pias3 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description protein inhibitor of activated STAT, 3|This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10401)
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Genes

24 genes co-occuring with the biological term pias3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AR androgen receptor
ATF1 activating transcription factor 1
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
ETV6 ets variant 6
FTMT ferritin mitochondrial
GATA1 GATA binding protein 1 (globin transcription factor 1)
IFNG interferon, gamma
IL12A interleukin 12A
NCAM1 neural cell adhesion molecule 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
PIAS1 protein inhibitor of activated STAT, 1
PIAS3 protein inhibitor of activated STAT, 3
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
SMAD3 SMAD family member 3
SOCS3 suppressor of cytokine signaling 3
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TP53 tumor protein p53
TRIM32 tripartite motif containing 32
TRIM8 tripartite motif containing 8
UBE2I ubiquitin-conjugating enzyme E2I
VIM vimentin
ZFHX3 zinc finger homeobox 3
ZMIZ2 zinc finger, MIZ-type containing 2