pi-body Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
Description A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes. (Gene Ontology, GO_0071546)
External Link http://amigo.geneontology.org/amigo/term/GO:0071546
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Genes

269 proteins co-occuring with the pi-body cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
TDRD1 tudor domain containing 1 3.374
PIWIL2 piwi-like RNA-mediated gene silencing 2 3.291
TDRD9 tudor domain containing 9 3.115
TDRKH tudor and KH domain containing 3.027
PIWIL4 piwi-like RNA-mediated gene silencing 4 2.972
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.954
MAEL maelstrom spermatogenic transposon silencer 2.937
PLD6 phospholipase D family, member 6 2.909
TDRD6 tudor domain containing 6 2.846
TDRD5 tudor domain containing 5 2.79
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.757
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.693
TDRD7 tudor domain containing 7 2.682
RNF17 ring finger protein 17 2.599
HENMT1 HEN1 methyltransferase homolog 1 (Arabidopsis) 2.499
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 2.495
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 2.438
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.349
STK31 serine/threonine kinase 31 2.207
TDRD12 tudor domain containing 12 2.184
AGO3 argonaute RISC catalytic component 3 2.172
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.157
GTSF1 gametocyte specific factor 1 2.071
DCP1A decapping mRNA 1A 2.026
TSKS testis-specific serine kinase substrate 1.932
TNP1 transition protein 1 (during histone to protamine replacement) 1.861
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 1.855
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 1.846
PRM2 protamine 2 1.818
ADAD2 adenosine deaminase domain containing 2 1.813
TNP2 transition protein 2 (during histone to protamine replacement) 1.807
EXD2 exonuclease 3'-5' domain containing 2 1.801
XRN1 5'-3' exoribonuclease 1 1.8
TSSK2 testis-specific serine kinase 2 1.795
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 1.772
EXD1 exonuclease 3'-5' domain containing 1 1.766
NANOS3 nanos homolog 3 (Drosophila) 1.734
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 1.673
DICER1 dicer 1, ribonuclease type III 1.662
TSSK1B testis-specific serine kinase 1B 1.639
FBXO24 F-box protein 24 1.629
STRA8 stimulated by retinoic acid 8 1.57
TNRC6A trinucleotide repeat containing 6A 1.57
PRMT5 protein arginine methyltransferase 5 1.558
DND1 DND microRNA-mediated repression inhibitor 1 1.517
SYCP3 synaptonemal complex protein 3 1.516
DAZL deleted in azoospermia-like 1.511
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 1.497
ACRV1 acrosomal vesicle protein 1 1.493
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 1.477
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 1.449
MARF1 meiosis regulator and mRNA stability factor 1 1.421
MOV10 Mov10 RISC complex RNA helicase 1.412
ODF1 outer dense fiber of sperm tails 1 1.408
TDRD3 tudor domain containing 3 1.401
PIR pirin (iron-binding nuclear protein) 1.397
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 1.381
PABPC1 poly(A) binding protein, cytoplasmic 1 1.381
SPEM1 spermatid maturation 1 1.377
LPIN1 lipin 1 1.372
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 1.371
KIF17 kinesin family member 17 1.367
FAM107B family with sequence similarity 107, member B 1.366
TEX15 testis expressed 15 1.354
AGO2 argonaute RISC catalytic component 2 1.353
NANOS1 nanos homolog 1 (Drosophila) 1.343
SPOCD1 SPOC domain containing 1 1.341
NEUROG3 neurogenin 3 1.335
FKBP10 FK506 binding protein 10, 65 kDa 1.318
SMG6 SMG6 nonsense mediated mRNA decay factor 1.308
CREM cAMP responsive element modulator 1.307
TSSK6 testis-specific serine kinase 6 1.303
IPO5 importin 5 1.303
FKBP6 FK506 binding protein 6, 36kDa 1.301
CDK17 cyclin-dependent kinase 17 1.291
EIF4A3 eukaryotic translation initiation factor 4A3 1.256
AGO1 argonaute RISC catalytic component 1 1.252
PARN poly(A)-specific ribonuclease 1.25
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 1.219
EDC3 enhancer of mRNA decapping 3 1.212
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 1.211
KPNB1 karyopherin (importin) beta 1 1.209
EXD3 exonuclease 3'-5' domain containing 3 1.199
BOLL boule-like RNA-binding protein 1.168
NANOS2 nanos homolog 2 (Drosophila) 1.162
NUCB1 nucleobindin 1 1.153
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) 1.14
EIF4E eukaryotic translation initiation factor 4E 1.14
RPL10L ribosomal protein L10-like 1.129
KLHL10 kelch-like family member 10 1.12
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 1.108
DAZ1 deleted in azoospermia 1 1.107
WDR77 WD repeat domain 77 1.096
UHRF1 ubiquitin-like with PHD and ring finger domains 1 1.094
DROSHA drosha, ribonuclease type III 1.087
SMCP sperm mitochondria-associated cysteine-rich protein 1.086
SMC1B structural maintenance of chromosomes 1B 1.075
GTSF1L gametocyte specific factor 1-like 1.065
SPATA19 spermatogenesis associated 19 1.06
SCARA3 scavenger receptor class A, member 3 1.057
PRAMEF12 PRAME family member 12 1.055
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) 1.051
CPEB4 cytoplasmic polyadenylation element binding protein 4 1.049
CPEB3 cytoplasmic polyadenylation element binding protein 3 1.042
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 1.029
YBX2 Y box binding protein 2 1.018
UNC119 unc-119 homolog (C. elegans) 1.014
PRAME preferentially expressed antigen in melanoma 1.013
ZNFX1 zinc finger, NFX1-type containing 1 0.996
SETDB1 SET domain, bifurcated 1 0.992
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.991
SPATA24 spermatogenesis associated 24 0.99
DMRT1 doublesex and mab-3 related transcription factor 1 0.985
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.982
CILK1 ciliogenesis associated kinase 1 0.98
BTBD18 BTB (POZ) domain containing 18 0.976
CASC3 cancer susceptibility candidate 3 0.962
SMG5 SMG5 nonsense mediated mRNA decay factor 0.959
SMG7 SMG7 nonsense mediated mRNA decay factor 0.956
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.956
RNF133 ring finger protein 133 0.955
MFN1 mitofusin 1 0.941
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.939
CPEB1 cytoplasmic polyadenylation element binding protein 1 0.938
TENT5B terminal nucleotidyltransferase 5B 0.938
ANKEF1 ankyrin repeat and EF-hand domain containing 1 0.937
SLC25A41 solute carrier family 25, member 41 0.935
HOXB1 homeobox B1 0.931
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.922
FYCO1 FYVE and coiled-coil domain containing 1 0.914
CUL9 cullin 9 0.914
PAIP1 poly(A) binding protein interacting protein 1 0.911
POTEF POTE ankyrin domain family, member F 0.91
GPR182 G protein-coupled receptor 182 0.91
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.89
MAGEA8 melanoma antigen family A8 0.889
ARMC12 armadillo repeat containing 12 0.884
SYCP1 synaptonemal complex protein 1 0.883
TEKT1 tektin 1 0.876
RNF144B ring finger protein 144B 0.871
DCP2 decapping mRNA 2 0.86
PHRF1 PHD and ring finger domains 1 0.859
TBC1D21 TBC1 domain family, member 21 0.858
FHL5 four and a half LIM domains 5 0.858
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.857
TUFM Tu translation elongation factor, mitochondrial 0.855
ZGLP1 zinc finger, GATA-like protein 1 0.852
MNS1 meiosis-specific nuclear structural 1 0.847
PUM1 pumilio RNA-binding family member 1 0.846
ALPL alkaline phosphatase, liver/bone/kidney 0.832
PABPC1L poly(A) binding protein, cytoplasmic 1-like 0.824
PAIP2 poly(A) binding protein interacting protein 2 0.821
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.815
MFN2 mitofusin 2 0.811
MORC1 MORC family CW-type zinc finger 1 0.809
PRDM14 PR domain containing 14 0.807
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 0.807
SND1 staphylococcal nuclease and tudor domain containing 1 0.798
PLD2 phospholipase D2 0.797
PPP1R42 protein phosphatase 1, regulatory subunit 42 0.794
SPAG8 sperm associated antigen 8 0.794
AMH anti-Mullerian hormone 0.785
TSSK3 testis-specific serine kinase 3 0.768
GK5 glycerol kinase 5 (putative) 0.765
PDPN podoplanin 0.764
UBQLNL ubiquilin-like 0.763
SNRNP48 small nuclear ribonucleoprotein 48kDa (U11/U12) 0.762
ALPG alkaline phosphatase, germ cell 0.761
IER3 immediate early response 3 0.755
SLC38A6 solute carrier family 38, member 6 0.751
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.74
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.731
EIF4E2 eukaryotic translation initiation factor 4E family member 2 0.722
TSSK4 testis-specific serine kinase 4 0.718
H2AX H2A.X variant histone 0.714
YTHDC2 YTH domain containing 2 0.706
MAGEA4 melanoma antigen family A4 0.705
QRICH2 glutamine rich 2 0.703
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 0.703
LDHC lactate dehydrogenase C 0.697
NXT1 nuclear transport factor 2-like export factor 1 0.693
H1-0 H1.0 linker histone 0.691
FXR1 fragile X mental retardation, autosomal homolog 1 0.691
MBD6 methyl-CpG binding domain protein 6 0.69
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.69
TUT4 terminal uridylyl transferase 4 0.689
H3-5 H3.5 histone 0.683
H3-7 H3.7 histone (putative) 0.683
H3C13 H3 clustered histone 13 0.683
H3-4 H3.4 histone, cluster member 0.682
H3C7 H3 clustered histone 7 0.675
H3-3B H3.3 histone B 0.673
AK9 adenylate kinase 9 0.671
TMED1 transmembrane emp24 protein transport domain containing 1 0.671
SGSM2 small G protein signaling modulator 2 0.67
CAPZA3 capping protein (actin filament) muscle Z-line, alpha 3 0.67
ALPP alkaline phosphatase, placental 0.668
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 0.665
ARMC10 armadillo repeat containing 10 0.665
DEXI Dexi homolog (mouse) 0.665
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 0.664
CATSPERZ catsper channel auxiliary subunit zeta 0.664
PAPOLB poly(A) polymerase beta (testis specific) 0.661
INSL3 insulin-like 3 (Leydig cell) 0.655
PLPPR3 phospholipid phosphatase related 3 0.645
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.642
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.638
MAGOHB mago-nashi homolog B (Drosophila) 0.635
RPLP0 ribosomal protein, large, P0 0.633
H4C7 H4 clustered histone 7 0.63
DSPP dentin sialophosphoprotein 0.621
DAPL1 death associated protein-like 1 0.617
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.616
H4C15 H4 clustered histone 15 0.613
MEIOC meiosis specific with coiled-coil domain 0.61
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.606
TCP11 t-complex 11, testis-specific 0.603
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 0.6
ANK2 ankyrin 2, neuronal 0.598
ASPG asparaginase 0.597
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.595
HRK harakiri, BCL2 interacting protein 0.594
MKRN2 makorin ring finger protein 2 0.592
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.591
CAPRIN2 caprin family member 2 0.589
NXF2 nuclear RNA export factor 2 0.586
SIDT1 SID1 transmembrane family, member 1 0.586
CYCS cytochrome c, somatic 0.582
NXF2B nuclear RNA export factor 2B 0.58
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.577
TEKT4 tektin 4 0.574
EIF4A2 eukaryotic translation initiation factor 4A2 0.573
GOLGA2 golgin A2 0.57
PUM2 pumilio RNA-binding family member 2 0.567
EIF6 eukaryotic translation initiation factor 6 0.566
THOC7 THO complex 7 0.566
TSPAN33 tetraspanin 33 0.566
ANK1 ankyrin 1, erythrocytic 0.566
PGK2 phosphoglycerate kinase 2 0.564
ZNF692 zinc finger protein 692 0.564
HNRNPF heterogeneous nuclear ribonucleoprotein F 0.562
TEX14 testis expressed 14 0.561
NGDN neuroguidin, EIF4E binding protein 0.558
PIMREG PICALM interacting mitotic regulator 0.557
HORMAD1 HORMA domain containing 1 0.556
BASP1 brain abundant, membrane attached signal protein 1 0.556
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.556
PRDM8 PR domain containing 8 0.555
EIF4A1 eukaryotic translation initiation factor 4A1 0.55
GPR12 G protein-coupled receptor 12 0.542
RBM6 RNA binding motif protein 6 0.539
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 0.536
NCBP1 nuclear cap binding protein subunit 1, 80kDa 0.536
WNT3 wingless-type MMTV integration site family, member 3 0.533
PRDM1 PR domain containing 1, with ZNF domain 0.532
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.53
FBN3 fibrillin 3 0.523
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.519
SPATA16 spermatogenesis associated 16 0.519
H1-7 H1.7 linker histone 0.518
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.516
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.515
ADGRA3 adhesion G protein-coupled receptor A3 0.515
WDFY1 WD repeat and FYVE domain containing 1 0.515
AMPD1 adenosine monophosphate deaminase 1 0.513
TRIM36 tripartite motif containing 36 0.506
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.504
ZBTB16 zinc finger and BTB domain containing 16 0.503
USP26 ubiquitin specific peptidase 26 0.503