pilocarpine-6741 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the pilocarpine-6741 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADAM22 ADAM metallopeptidase domain 22
ADORA3 adenosine A3 receptor
ADRA1B adrenoceptor alpha 1B
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ATF6B activating transcription factor 6 beta
AURKA aurora kinase A
BCAS1 breast carcinoma amplified sequence 1
BICC1 BicC family RNA binding protein 1
BTN3A1 butyrophilin, subfamily 3, member A1
C11ORF30 chromosome 11 open reading frame 30
C14ORF79 chromosome 14 open reading frame 79
C9ORF156 chromosome 9 open reading frame 156
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR7 chemokine (C-C motif) receptor 7
CD28 CD28 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CD8B CD8b molecule
CDK6 cyclin-dependent kinase 6
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CLCA2 chloride channel accessory 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL14A1 collagen, type XIV, alpha 1
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CORO2B coronin, actin binding protein, 2B
CXCL5 chemokine (C-X-C motif) ligand 5
DHRS7 dehydrogenase/reductase (SDR family) member 7
DOC2B double C2-like domains, beta
ELOVL5 ELOVL fatty acid elongase 5
ETV6 ets variant 6
EYA4 EYA transcriptional coactivator and phosphatase 4
FMOD fibromodulin
FOXN2 forkhead box N2
FOXO4 forkhead box O4
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPR161 G protein-coupled receptor 161
GUK1 guanylate kinase 1
HIRA histone cell cycle regulator
HRG histidine-rich glycoprotein
HRH3 histamine receptor H3
ICOSLG inducible T-cell co-stimulator ligand
IGSF1 immunoglobulin superfamily, member 1
IL11 interleukin 11
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KIF21B kinesin family member 21B
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LGALS8 lectin, galactoside-binding, soluble, 8
LHX1 LIM homeobox 1
MFAP3L microfibrillar-associated protein 3-like
MST1 macrophage stimulating 1
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NF1 neurofibromin 1
OSGIN2 oxidative stress induced growth inhibitor family member 2
PAQR5 progestin and adipoQ receptor family member V
PARP11 poly (ADP-ribose) polymerase family, member 11
PARVA parvin, alpha
PDCD2 programmed cell death 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLXNA2 plexin A2
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POM121L2 POM121 transmembrane nucleoporin-like 2
POU6F2 POU class 6 homeobox 2
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRKCE protein kinase C, epsilon
PRUNE2 prune homolog 2 (Drosophila)
PVT1 Pvt1 oncogene (non-protein coding)
RIMS1 regulating synaptic membrane exocytosis 1
RIN3 Ras and Rab interactor 3
SCAND2P SCAN domain containing 2 pseudogene
SH2D1A SH2 domain containing 1A
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SIRT4 sirtuin 4
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SOCS3 suppressor of cytokine signaling 3
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SSTR4 somatostatin receptor 4
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STAB1 stabilin 1
STX7 syntaxin 7
SUGP1 SURP and G patch domain containing 1
SYT17 synaptotagmin XVII
TBXA2R thromboxane A2 receptor
TCF4 transcription factor 4
TGFB1 transforming growth factor, beta 1
THRAP3 thyroid hormone receptor associated protein 3
TPM3 tropomyosin 3
TTC30A tetratricopeptide repeat domain 30A
UBE3A ubiquitin protein ligase E3A
WSB1 WD repeat and SOCS box containing 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZC3H7B zinc finger CCCH-type containing 7B
ZHX3 zinc fingers and homeoboxes 3
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
APOC4 apolipoprotein C-IV
APOL6 apolipoprotein L, 6
ARMC6 armadillo repeat containing 6
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CADPS2 Ca++-dependent secretion activator 2
CASP5 caspase 5, apoptosis-related cysteine peptidase
CD3D CD3d molecule, delta (CD3-TCR complex)
CHMP6 charged multivesicular body protein 6
CIDEC cell death-inducing DFFA-like effector c
CLDN15 claudin 15
CPZ carboxypeptidase Z
DCSTAMP dendrocyte expressed seven transmembrane protein
DNM3 dynamin 3
FAM188A family with sequence similarity 188, member A
FLT4 fms-related tyrosine kinase 4
FRMD8 FERM domain containing 8
FRS3 fibroblast growth factor receptor substrate 3
FSTL3 follistatin-like 3 (secreted glycoprotein)
GALK1 galactokinase 1
GMPR guanosine monophosphate reductase
GPC3 glypican 3
GRAMD1C GRAM domain containing 1C
GRAMD4 GRAM domain containing 4
GREB1L growth regulation by estrogen in breast cancer-like
GRM4 glutamate receptor, metabotropic 4
HDAC11 histone deacetylase 11
HDAC7 histone deacetylase 7
HIST1H1T histone cluster 1, H1t
HIST1H2BN histone cluster 1, H2bn
HIST1H3C histone cluster 1, H3c
HOXC10 homeobox C10
HOXC4 homeobox C4
HSPA1L heat shock 70kDa protein 1-like
IFI6 interferon, alpha-inducible protein 6
IL15RA interleukin 15 receptor, alpha
IL36RN interleukin 36 receptor antagonist
ITGB7 integrin, beta 7
JUNB jun B proto-oncogene
KIAA1549L KIAA1549-like
KLHL26 kelch-like family member 26
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LIME1 Lck interacting transmembrane adaptor 1
LIMS2 LIM and senescent cell antigen-like domains 2
LINC00115 long intergenic non-protein coding RNA 115
LINC00341 long intergenic non-protein coding RNA 341
LINS lines homolog (Drosophila)
LRRK1 leucine-rich repeat kinase 1
LY6D lymphocyte antigen 6 complex, locus D
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MUC3B mucin 3B, cell surface associated
NPM3 nucleophosmin/nucleoplasmin 3
NT5M 5',3'-nucleotidase, mitochondrial
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PAQR6 progestin and adipoQ receptor family member VI
PARM1 prostate androgen-regulated mucin-like protein 1
PCDH12 protocadherin 12
PDE8B phosphodiesterase 8B
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PID1 phosphotyrosine interaction domain containing 1
PKD2L2 polycystic kidney disease 2-like 2
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLXNA3 plexin A3
PRICKLE3 prickle homolog 3 (Drosophila)
PRR7 proline rich 7 (synaptic)
PTPRS protein tyrosine phosphatase, receptor type, S
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPGRIP1L RPGRIP1-like
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCG2 secretogranin II
SLC12A8 solute carrier family 12, member 8
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMR3A submaxillary gland androgen regulated protein 3A
SSBP3 single stranded DNA binding protein 3
STEAP4 STEAP family member 4
STK16 serine/threonine kinase 16
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TBC1D22B TBC1 domain family, member 22B
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TUBA3C tubulin, alpha 3c
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UGT8 UDP glycosyltransferase 8
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VEGFB vascular endothelial growth factor B
VWA1 von Willebrand factor A domain containing 1
WDR4 WD repeat domain 4
WNT1 wingless-type MMTV integration site family, member 1
XYLT2 xylosyltransferase II
YY2 YY2 transcription factor
ZNF253 zinc finger protein 253
ZNF408 zinc finger protein 408
ZNF415 zinc finger protein 415
ZNF778 zinc finger protein 778
ZNF84 zinc finger protein 84