pias1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description protein inhibitor of activated STAT, 1|This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8554)
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Genes

35 genes co-occuring with the biological term pias1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AIRE autoimmune regulator
CASP8AP2 caspase 8 associated protein 2
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
DAXX death-domain associated protein
DNM1 dynamin 1
FOXL2 forkhead box L2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA4 GATA binding protein 4
GRM8 glutamate receptor, metabotropic 8
HES1 hes family bHLH transcription factor 1
IRF3 interferon regulatory factor 3
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF5 Kruppel-like factor 5 (intestinal)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MSX1 msh homeobox 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NCOA3 nuclear receptor coactivator 3
NOS2 nitric oxide synthase 2, inducible
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR5A1 nuclear receptor subfamily 5, group A, member 1
PIAS1 protein inhibitor of activated STAT, 1
PML promyelocytic leukemia
SATB1 SATB homeobox 1
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SOCS3 suppressor of cytokine signaling 3
STAT1 signal transducer and activator of transcription 1, 91kDa
SUMO1 small ubiquitin-like modifier 1
TP53 tumor protein p53
TP73 tumor protein p73
UBE2I ubiquitin-conjugating enzyme E2I
ZMYND11 zinc finger, MYND-type containing 11
ZNF133 zinc finger protein 133