pilocarpine-3300 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the pilocarpine-3300 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ADAP2 ArfGAP with dual PH domains 2
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AGFG2 ArfGAP with FG repeats 2
AIF1 allograft inflammatory factor 1
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
ANXA2P3 annexin A2 pseudogene 3
ARL4D ADP-ribosylation factor-like 4D
ARTN artemin
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BBS9 Bardet-Biedl syndrome 9
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C10ORF12 chromosome 10 open reading frame 12
CDK19 cyclin-dependent kinase 19
CDYL chromodomain protein, Y-like
CFAP45 cilia and flagella associated protein 45
CNOT3 CCR4-NOT transcription complex, subunit 3
CORT cortistatin
CXCR2 chemokine (C-X-C motif) receptor 2
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DNALI1 dynein, axonemal, light intermediate chain 1
DNASE1 deoxyribonuclease I
DOCK4 dedicator of cytokinesis 4
DUSP9 dual specificity phosphatase 9
EMP3 epithelial membrane protein 3
EPHB2 EPH receptor B2
EPS8L1 EPS8-like 1
FAM46C family with sequence similarity 46, member C
FBXO2 F-box protein 2
FOXN3 forkhead box N3
GK glycerol kinase
GPR161 G protein-coupled receptor 161
GRK5 G protein-coupled receptor kinase 5
GRM8 glutamate receptor, metabotropic 8
GSAP gamma-secretase activating protein
HDAC7 histone deacetylase 7
HOXA11 homeobox A11
HOXA9 homeobox A9
IL1B interleukin 1, beta
ING2 inhibitor of growth family, member 2
KEL Kell blood group, metallo-endopeptidase
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KHSRP KH-type splicing regulatory protein
KIAA1107 KIAA1107
KIF13A kinesin family member 13A
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MED1 mediator complex subunit 1
MED16 mediator complex subunit 16
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMRN2 multimerin 2
MR1 major histocompatibility complex, class I-related
MTL5 metallothionein-like 5, testis-specific (tesmin)
MUC3B mucin 3B, cell surface associated
OR10J1 olfactory receptor, family 10, subfamily J, member 1
OSBPL10 oxysterol binding protein-like 10
PCDHA5 protocadherin alpha 5
PDLIM4 PDZ and LIM domain 4
PEX26 peroxisomal biogenesis factor 26
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKNOX1 PBX/knotted 1 homeobox 1
PPT2 palmitoyl-protein thioesterase 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RAB40C RAB40C, member RAS oncogene family
RAD51B RAD51 paralog B
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RBMS2 RNA binding motif, single stranded interacting protein 2
REM1 RAS (RAD and GEM)-like GTP-binding 1
RHOH ras homolog family member H
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RUNX1 runt-related transcription factor 1
S100A8 S100 calcium binding protein A8
SERHL2 serine hydrolase-like 2
SKI SKI proto-oncogene
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SPDEF SAM pointed domain containing ETS transcription factor
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPINK4 serine peptidase inhibitor, Kazal type 4
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TARP TCR gamma alternate reading frame protein
TIMP3 TIMP metallopeptidase inhibitor 3
TLE4 transducin-like enhancer of split 4
TMPO thymopoietin
TRAIP TRAF interacting protein
TRIB2 tribbles pseudokinase 2
TRIO trio Rho guanine nucleotide exchange factor
VEZT vezatin, adherens junctions transmembrane protein
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WNT10B wingless-type MMTV integration site family, member 10B
YIPF4 Yip1 domain family, member 4
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF518A zinc finger protein 518A
ZNF862 zinc finger protein 862
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACTL8 actin-like 8
ADM adrenomedullin
ADTRP androgen-dependent TFPI-regulating protein
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BTF3P12 basic transcription factor 3 pseudogene 12
C11ORF63 chromosome 11 open reading frame 63
C7ORF43 chromosome 7 open reading frame 43
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CALCOCO1 calcium binding and coiled-coil domain 1
CAPN5 calpain 5
CDK3 cyclin-dependent kinase 3
CDKN2AIP CDKN2A interacting protein
CIDEB cell death-inducing DFFA-like effector b
CLCF1 cardiotrophin-like cytokine factor 1
COPZ2 coatomer protein complex, subunit zeta 2
CORO7 coronin 7
CRYBB2P1 crystallin, beta B2 pseudogene 1
CST6 cystatin E/M
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTSF cathepsin F
DAGLA diacylglycerol lipase, alpha
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DVL1 dishevelled segment polarity protein 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ERCC6 excision repair cross-complementation group 6
FAM189A2 family with sequence similarity 189, member A2
FBXO22 F-box protein 22
FGGY FGGY carbohydrate kinase domain containing
FLCN folliculin
GEMIN8 gem (nuclear organelle) associated protein 8
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNL1 guanine nucleotide binding protein-like 1
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H2AI histone cluster 1, H2ai
HIST1H2BJ histone cluster 1, H2bj
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DMA major histocompatibility complex, class II, DM alpha
HOXC10 homeobox C10
IDI2-AS1 IDI2 antisense RNA 1
IFI6 interferon, alpha-inducible protein 6
INF2 inverted formin, FH2 and WH2 domain containing
ITGA10 integrin, alpha 10
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
LAMP3 lysosomal-associated membrane protein 3
LARP6 La ribonucleoprotein domain family, member 6
LINC00339 long intergenic non-protein coding RNA 339
LTC4S leukotriene C4 synthase
LY6D lymphocyte antigen 6 complex, locus D
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MEFV Mediterranean fever
MMP2 matrix metallopeptidase 2
MRPL44 mitochondrial ribosomal protein L44
MT1HL1 metallothionein 1H-like 1
MUC3A mucin 3A, cell surface associated
NDE1 nudE neurodevelopment protein 1
NRGN neurogranin (protein kinase C substrate, RC3)
NRTN neurturin
OCLM oculomedin
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PCDHB13 protocadherin beta 13
PCDHGB5 protocadherin gamma subfamily B, 5
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLAC1 placenta-specific 1
PLXNA3 plexin A3
POLH polymerase (DNA directed), eta
POTEKP POTE ankyrin domain family, member K, pseudogene
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RAB3A RAB3A, member RAS oncogene family
RIN2 Ras and Rab interactor 2
RNF2 ring finger protein 2
RNF39 ring finger protein 39
RNF43 ring finger protein 43
RPGR retinitis pigmentosa GTPase regulator
SCN1B sodium channel, voltage gated, type I beta subunit
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLPI secretory leukocyte peptidase inhibitor
SMIM14 small integral membrane protein 14
SP1 Sp1 transcription factor
SPIDR scaffolding protein involved in DNA repair
STRA6 stimulated by retinoic acid 6
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TDRD1 tudor domain containing 1
TEX40 testis expressed 40
TLN1 talin 1
TMEM183A transmembrane protein 183A
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TUBA3D tubulin, alpha 3d
USB1 U6 snRNA biogenesis 1
VIPR1 vasoactive intestinal peptide receptor 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF137P zinc finger protein 137, pseudogene
ZNF205 zinc finger protein 205
ZNF480 zinc finger protein 480
ZNF532 zinc finger protein 532