation factor
DAPK3 death-associated protein kinase 3
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DICER1 dicer 1, ribonuclease type III
DSC2 desmocollin 2
DST dystonin
DUSP4 dual specificity phosphatase 4
E2F2 E2F transcription factor 2
EGR1 early growth response 1
EXPH5 exophilin 5
FADS2 fatty acid desaturase 2
FAM169A family with sequence similarity 169, member A
FGFR1 fibroblast growth factor receptor 1
FKRP fukutin related protein
FUT2 fucosyltransferase 2 (secretor status included)
GPATCH4 G patch domain containing 4
GSN gelsolin
GTPBP3 GTP binding protein 3 (mitochondrial)
HIST1H2AK histone cluster 1, H2ak
HOXA11 homeobox A11
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IL17RC interleukin 17 receptor C
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KIF25 kinesin family member 25
KITLG KIT ligand
KLF13 Kruppel-like factor 13
KLHL25 kelch-like family member 25
KMT2A lysine (K)-specific methyltransferase 2A
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MFSD6 major facilitator superfamily domain containing 6
MRPL41 mitochondrial ribosomal protein L41
MST1 macrophage stimulating 1
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NCOR2 nuclear receptor corepressor 2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU3 sialidase 3 (membrane sialidase)
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NGLY1 N-glycanase 1
NME5 NME/NM23 family member 5
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUP188 nucleoporin 188kDa
PCM1 pericentriolar material 1
PDAP1 PDGFA associated protein 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLXNB3 plexin B3
PPIA peptidylprolyl isomerase A (cyclophilin A)
PROCR protein C receptor, endothelial
PRSS53 protease, serine, 53
PSG1 pregnancy specific beta-1-glycoprotein 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBM34 RNA binding motif protein 34
RBM5 RNA binding motif protein 5
RBP4 retinol binding protein 4, plasma
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RORC RAR-related orphan receptor C
RPS3A ribosomal protein S3A
RRBP1 ribosome binding protein 1
SDS serine dehydratase
SELL selectin L
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SIRT4 sirtuin 4
SIRT5 sirtuin 5
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SPHK2 sphingosine kinase 2
SPTBN5 spectrin, beta, non-erythrocytic 5
SRF serum response factor (c-fos serum response element-binding transcription factor)
STOML1 stomatin (EPB72)-like 1
STS steroid sulfatase (microsomal), isozyme S
STX16 syntaxin 16
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM212 transmembrane protein 212
TOP3A topoisomerase (DNA) III alpha
TP63 tumor protein p63
TPMT thiopurine S-methyltransferase
TWF1 twinfilin actin binding protein 1
ZCCHC4 zinc finger, CCHC domain containing 4
ZER1 zyg-11 related, cell cycle regulator
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
AMH anti-Mullerian hormone
AMPD1 adenosine monophosphate deaminase 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARR3 arrestin 3, retinal (X-arrestin)
ARRB1 arrestin, beta 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
C14ORF93 chromosome 14 open reading frame 93
C19ORF73 chromosome 19 open reading frame 73
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C5 complement component 5
C8ORF44 chromosome 8 open reading frame 44
CALB2 calbindin 2
CD80 CD80 molecule
CD82 CD82 molecule
CFAP45 cilia and flagella associated protein 45
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CORT cortistatin
CRLF1 cytokine receptor-like factor 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSF cathepsin F
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DNAH17 dynein, axonemal, heavy chain 17
DUSP9 dual specificity phosphatase 9
DYM dymeclin
ECH1 enoyl CoA hydratase 1, peroxisomal
EMID1 EMI domain containing 1
ENO3 enolase 3 (beta, muscle)
ENOX1 ecto-NOX disulfide-thiol exchanger 1
EPHB6 EPH receptor B6
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXO2 F-box protein 2
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGF23 fibroblast growth factor 23
FLJ22184
FXYD5 FXYD domain containing ion transport regulator 5
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GSTM2 glutathione S-transferase mu 2 (muscle)
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HIST1H4C histone cluster 1, H4c
HIST1H4E histone cluster 1, H4e
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HYI hydroxypyruvate isomerase (putative)
IL17RA interleukin 17 receptor A
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
ITPKB inositol-trisphosphate 3-kinase B
KCNK12 potassium channel, two pore domain subfamily K, member 12
KRT15 keratin 15, type I
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MUTYH mutY homolog
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
NCALD neurocalcin delta
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPPA natriuretic peptide A
NPTX1 neuronal pentraxin I
PACS1 phosphofurin acidic cluster sorting protein 1
PAOX polyamine oxidase (exo-N4-amino)
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PMEL premelanosome protein
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
RAB40C RAB40C, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RETN resistin
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SECTM1 secreted and transmembrane 1
SIPA1 signal-induced proliferation-associated 1
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SPINK5 serine peptidase inhibitor, Kazal type 5
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STARD5 StAR-related lipid transfer (START) domain containing 5
SYNDIG1 synapse differentiation inducing 1
TARP TCR gamma alternate reading frame protein
TEX40 testis expressed 40
TGFB1I1 transforming growth factor beta 1 induced transcript 1
THRAP3 thyroid hormone receptor associated protein 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOR4A torsin family 4, member A
TRIM68 tripartite motif containing 68
TUBA3C tubulin, alpha 3c
UPP1 uridine phosphorylase 1
VASH1 vasohibin 1
VIM vimentin
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZDHHC14 zinc finger, DHHC-type containing 14
ZDHHC24 zinc finger, DHHC-type containing 24
ZNF358 zinc finger protein 358
ZNF639 zinc finger protein 639