pheochromocytoma Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system that secretes catecholamines. It arises from the chromaffin cells of the adrenal medulla. Clinical presentation includes headaches, palpitations, chest and abdominal pain, hypertension, fever, and tremor. Microscopically, a characteristic nesting (zellballen) growth pattern is usually seen. Other growth patterns including trabecular pattern may also be present. (Experimental Factor Ontology, EFO_0000239)
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Genes

38 genes co-occuring with the biological term pheochromocytoma in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADRB3 adrenoceptor beta 3
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHGA chromogranin A
COL18A1 collagen, type XVIII, alpha 1
EPAS1 endothelial PAS domain protein 1
FH fumarate hydratase
FLT1 fms-related tyrosine kinase 1
GAL galanin/GMAP prepropeptide
GALR2 galanin receptor 2
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IL13RA2 interleukin 13 receptor, alpha 2
INHA inhibin, alpha
KDR kinase insert domain receptor
LGALS3 lectin, galactoside-binding, soluble, 3
MAX MYC associated factor X
NF1 neurofibromin 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
POU5F1 POU class 5 homeobox 1
PRDM16 PR domain containing 16
RET ret proto-oncogene
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SPP1 secreted phosphoprotein 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TERT telomerase reverse transcriptase
TMEM127 transmembrane protein 127
TP53 tumor protein p53
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UTS2 urotensin 2
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase