phenylpropanolamine-6699 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the phenylpropanolamine-6699 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AADAC arylacetamide deacetylase
AAGAB alpha- and gamma-adaptin binding protein
ACOX3 acyl-CoA oxidase 3, pristanoyl
ADAP2 ArfGAP with dual PH domains 2
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
AIF1 allograft inflammatory factor 1
APC adenomatous polyposis coli
ATG10 autophagy related 10
BMP7 bone morphogenetic protein 7
C10ORF10 chromosome 10 open reading frame 10
C2CD2L C2CD2-like
CA1 carbonic anhydrase I
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CD6 CD6 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CEP135 centrosomal protein 135kDa
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CLSTN3 calsyntenin 3
CNGA1 cyclic nucleotide gated channel alpha 1
CNOT4 CCR4-NOT transcription complex, subunit 4
CTAGE5 CTAGE family, member 5
CUBN cubilin (intrinsic factor-cobalamin receptor)
DZIP1 DAZ interacting zinc finger protein 1
EBF2 early B-cell factor 2
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
ETV1 ets variant 1
FAM162A family with sequence similarity 162, member A
FAM214B family with sequence similarity 214, member B
FOSL2 FOS-like antigen 2
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GPER1 G protein-coupled estrogen receptor 1
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
GZMK granzyme K (granzyme 3; tryptase II)
HIST1H4H histone cluster 1, H4h
HSPB6 heat shock protein, alpha-crystallin-related, B6
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL11 interleukin 11
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNMB2 potassium channel subfamily M regulatory beta subunit 2
KIAA1467 KIAA1467
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LCMT2 leucine carboxyl methyltransferase 2
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LMX1B LIM homeobox transcription factor 1, beta
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LYPD1 LY6/PLAUR domain containing 1
MAP2K6 mitogen-activated protein kinase kinase 6
MED16 mediator complex subunit 16
MMP11 matrix metallopeptidase 11
MYOZ3 myozenin 3
N4BP2L2 NEDD4 binding protein 2-like 2
NF1 neurofibromin 1
NNMT nicotinamide N-methyltransferase
NOD2 nucleotide-binding oligomerization domain containing 2
NPY2R neuropeptide Y receptor Y2
NUDC nudC nuclear distribution protein
PADI1 peptidyl arginine deiminase, type I
PAQR5 progestin and adipoQ receptor family member V
PGM5 phosphoglucomutase 5
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PSKH1 protein serine kinase H1
PTCH2 patched 2
RARG retinoic acid receptor, gamma
RHOT2 ras homolog family member T2
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RPL35A ribosomal protein L35a
RUNX1 runt-related transcription factor 1
SEC14L4 SEC14-like 4 (S. cerevisiae)
SFRP5 secreted frizzled-related protein 5
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIGLEC6 sialic acid binding Ig-like lectin 6
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SP1 Sp1 transcription factor
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SSX3 synovial sarcoma, X breakpoint 3
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
THRB thyroid hormone receptor, beta
TIMP4 TIMP metallopeptidase inhibitor 4
TRD T cell receptor delta locus
TRIM49 tripartite motif containing 49
TSC22D3 TSC22 domain family, member 3
TUBA3C tubulin, alpha 3c
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VCAN versican
WNT3 wingless-type MMTV integration site family, member 3
ZFP30 ZFP30 zinc finger protein
ZNF609 zinc finger protein 609
ZNF639 zinc finger protein 639
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAG4 BCL2-associated athanogene 4
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C17ORF53 chromosome 17 open reading frame 53
C1ORF56 chromosome 1 open reading frame 56
C1RL complement component 1, r subcomponent-like
C22ORF46 chromosome 22 open reading frame 46
C4ORF29 chromosome 4 open reading frame 29
CCL27 chemokine (C-C motif) ligand 27
CDK3 cyclin-dependent kinase 3
CGA glycoprotein hormones, alpha polypeptide
CHRDL1 chordin-like 1
CLCA1 chloride channel accessory 1
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CRYBA2 crystallin, beta A2
DCLRE1B DNA cross-link repair 1B
DDN dendrin
DHODH dihydroorotate dehydrogenase (quinone)
DMTN dematin actin binding protein
DNAH7 dynein, axonemal, heavy chain 7
DPF3 D4, zinc and double PHD fingers, family 3
DPYS dihydropyrimidinase
EPN3 epsin 3
FAM86C1 family with sequence similarity 86, member C1
FAT4 FAT atypical cadherin 4
FKBP10 FK506 binding protein 10, 65 kDa
FKBP5 FK506 binding protein 5
GBX2 gastrulation brain homeobox 2
GRAMD1C GRAM domain containing 1C
GSTA3 glutathione S-transferase alpha 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2AK histone cluster 1, H2ak
HIST1H2BN histone cluster 1, H2bn
HIST2H2AA3 histone cluster 2, H2aa3
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOOK1 hook microtubule-tethering protein 1
IER3IP1 immediate early response 3 interacting protein 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IQSEC2 IQ motif and Sec7 domain 2
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KIAA1107 KIAA1107
KLHL4 kelch-like family member 4
KRT9 keratin 9, type I
LMO7 LIM domain 7
LOC729164 hCG1732469
LPAR4 lysophosphatidic acid receptor 4
LRRC61 leucine rich repeat containing 61
MMP9 matrix metallopeptidase 9
MMRN2 multimerin 2
MRPL41 mitochondrial ribosomal protein L41
MTSS1L metastasis suppressor 1-like
NAT6 N-acetyltransferase 6 (GCN5-related)
NKX3-2 NK3 homeobox 2
NPFFR1 neuropeptide FF receptor 1
NPM3 nucleophosmin/nucleoplasmin 3
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PACS1 phosphofurin acidic cluster sorting protein 1
PCDH12 protocadherin 12
PDE8B phosphodiesterase 8B
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PRB3 proline-rich protein BstNI subfamily 3
PRSS22 protease, serine, 22
PRSS53 protease, serine, 53
PTK7 protein tyrosine kinase 7 (inactive)
QSER1 glutamine and serine rich 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAG2 recombination activating gene 2
RAPSN receptor-associated protein of the synapse
REM1 RAS (RAD and GEM)-like GTP-binding 1
RIBC2 RIB43A domain with coiled-coils 2
RPL13P5 ribosomal protein L13 pseudogene 5
RUSC2 RUN and SH3 domain containing 2
SCAMP5 secretory carrier membrane protein 5
SCIN scinderin
SCN10A sodium channel, voltage gated, type X alpha subunit
SCUBE3 signal peptide, CUB domain, EGF-like 3
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLMO1 slowmo homolog 1 (Drosophila)
SOBP sine oculis binding protein homolog (Drosophila)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SYT17 synaptotagmin XVII
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCEAL2 transcription elongation factor A (SII)-like 2
TIGD6 tigger transposable element derived 6
TINAGL1 tubulointerstitial nephritis antigen-like 1
USP27X ubiquitin specific peptidase 27, X-linked
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZBTB22 zinc finger and BTB domain containing 22
ZNF324 zinc finger protein 324
ZNF492 zinc finger protein 492
ZNF668 zinc finger protein 668
ZNF675 zinc finger protein 675
ZNF778 zinc finger protein 778