pimozide-3178 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the pimozide-3178 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM19 ADAM metallopeptidase domain 19
AKAP13 A kinase (PRKA) anchor protein 13
AKAP8L A kinase (PRKA) anchor protein 8-like
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APLP1 amyloid beta (A4) precursor-like protein 1
ATF3 activating transcription factor 3
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL3 B-cell CLL/lymphoma 3
BDKRB2 bradykinin receptor B2
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
CD83 CD83 molecule
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CNTNAP1 contactin associated protein 1
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSF cathepsin F
CTSZ cathepsin Z
CYTH1 cytohesin 1
DCTN1 dynactin 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DMD dystrophin
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOCK5 dedicator of cytokinesis 5
DSG1 desmoglein 1
DUOX1 dual oxidase 1
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EFS embryonal Fyn-associated substrate
EGR1 early growth response 1
EGR2 early growth response 2
EGR4 early growth response 4
EMILIN1 elastin microfibril interfacer 1
ERO1LB ERO1-like beta (S. cerevisiae)
FAM182B family with sequence similarity 182, member B
FBN1 fibrillin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GRPR gastrin-releasing peptide receptor
HBEGF heparin-binding EGF-like growth factor
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H2BJ histone cluster 1, H2bj
HIST1H3B histone cluster 1, H3b
HNF4A hepatocyte nuclear factor 4, alpha
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
IL6 interleukin 6
INHBE inhibin, beta E
INO80D INO80 complex subunit D
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
JUN jun proto-oncogene
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KLF6 Kruppel-like factor 6
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LECT2 leukocyte cell-derived chemotaxin 2
LMF2 lipase maturation factor 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK10 mitogen-activated protein kinase 10
MBL2 mannose-binding lectin (protein C) 2, soluble
MCAM melanoma cell adhesion molecule
MIA3 melanoma inhibitory activity family, member 3
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRL neural retina leucine zipper
OASL 2'-5'-oligoadenylate synthetase-like
OCM2 oncomodulin 2
OSGIN1 oxidative stress induced growth inhibitor 1
PDLIM4 PDZ and LIM domain 4
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRL prolactin
RBM48 RNA binding motif protein 48
RCAN1 regulator of calcineurin 1
RND1 Rho family GTPase 1
SCG2 secretogranin II
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4C1 solute carrier organic anion transporter family, member 4C1
TBX21 T-box 21
TFR2 transferrin receptor 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRD T cell receptor delta locus
TRIO trio Rho guanine nucleotide exchange factor
VCX2 variable charge, X-linked 2
VEGFA vascular endothelial growth factor A
ZBTB7A zinc finger and BTB domain containing 7A
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
ACTG2 actin, gamma 2, smooth muscle, enteric
AFAP1 actin filament associated protein 1
AHCYL2 adenosylhomocysteinase-like 2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANXA2P3 annexin A2 pseudogene 3
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
BCORL1 BCL6 corepressor-like 1
BMP4 bone morphogenetic protein 4
C7ORF43 chromosome 7 open reading frame 43
CAMK1 calcium/calmodulin-dependent protein kinase I
CAMKV CaM kinase-like vesicle-associated
CCDC132 coiled-coil domain containing 132
CCDC88C coiled-coil domain containing 88C
CD82 CD82 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CST6 cystatin E/M
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DBR1 debranching RNA lariats 1
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DMTN dematin actin binding protein
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
DYSF dysferlin
EIF5A2 eukaryotic translation initiation factor 5A2
ETAA1 Ewing tumor-associated antigen 1
GATA4 GATA binding protein 4
GEMIN8 gem (nuclear organelle) associated protein 8
GMPR guanosine monophosphate reductase
GPRASP1 G protein-coupled receptor associated sorting protein 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HSPA2 heat shock 70kDa protein 2
IFT54 intraflagellar transport 54
KIAA1456 KIAA1456
KIF13A kinesin family member 13A
KLK5 kallikrein-related peptidase 5
KRT83 keratin 83, type II
LAMB3 laminin, beta 3
LDHB lactate dehydrogenase B
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC49 leucine rich repeat containing 49
LYZ lysozyme
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MOCS3 molybdenum cofactor synthesis 3
MPO myeloperoxidase
MXD3 MAX dimerization protein 3
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NLRX1 NLR family member X1
NMU neuromedin U
NPIPB15 nuclear pore complex interacting protein family, member B15
NT5E 5'-nucleotidase, ecto (CD73)
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PCDHA6 protocadherin alpha 6
PCSK7 proprotein convertase subtilisin/kexin type 7
PLA2G10 phospholipase A2, group X
PROCR protein C receptor, endothelial
PTPRG protein tyrosine phosphatase, receptor type, G
PTPRU protein tyrosine phosphatase, receptor type, U
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RIBC2 RIB43A domain with coiled-coils 2
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF2 ring finger protein 2
SKA1 spindle and kinetochore associated complex subunit 1
SLC12A9 solute carrier family 12, member 9
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC35F5 solute carrier family 35, member F5
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMCO4 single-pass membrane protein with coiled-coil domains 4
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SRGN serglycin
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TET3 tet methylcytosine dioxygenase 3
TMEM110 transmembrane protein 110
TMEM115 transmembrane protein 115
TMEM209 transmembrane protein 209
TMSB15A thymosin beta 15a
TRABD TraB domain containing
TRAF5 TNF receptor-associated factor 5
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TUBA3C tubulin, alpha 3c
TXLNG taxilin gamma
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
USP18 ubiquitin specific peptidase 18
WNT10B wingless-type MMTV integration site family, member 10B
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB44 zinc finger and BTB domain containing 44
ZBTB6 zinc finger and BTB domain containing 6
ZNF510 zinc finger protein 510
ZNF668 zinc finger protein 668
ZNF816 zinc finger protein 816