pimethixene-2395 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the pimethixene-2395 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
AGTR1 angiotensin II receptor, type 1
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ALX3 ALX homeobox 3
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARG2 arginase 2
ARNT aryl hydrocarbon receptor nuclear translocator
ATAT1 alpha tubulin acetyltransferase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCAR3 breast cancer anti-estrogen resistance 3
BNC2 basonuclin 2
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CBR3 carbonyl reductase 3
CCDC57 coiled-coil domain containing 57
CD58 CD58 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDRT1 CMT1A duplicated region transcript 1
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CREM cAMP responsive element modulator
CXCL12 chemokine (C-X-C motif) ligand 12
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
DOCK6 dedicator of cytokinesis 6
EN1 engrailed homeobox 1
FAM214B family with sequence similarity 214, member B
FOXD2 forkhead box D2
GAB1 GRB2-associated binding protein 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GSTA3 glutathione S-transferase alpha 3
GSTT1 glutathione S-transferase theta 1
HCRTR2 hypocretin (orexin) receptor 2
HIST1H2BN histone cluster 1, H2bn
HOXB3 homeobox B3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICA1 islet cell autoantigen 1, 69kDa
ING2 inhibitor of growth family, member 2
KCNIP1 Kv channel interacting protein 1
KCTD2 potassium channel tetramerization domain containing 2
KIAA1109 KIAA1109
KIF3C kinesin family member 3C
KLF12 Kruppel-like factor 12
KLRF1 killer cell lectin-like receptor subfamily F, member 1
LGSN lengsin, lens protein with glutamine synthetase domain
LIMS2 LIM and senescent cell antigen-like domains 2
LOC441601 septin 7 pseudogene
LPAR1 lysophosphatidic acid receptor 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MTMR8 myotubularin related protein 8
MTSS1L metastasis suppressor 1-like
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NOP16 NOP16 nucleolar protein
NOTCH4 notch 4
NPPA natriuretic peptide A
NPR1 natriuretic peptide receptor 1
NR5A2 nuclear receptor subfamily 5, group A, member 2
NXPE3 neurexophilin and PC-esterase domain family, member 3
OCA2 oculocutaneous albinism II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE8B phosphodiesterase 8B
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLEK2 pleckstrin 2
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POU2F2 POU class 2 homeobox 2
PRDM1 PR domain containing 1, with ZNF domain
PRKCE protein kinase C, epsilon
PRX periaxin
PTBP3 polypyrimidine tract binding protein 3
PTCRA pre T-cell antigen receptor alpha
PTPRF protein tyrosine phosphatase, receptor type, F
PYGB phosphorylase, glycogen; brain
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RGS3 regulator of G-protein signaling 3
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPL10 ribosomal protein L10
RRAS related RAS viral (r-ras) oncogene homolog
RTEL1 regulator of telomere elongation helicase 1
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SOD3 superoxide dismutase 3, extracellular
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SSX3 synovial sarcoma, X breakpoint 3
TEX15 testis expressed 15
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNNT2 troponin T type 2 (cardiac)
TPST1 tyrosylprotein sulfotransferase 1
VCL vinculin
VEGFC vascular endothelial growth factor C
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF440 zinc finger protein 440
ZNF695 zinc finger protein 695

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACP6 acid phosphatase 6, lysophosphatidic
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANO10 anoctamin 10
ANP32A-IT1 ANP32A intronic transcript 1
AOAH acyloxyacyl hydrolase (neutrophil)
APOLD1 apolipoprotein L domain containing 1
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
BAHD1 bromo adjacent homology domain containing 1
BCKDK branched chain ketoacid dehydrogenase kinase
BPI bactericidal/permeability-increasing protein
BRAF B-Raf proto-oncogene, serine/threonine kinase
C1ORF95 chromosome 1 open reading frame 95
C4ORF29 chromosome 4 open reading frame 29
CAPN15 calpain 15
CCDC71 coiled-coil domain containing 71
CCNT1 cyclin T1
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD82 CD82 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CECR1 cat eye syndrome chromosome region, candidate 1
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
COLEC10 collectin sub-family member 10 (C-type lectin)
CPTP ceramide-1-phosphate transfer protein
CTSK cathepsin K
DDB2 damage-specific DNA binding protein 2, 48kDa
DENND4C DENN/MADD domain containing 4C
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
FAM163A family with sequence similarity 163, member A
FAM188A family with sequence similarity 188, member A
FAM50B family with sequence similarity 50, member B
FANCC Fanconi anemia, complementation group C
FANCF Fanconi anemia, complementation group F
FHL3 four and a half LIM domains 3
FOXN2 forkhead box N2
GAB2 GRB2-associated binding protein 2
GAMT guanidinoacetate N-methyltransferase
GIN1 gypsy retrotransposon integrase 1
GMPPB GDP-mannose pyrophosphorylase B
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GSTCD glutathione S-transferase, C-terminal domain containing
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BE histone cluster 1, H2be
HOPX HOP homeobox
IL18 interleukin 18
IPO8 importin 8
IRAK4 interleukin-1 receptor-associated kinase 4
ISG15 ISG15 ubiquitin-like modifier
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KIAA0753 KIAA0753
KIZ kizuna centrosomal protein
KRI1 KRI1 homolog (S. cerevisiae)
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LAX1 lymphocyte transmembrane adaptor 1
MAGEF1 melanoma antigen family F1
MAPK3 mitogen-activated protein kinase 3
MXD3 MAX dimerization protein 3
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NOL10 nucleolar protein 10
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PGPEP1 pyroglutamyl-peptidase I
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POMZP3 POM121 and ZP3 fusion
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PYCRL pyrroline-5-carboxylate reductase-like
RARS arginyl-tRNA synthetase
RASA2 RAS p21 protein activator 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNASE3 ribonuclease, RNase A family, 3
RNF31 ring finger protein 31
SAV1 salvador family WW domain containing protein 1
SCAI suppressor of cancer cell invasion
SCML1 sex comb on midleg-like 1 (Drosophila)
SEC31B SEC31 homolog B (S. cerevisiae)
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SHPK sedoheptulokinase
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPON2 spondin 2, extracellular matrix protein
SREK1IP1 SREK1-interacting protein 1
SUGP1 SURP and G patch domain containing 1
TCTA T-cell leukemia translocation altered
TGM5 transglutaminase 5
TLR1 toll-like receptor 1
TRAC T cell receptor alpha constant
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA3C tubulin, alpha 3c
TXLNG taxilin gamma
ZNF276 zinc finger protein 276
ZNF696 zinc finger protein 696
ZNF747 zinc finger protein 747