picrotoxinin-4260 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the picrotoxinin-4260 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACRV1 acrosomal vesicle protein 1
ADAM22 ADAM metallopeptidase domain 22
ADRA1A adrenoceptor alpha 1A
AFF2 AF4/FMR2 family, member 2
AGXT alanine-glyoxylate aminotransferase
ALPI alkaline phosphatase, intestinal
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
ARSD arylsulfatase D
ASCL1 achaete-scute family bHLH transcription factor 1
C16ORF70 chromosome 16 open reading frame 70
C1QL1 complement component 1, q subcomponent-like 1
CNTNAP2 contactin associated protein-like 2
COL9A3 collagen, type IX, alpha 3
CSN2 casein beta
CSPG4 chondroitin sulfate proteoglycan 4
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DLC1 DLC1 Rho GTPase activating protein
DSC1 desmocollin 1
FAM149A family with sequence similarity 149, member A
FOXD3 forkhead box D3
FOXN3 forkhead box N3
FSCN2 fascin actin-bundling protein 2, retinal
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GPR135 G protein-coupled receptor 135
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIK5 glutamate receptor, ionotropic, kainate 5
GULP1 GULP, engulfment adaptor PTB domain containing 1
HGD homogentisate 1,2-dioxygenase
HIST1H2BL histone cluster 1, H2bl
HRG histidine-rich glycoprotein
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IAPP islet amyloid polypeptide
IGL immunoglobulin lambda locus
IL1RN interleukin 1 receptor antagonist
INS insulin
IQCA1 IQ motif containing with AAA domain 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KRTAP9-9 keratin associated protein 9-9
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LARP4B La ribonucleoprotein domain family, member 4B
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMOD1 leiomodin 1 (smooth muscle)
MAPRE3 microtubule-associated protein, RP/EB family, member 3
METTL7A methyltransferase like 7A
MUC3B mucin 3B, cell surface associated
NEK9 NIMA-related kinase 9
NF1 neurofibromin 1
NPPB natriuretic peptide B
NPR1 natriuretic peptide receptor 1
NRXN3 neurexin 3
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OLFM4 olfactomedin 4
OPRD1 opioid receptor, delta 1
PACRG PARK2 co-regulated
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PKNOX1 PBX/knotted 1 homeobox 1
PLA2G5 phospholipase A2, group V
PLN phospholamban
PRB1 proline-rich protein BstNI subfamily 1
PRRX2 paired related homeobox 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PTTG2 pituitary tumor-transforming 2
RAG2 recombination activating gene 2
RASA3 RAS p21 protein activator 3
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RBM12B RNA binding motif protein 12B
RGS14 regulator of G-protein signaling 14
RHO rhodopsin
SAGE1 sarcoma antigen 1
SEC14L4 SEC14-like 4 (S. cerevisiae)
SFRP5 secreted frizzled-related protein 5
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SOX5 SRY (sex determining region Y)-box 5
SPAG6 sperm associated antigen 6
SVIL supervillin
SYCP1 synaptonemal complex protein 1
SYT13 synaptotagmin XIII
TF transferrin
TJP3 tight junction protein 3
TLE2 transducin-like enhancer of split 2
TMEM59L transmembrane protein 59-like
TNK2 tyrosine kinase, non-receptor, 2
TP53I11 tumor protein p53 inducible protein 11
TRD T cell receptor delta locus
TRGV5 T cell receptor gamma variable 5
TRIM31 tripartite motif containing 31
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
ZMAT4 zinc finger, matrin-type 4
ZNF484 zinc finger protein 484
ZNF814 zinc finger protein 814

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACTG2 actin, gamma 2, smooth muscle, enteric
AOC2 amine oxidase, copper containing 2 (retina-specific)
ARHGAP10 Rho GTPase activating protein 10
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARL14 ADP-ribosylation factor-like 14
ARL15 ADP-ribosylation factor-like 15
ATF7IP2 activating transcription factor 7 interacting protein 2
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BGLAP bone gamma-carboxyglutamate (gla) protein
BNC1 basonuclin 1
C11ORF30 chromosome 11 open reading frame 30
C1QTNF1 C1q and tumor necrosis factor related protein 1
C4ORF29 chromosome 4 open reading frame 29
CCDC85C coiled-coil domain containing 85C
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CEP112 centrosomal protein 112kDa
CIDEB cell death-inducing DFFA-like effector b
CNIH3 cornichon family AMPA receptor auxiliary protein 3
COCH cochlin
CSRNP3 cysteine-serine-rich nuclear protein 3
CUZD1 CUB and zona pellucida-like domains 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DENND4A DENN/MADD domain containing 4A
DNM3 dynamin 3
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EDN1 endothelin 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAM184A family with sequence similarity 184, member A
FAM186A family with sequence similarity 186, member A
FAM69A family with sequence similarity 69, member A
FBXL7 F-box and leucine-rich repeat protein 7
FOXO1 forkhead box O1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GID4 GID complex subunit 4
GPATCH2L G patch domain containing 2-like
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1D histone cluster 1, H1d
HMHA1 histocompatibility (minor) HA-1
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA1462 KIAA1462
LINC00597 long intergenic non-protein coding RNA 597
LMO7 LIM domain 7
LOC100286895 cell division cycle 27 homolog pseudogene
LOC730101 uncharacterized LOC730101
LTBP2 latent transforming growth factor beta binding protein 2
MBTD1 mbt domain containing 1
MYO15A myosin XVA
NDP Norrie disease (pseudoglioma)
NOD1 nucleotide-binding oligomerization domain containing 1
NPIPB3 nuclear pore complex interacting protein family, member B3
OSR2 odd-skipped related transciption factor 2
PALMD palmdelphin
PER3 period circadian clock 3
PGPEP1 pyroglutamyl-peptidase I
PLA2G15 phospholipase A2, group XV
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLXNB3 plexin B3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRPH peripherin
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK7 protein tyrosine kinase 7 (inactive)
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RPL23AP32 ribosomal protein L23a pseudogene 32
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SHROOM2 shroom family member 2
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLMO1 slowmo homolog 1 (Drosophila)
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPEG SPEG complex locus
TAGLN3 transgelin 3
TEX40 testis expressed 40
TM6SF1 transmembrane 6 superfamily member 1
TMEM132A transmembrane protein 132A
TMEM242 transmembrane protein 242
TRAPPC13 trafficking protein particle complex 13
TSPAN8 tetraspanin 8
TXLNG taxilin gamma
UGT8 UDP glycosyltransferase 8
XPA xeroderma pigmentosum, complementation group A
YY2 YY2 transcription factor
ZNF10 zinc finger protein 10
ZNF273 zinc finger protein 273
ZNF286A zinc finger protein 286A
ZNF33B zinc finger protein 33B
ZNF34 zinc finger protein 34
ZNF492 zinc finger protein 492
ZNF76 zinc finger protein 76
ZNF767P zinc finger family member 767, pseudogene
ZNF778 zinc finger protein 778