pimozide-6780 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the pimozide-6780 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHNAK AHNAK nucleoprotein
AKAP8L A kinase (PRKA) anchor protein 8-like
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BLZF1 basic leucine zipper nuclear factor 1
BMP1 bone morphogenetic protein 1
C14ORF79 chromosome 14 open reading frame 79
C1ORF54 chromosome 1 open reading frame 54
CACFD1 calcium channel flower domain containing 1
CCL22 chemokine (C-C motif) ligand 22
CCL5 chemokine (C-C motif) ligand 5
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN6 chloride channel, voltage-sensitive 6
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR3 early growth response 3
ETV5 ets variant 5
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BO histone cluster 1, H2bo
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFNB1 interferon, beta 1, fibroblast
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INHBE inhibin, beta E
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LARP6 La ribonucleoprotein domain family, member 6
LIF leukemia inhibitory factor
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LPIN1 lipin 1
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MBNL2 muscleblind-like splicing regulator 2
MMP19 matrix metallopeptidase 19
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
OASL 2'-5'-oligoadenylate synthetase-like
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G3 phospholipase A2, group III
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
RAD51 RAD51 recombinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RCAN1 regulator of calcineurin 1
RND1 Rho family GTPase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SPATA1 spermatogenesis associated 1
SQLE squalene epoxidase
SRCAP Snf2-related CREBBP activator protein
SRPR signal recognition particle receptor (docking protein)
SSPN sarcospan
TIMP3 TIMP metallopeptidase inhibitor 3
TLR2 toll-like receptor 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
UBOX5 U-box domain containing 5
VASH2 vasohibin 2
VEGFA vascular endothelial growth factor A
WDR19 WD repeat domain 19
ZFP36 ZFP36 ring finger protein
ZFYVE9 zinc finger, FYVE domain containing 9
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
AHCTF1 AT hook containing transcription factor 1
ANXA2P3 annexin A2 pseudogene 3
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B9D2 B9 protein domain 2
BAG4 BCL2-associated athanogene 4
BGLAP bone gamma-carboxyglutamate (gla) protein
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C19ORF40 chromosome 19 open reading frame 40
C19ORF73 chromosome 19 open reading frame 73
C1ORF159 chromosome 1 open reading frame 159
CAPG capping protein (actin filament), gelsolin-like
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC134 coiled-coil domain containing 134
CCDC69 coiled-coil domain containing 69
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CGREF1 cell growth regulator with EF-hand domain 1
CLCN2 chloride channel, voltage-sensitive 2
CLSPN claspin
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTSF cathepsin F
CTSK cathepsin K
CTSV cathepsin V
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
EXD3 exonuclease 3'-5' domain containing 3
FXN frataxin
GAMT guanidinoacetate N-methyltransferase
GATA4 GATA binding protein 4
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPR27 G protein-coupled receptor 27
GSTCD glutathione S-transferase, C-terminal domain containing
HDAC4 histone deacetylase 4
HEATR3 HEAT repeat containing 3
HIRA histone cell cycle regulator
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-J major histocompatibility complex, class I, J (pseudogene)
HOXC8 homeobox C8
ICK intestinal cell (MAK-like) kinase
KDM8 lysine (K)-specific demethylase 8
LRP5 low density lipoprotein receptor-related protein 5
MAGEF1 melanoma antigen family F1
MATK megakaryocyte-associated tyrosine kinase
MBIP MAP3K12 binding inhibitory protein 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCC mutated in colorectal cancers
MEFV Mediterranean fever
MGC12488
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit
NDRG1 N-myc downstream regulated 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NT5E 5'-nucleotidase, ecto (CD73)
PADI1 peptidyl arginine deiminase, type I
PCDH12 protocadherin 12
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLA2G12A phospholipase A2, group XIIA
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLXNA3 plexin A3
POMT2 protein-O-mannosyltransferase 2
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPAP1 RNA polymerase II associated protein 1
RPH3AL rabphilin 3A-like (without C2 domains)
RPL23AP7 ribosomal protein L23a pseudogene 7
SCAI suppressor of cancer cell invasion
SDC3 syndecan 3
SECTM1 secreted and transmembrane 1
SIX1 SIX homeobox 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLIT2 slit homolog 2 (Drosophila)
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SMR3A submaxillary gland androgen regulated protein 3A
SOX3 SRY (sex determining region Y)-box 3
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TCHH trichohyalin
TOM1 target of myb1 (chicken)
TRAIP TRAF interacting protein
TRIM5 tripartite motif containing 5
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTBK2 tau tubulin kinase 2
TUBA3C tubulin, alpha 3c
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
URM1 ubiquitin related modifier 1
USB1 U6 snRNA biogenesis 1
VEZT vezatin, adherens junctions transmembrane protein
VGF VGF nerve growth factor inducible
ZNF205 zinc finger protein 205
ZNF253 zinc finger protein 253
ZNF573 zinc finger protein 573
ZNF675 zinc finger protein 675
ZNF767P zinc finger family member 767, pseudogene
ZNF83 zinc finger protein 83