pi3 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description peptidase inhibitor 3, skin-derived|This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014] (NCBI Entrez Gene Database, 5266)
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Genes

136 genes co-occuring with the biological term pi3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACTN1 actinin, alpha 1
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
AMBP alpha-1-microglobulin/bikunin precursor
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
AR androgen receptor
ASPH aspartate beta-hydroxylase
ATF1 activating transcription factor 1
ATG14 autophagy related 14
BAD BCL2-associated agonist of cell death
BMP2 bone morphogenetic protein 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CD14 CD14 molecule
CD274 CD274 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CDCP1 CUB domain containing protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COL1A2 collagen, type I, alpha 2
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSB cathepsin B
CXCR4 chemokine (C-X-C motif) receptor 4
DRD2 dopamine receptor D2
EDN3 endothelin 3
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EPHA8 EPH receptor A8
EPO erythropoietin
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV6 ets variant 6
F2 coagulation factor II (thrombin)
FLT4 fms-related tyrosine kinase 4
GAB2 GRB2-associated binding protein 2
GAS6 growth arrest-specific 6
GIPC1 GIPC PDZ domain containing family, member 1
GJA1 gap junction protein, alpha 1, 43kDa
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
HAMP hepcidin antimicrobial peptide
HBEGF heparin-binding EGF-like growth factor
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA4 heat shock 70kDa protein 4
HSPB1 heat shock 27kDa protein 1
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IL31RA interleukin 31 receptor A
IL7 interleukin 7
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB6 integrin, beta 6
JAK2 Janus kinase 2
KDR kinase insert domain receptor
LEP leptin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MET MET proto-oncogene, receptor tyrosine kinase
MIR10A microRNA 10a
MIR491 microRNA 491
MMP9 matrix metallopeptidase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MXD1 MAX dimerization protein 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NRG1 neuregulin 1
NTS neurotensin
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PDGFD platelet derived growth factor D
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PGF placental growth factor
PI3 peptidase inhibitor 3, skin-derived
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAU plasminogen activator, urokinase
PLCG1 phospholipase C, gamma 1
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRL prolactin
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAP1A RAP1A, member of RAS oncogene family
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELN reelin
RPTOR regulatory associated protein of MTOR, complex 1
S1PR1 sphingosine-1-phosphate receptor 1
SCARB1 scavenger receptor class B, member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNAI2 snail family zinc finger 2
SOD1 superoxide dismutase 1, soluble
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYK spleen tyrosine kinase
TFR2 transferrin receptor 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP1 TIMP metallopeptidase inhibitor 1
TNF tumor necrosis factor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP63 tumor protein p63
TSC2 tuberous sclerosis 2
TXNIP thioredoxin interacting protein
TYRP1 tyrosinase-related protein 1
VTN vitronectin