pik3ca Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha|Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5290)
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Genes

61 genes co-occuring with the biological term pik3ca in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALK anaplastic lymphoma receptor tyrosine kinase
APC adenomatous polyposis coli
ARID1A AT rich interactive domain 1A (SWI-like)
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA2 breast cancer 2, early onset
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN2A cyclin-dependent kinase inhibitor 2A
CLDN2 claudin 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DLC1 DLC1 Rho GTPase activating protein
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
FASLG Fas ligand (TNF superfamily, member 6)
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FOXP1 forkhead box P1
HRAS Harvey rat sarcoma viral oncogene homolog
IGF1R insulin-like growth factor 1 receptor
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JAK2 Janus kinase 2
KEAP1 kelch-like ECH-associated protein 1
KMT2D lysine (K)-specific methyltransferase 2D
KRAS Kirsten rat sarcoma viral oncogene homolog
MGMT O-6-methylguanine-DNA methyltransferase
MIR1-1 microRNA 1-1
MIR1-2 microRNA 1-2
MIR124-1 microRNA 124-1
MIR375 microRNA 375
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MSH2 mutS homolog 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L2 nuclear factor, erythroid 2-like 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PAX6 paired box 6
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
SGK3 serum/glucocorticoid regulated kinase family, member 3
STMN1 stathmin 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
WNT5A wingless-type MMTV integration site family, member 5A