phosphoric ester hydrolase activity Gene Set

Dataset GO Molecular Function Annotations 2025
Category structural or functional annotations
Type molecular function
Description Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. (Gene Ontology, GO_0042578)
External Link http://amigo.geneontology.org/amigo/term/GO:0042578
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Genes

53 genes performing the phosphoric ester hydrolase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

Symbol Name
ACP3 acid phosphatase 3
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
ARMT1 acidic residue methyltransferase 1
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
DUSP10 dual specificity phosphatase 10
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
DUSP12 dual specificity phosphatase 12
DUSP13A dual specificity phosphatase 13A
DUSP13B dual specificity phosphatase 13B
DUSP15 dual specificity phosphatase 15
DUSP16 dual specificity phosphatase 16
DUSP18 dual specificity phosphatase 18
DUSP28 dual specificity phosphatase 28
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP8 dual specificity phosphatase 8
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7
EPHX2 epoxide hydrolase 2, cytoplasmic
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
HDHD2 haloacid dehalogenase-like hydrolase domain containing 2
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
MPPED2 metallophosphoesterase domain containing 2
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1
PANK4 pantothenate kinase 4
PHOSPHO1 phosphatase, orphan 1
PHOSPHO2 phosphatase, orphan 2
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP5C protein phosphatase 5, catalytic subunit
PRUNE1 prune exopolyphosphatase 1
PTPMT1 protein tyrosine phosphatase, mitochondrial 1
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRM protein tyrosine phosphatase, receptor type, M
PTPRU protein tyrosine phosphatase, receptor type, U
PUDP pseudouridine 5'-phosphatase
PXYLP1 2-phosphoxylose phosphatase 1
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SBF1 SET binding factor 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B