phenylpropanolamine-3217 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the phenylpropanolamine-3217 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACPP acid phosphatase, prostate
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADORA1 adenosine A1 receptor
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ALPPL2 alkaline phosphatase, placental-like 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
BEX1 brain expressed, X-linked 1
C2ORF27A chromosome 2 open reading frame 27A
CD4 CD4 molecule
CD53 CD53 molecule
CD58 CD58 molecule
CLEC2B C-type lectin domain family 2, member B
CNTN5 contactin 5
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYHR1 cysteine/histidine-rich 1
DENND1C DENN/MADD domain containing 1C
EFNB3 ephrin-B3
ELANE elastase, neutrophil expressed
EVI2A ecotropic viral integration site 2A
EXPH5 exophilin 5
FAM129A family with sequence similarity 129, member A
FAM198B family with sequence similarity 198, member B
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
GMFG glia maturation factor, gamma
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPX1 glutathione peroxidase 1
GSTP1 glutathione S-transferase pi 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HLA-B major histocompatibility complex, class I, B
IGL immunoglobulin lambda locus
IL17RC interleukin 17 receptor C
IPCEF1 interaction protein for cytohesin exchange factors 1
IRF8 interferon regulatory factor 8
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13
KIF21B kinesin family member 21B
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAPTM5 lysosomal protein transmembrane 5
LDHB lactate dehydrogenase B
LMO2 LIM domain only 2 (rhombotin-like 1)
LPL lipoprotein lipase
LST1 leukocyte specific transcript 1
LTC4S leukotriene C4 synthase
LYZ lysozyme
MARK4 MAP/microtubule affinity-regulating kinase 4
MNDA myeloid cell nuclear differentiation antigen
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSN moesin
MYBPC3 myosin binding protein C, cardiac
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NCR2 natural cytotoxicity triggering receptor 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PITX1 paired-like homeodomain 1
PLAC8 placenta-specific 8
PLEK pleckstrin
PRAME preferentially expressed antigen in melanoma
PRB3 proline-rich protein BstNI subfamily 3
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PROL1 proline rich, lacrimal 1
PRTN3 proteinase 3
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB3B RAB3B, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RGS1 regulator of G-protein signaling 1
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE3 ribonuclease, RNase A family, 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SETD8 SET domain containing (lysine methyltransferase) 8
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIRT5 sirtuin 5
SLC38A7 solute carrier family 38, member 7
SLC43A3 solute carrier family 43, member 3
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SP100 SP100 nuclear antigen
SPAG16 sperm associated antigen 16
SRGN serglycin
SSX1 synovial sarcoma, X breakpoint 1
ST18 suppression of tumorigenicity 18, zinc finger
STIM1 stromal interaction molecule 1
THBD thrombomodulin
TRIM36 tripartite motif containing 36
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TYROBP TYRO protein tyrosine kinase binding protein
VIM vimentin
WIPF1 WAS/WASL interacting protein family, member 1
WNT16 wingless-type MMTV integration site family, member 16
WSB1 WD repeat and SOCS box containing 1
ZEB1 zinc finger E-box binding homeobox 1

decreased expression

Symbol Name
ADCY7 adenylate cyclase 7
AFF4 AF4/FMR2 family, member 4
ALOX15 arachidonate 15-lipoxygenase
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD40 ankyrin repeat domain 40
APLP1 amyloid beta (A4) precursor-like protein 1
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARPIN actin-related protein 2/3 complex inhibitor
ARSB arylsulfatase B
ART1 ADP-ribosyltransferase 1
ASAP1-IT1 ASAP1 intronic transcript 1
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAHCC1 BAH domain and coiled-coil containing 1
BMP4 bone morphogenetic protein 4
C14ORF105 chromosome 14 open reading frame 105
CBX8 chromobox homolog 8
CD79B CD79b molecule, immunoglobulin-associated beta
CDK20 cyclin-dependent kinase 20
CDON cell adhesion associated, oncogene regulated
CENPO centromere protein O
CEP162 centrosomal protein 162kDa
CGREF1 cell growth regulator with EF-hand domain 1
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CXORF56 chromosome X open reading frame 56
DAGLA diacylglycerol lipase, alpha
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DMTN dematin actin binding protein
DNM1 dynamin 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPY19L1P1 DPY19L1 pseudogene 1
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EIF5A2 eukaryotic translation initiation factor 5A2
FAM131A family with sequence similarity 131, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FSTL3 follistatin-like 3 (secreted glycoprotein)
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GIF gastric intrinsic factor (vitamin B synthesis)
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GPC3 glypican 3
GRB7 growth factor receptor-bound protein 7
GTPBP2 GTP binding protein 2
HAMP hepcidin antimicrobial peptide
HIST1H2AK histone cluster 1, H2ak
HIST1H2BM histone cluster 1, H2bm
HLA-DMA major histocompatibility complex, class II, DM alpha
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IL17RA interleukin 17 receptor A
IL4R interleukin 4 receptor
INF2 inverted formin, FH2 and WH2 domain containing
IQSEC2 IQ motif and Sec7 domain 2
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIAA0754 KIAA0754
LNPEP leucyl/cystinyl aminopeptidase
LZTS3 leucine zipper, putative tumor suppressor family member 3
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MTSS1L metastasis suppressor 1-like
MUC3A mucin 3A, cell surface associated
MUC3B mucin 3B, cell surface associated
NLRX1 NLR family member X1
NRSN2 neurensin 2
OLFML2A olfactomedin-like 2A
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PCDHA6 protocadherin alpha 6
PHC1 polyhomeotic homolog 1 (Drosophila)
PODNL1 podocan-like 1
POLL polymerase (DNA directed), lambda
POMT2 protein-O-mannosyltransferase 2
PPAN peter pan homolog (Drosophila)
PRICKLE3 prickle homolog 3 (Drosophila)
PRR4 proline rich 4 (lacrimal)
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PTPN14 protein tyrosine phosphatase, non-receptor type 14
R3HCC1L R3H domain and coiled-coil containing 1-like
REM1 RAS (RAD and GEM)-like GTP-binding 1
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SAYSD1 SAYSVFN motif domain containing 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
STAB2 stabilin 2
STARD5 StAR-related lipid transfer (START) domain containing 5
SYCP2 synaptonemal complex protein 2
TBC1D17 TBC1 domain family, member 17
TEP1 telomerase-associated protein 1
TET3 tet methylcytosine dioxygenase 3
THBS3 thrombospondin 3
TMC7 transmembrane channel-like 7
UNC119 unc-119 homolog (C. elegans)
VGF VGF nerve growth factor inducible
ZNF211 zinc finger protein 211
ZNF250 zinc finger protein 250
ZNF365 zinc finger protein 365
ZNF510 zinc finger protein 510
ZNF696 zinc finger protein 696
ZSCAN26 zinc finger and SCAN domain containing 26