pimozide-7132 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the pimozide-7132 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
AKR1C3 aldo-keto reductase family 1, member C3
ANG angiogenin, ribonuclease, RNase A family, 5
ATF3 activating transcription factor 3
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BCAS3 breast carcinoma amplified sequence 3
C11ORF71 chromosome 11 open reading frame 71
CD40 CD40 molecule, TNF receptor superfamily member 5
CD58 CD58 molecule
CENPJ centromere protein J
CLEC2B C-type lectin domain family 2, member B
COPA coatomer protein complex, subunit alpha
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYB561 cytochrome b561
CYBA cytochrome b-245, alpha polypeptide
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DGCR8 DGCR8 microprocessor complex subunit
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DTNA dystrobrevin, alpha
DTX2 deltex 2, E3 ubiquitin ligase
EFNA5 ephrin-A5
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EML3 echinoderm microtubule associated protein like 3
ERN2 endoplasmic reticulum to nucleus signaling 2
ESR1 estrogen receptor 1
FER1L4 fer-1-like family member 4, pseudogene (functional)
FXYD3 FXYD domain containing ion transport regulator 3
GATA3 GATA binding protein 3
GK glycerol kinase
GLG1 golgi glycoprotein 1
GOLGA2 golgin A2
H2AFX H2A histone family, member X
HAPLN1 hyaluronan and proteoglycan link protein 1
HDAC9 histone deacetylase 9
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HINFP histone H4 transcription factor
HIPK3 homeodomain interacting protein kinase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOMER3 homer scaffolding protein 3
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI44 interferon-induced protein 44
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
METTL7A methyltransferase like 7A
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MFSD11 major facilitator superfamily domain containing 11
MX1 MX dynamin-like GTPase 1
NDE1 nudE neurodevelopment protein 1
NIPBL Nipped-B homolog (Drosophila)
NLRX1 NLR family member X1
NPM3 nucleophosmin/nucleoplasmin 3
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OASL 2'-5'-oligoadenylate synthetase-like
PDGFB platelet-derived growth factor beta polypeptide
PEX5 peroxisomal biogenesis factor 5
PGAP1 post-GPI attachment to proteins 1
PGPEP1 pyroglutamyl-peptidase I
PLXNB1 plexin B1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNPLA4 patatin-like phospholipase domain containing 4
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RGS14 regulator of G-protein signaling 14
SAMD9 sterile alpha motif domain containing 9
SBNO2 strawberry notch homolog 2 (Drosophila)
SHPK sedoheptulokinase
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC48A1 solute carrier family 48 (heme transporter), member 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SOS2 son of sevenless homolog 2 (Drosophila)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRD5A3 steroid 5 alpha-reductase 3
SSH3 slingshot protein phosphatase 3
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYT1 synaptotagmin I
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TRAPPC10 trafficking protein particle complex 10
TRIB3 tribbles pseudokinase 3
TSPAN1 tetraspanin 1
WNT7A wingless-type MMTV integration site family, member 7A
YY2 YY2 transcription factor
ZFPL1 zinc finger protein-like 1
ZNF467 zinc finger protein 467
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AHDC1 AT hook, DNA binding motif, containing 1
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ASS1 argininosuccinate synthase 1
ATAD5 ATPase family, AAA domain containing 5
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BAX BCL2-associated X protein
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2A1 BCL2-related protein A1
BCL9 B-cell CLL/lymphoma 9
C19ORF54 chromosome 19 open reading frame 54
C1ORF35 chromosome 1 open reading frame 35
C5ORF28 chromosome 5 open reading frame 28
CBR4 carbonyl reductase 4
CCNJL cyclin J-like
CHST10 carbohydrate sulfotransferase 10
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CRIP1 cysteine-rich protein 1 (intestinal)
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EVPL envoplakin
FAM86B1 family with sequence similarity 86, member B1
FANCE Fanconi anemia, complementation group E
FCHO1 FCH domain only 1
FGD1 FYVE, RhoGEF and PH domain containing 1
FHOD1 formin homology 2 domain containing 1
FHOD3 formin homology 2 domain containing 3
GAB2 GRB2-associated binding protein 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GRWD1 glutamate-rich WD repeat containing 1
GSR glutathione reductase
HELLS helicase, lymphoid-specific
HIRA histone cell cycle regulator
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HOXC10 homeobox C10
IL4R interleukin 4 receptor
KRT8P12 keratin 8 pseudogene 12
LZTR1 leucine-zipper-like transcription regulator 1
MAST3 microtubule associated serine/threonine kinase 3
MFSD12 major facilitator superfamily domain containing 12
MOB3B MOB kinase activator 3B
MOGS mannosyl-oligosaccharide glucosidase
MON1B MON1 secretory trafficking family member B
MYLK myosin light chain kinase
MYNN myoneurin
NCS1 neuronal calcium sensor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NHLRC2 NHL repeat containing 2
NOL6 nucleolar protein 6 (RNA-associated)
NXPE3 neurexophilin and PC-esterase domain family, member 3
ODF2 outer dense fiber of sperm tails 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRMT7 protein arginine methyltransferase 7
PTK7 protein tyrosine kinase 7 (inactive)
PTTG3P pituitary tumor-transforming 3, pseudogene
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RAB4B RAB4B, member RAS oncogene family
RBL1 retinoblastoma-like 1
RECQL4 RecQ protein-like 4
RINT1 RAD50 interactor 1
ROGDI rogdi homolog (Drosophila)
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SKA1 spindle and kinetochore associated complex subunit 1
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC22A18 solute carrier family 22, member 18
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC41A3 solute carrier family 41, member 3
SLTM SAFB-like, transcription modulator
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNORA21 small nucleolar RNA, H/ACA box 21
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK16 serine/threonine kinase 16
TBC1D10B TBC1 domain family, member 10B
TEAD3 TEA domain family member 3
TGIF2 TGFB-induced factor homeobox 2
TGS1 trimethylguanosine synthase 1
THBS3 thrombospondin 3
THRAP3 thyroid hormone receptor associated protein 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMOD3 tropomodulin 3 (ubiquitous)
TRAIP TRAF interacting protein
TRIM26 tripartite motif containing 26
UNKL unkempt family zinc finger-like
USP6NL USP6 N-terminal like
WBSCR16 Williams-Beuren syndrome chromosome region 16
WDR41 WD repeat domain 41
WWC2 WW and C2 domain containing 2
ZNF787 zinc finger protein 787
ZNF813 zinc finger protein 813