phosphatidylinositol 3-kinase complex, class i Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A phosphatidylinositol 3-kinase complex that contains a catalytic and a regulatory subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme, plus one or more adaptor proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. The class I PI3K subfamily of genes comprises members in vertebrates, worm and fly, but none in yeast. (Gene Ontology, GO_0097651)
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55 proteins co-occuring with the phosphatidylinositol 3-kinase complex, class i cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.83815
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.63717
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.54744
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.11327
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.907855
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 0.715458
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.648506
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.50635
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.429662
PLEK pleckstrin 0.403831
PTEN phosphatase and tensin homolog 0.354232
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.340206
CCNF cyclin F 0.326266
TNS1 tensin 1 0.312597
IMMT inner membrane protein, mitochondrial 0.24713
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 0.237221
CCL11 chemokine (C-C motif) ligand 11 0.184241
CSF1R colony stimulating factor 1 receptor 0.16353
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.16309
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.156951
CSF1 colony stimulating factor 1 (macrophage) 0.149434
INS insulin 0.14938
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.14749
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) 0.146666
RILP Rab interacting lysosomal protein 0.146486
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.143543
CSH2 chorionic somatomammotropin hormone 2 0.14288
IRS2 insulin receptor substrate 2 0.142507
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 0.142038
RAG2 recombination activating gene 2 0.141962
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 0.141872
BTK Bruton agammaglobulinemia tyrosine kinase 0.141609
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 0.141257
SNAI2 snail family zinc finger 2 0.141233
INPPL1 inositol polyphosphate phosphatase-like 1 0.141178
A1BG alpha-1-B glycoprotein 0.14045
GAB2 GRB2-associated binding protein 2 0.140432
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.140217
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.140162
VAV2 vav 2 guanine nucleotide exchange factor 0.140134
NF1 neurofibromin 1 0.140031
TLR6 toll-like receptor 6 0.13977
SYK spleen tyrosine kinase 0.139414
EGFR epidermal growth factor receptor 0.139244
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.139025
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.138036
C5AR1 complement component 5a receptor 1 0.138011
CAPNS1 calpain, small subunit 1 0.137998
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.137882
TAT tyrosine aminotransferase 0.137065
TLR1 toll-like receptor 1 0.136596
SELE selectin E 0.136536
MAPK14 mitogen-activated protein kinase 14 0.136414
IRS1 insulin receptor substrate 1 0.136166
CCND2 cyclin D2 0.13604