pioglitazone-5925 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the pioglitazone-5925 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
AGER advanced glycosylation end product-specific receptor
AKAP10 A kinase (PRKA) anchor protein 10
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ASIC1 acid sensing (proton gated) ion channel 1
CA5BP1 carbonic anhydrase VB pseudogene 1
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCNT2 cyclin T2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFLAR CASP8 and FADD-like apoptosis regulator
CLGN calmegin
CNPY4 canopy FGF signaling regulator 4
CREB1 cAMP responsive element binding protein 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DGKE diacylglycerol kinase, epsilon 64kDa
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DPF3 D4, zinc and double PHD fingers, family 3
DTNA dystrobrevin, alpha
ELL elongation factor RNA polymerase II
ENGASE endo-beta-N-acetylglucosaminidase
ENOX2 ecto-NOX disulfide-thiol exchanger 2
FBRS fibrosin
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FGFR1 fibroblast growth factor receptor 1
FGFR4 fibroblast growth factor receptor 4
GALK1 galactokinase 1
GAP43 growth associated protein 43
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPATCH3 G patch domain containing 3
GPR137 G protein-coupled receptor 137
GPR157 G protein-coupled receptor 157
GSDMB gasdermin B
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa
HIST1H2BJ histone cluster 1, H2bj
IFNW1 interferon, omega 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INO80B INO80 complex subunit B
KIF22 kinesin family member 22
KRT6B keratin 6B, type II
KRT83 keratin 83, type II
LIMCH1 LIM and calponin homology domains 1
LIME1 Lck interacting transmembrane adaptor 1
LPCAT3 lysophosphatidylcholine acyltransferase 3
LRRC40 leucine rich repeat containing 40
MFAP3 microfibrillar-associated protein 3
MTA1 metastasis associated 1
N4BP1 NEDD4 binding protein 1
NCKIPSD NCK interacting protein with SH3 domain
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOS1 nitric oxide synthase 1 (neuronal)
OGFR opioid growth factor receptor
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE4DIP phosphodiesterase 4D interacting protein
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLEC plectin
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PSG9 pregnancy specific beta-1-glycoprotein 9
RABIF RAB interacting factor
RARA retinoic acid receptor, alpha
RBMS2 RNA binding motif, single stranded interacting protein 2
RPL35A ribosomal protein L35a
RUSC2 RUN and SH3 domain containing 2
S100A8 S100 calcium binding protein A8
SCNN1B sodium channel, non voltage gated 1 beta subunit
SCYL2 SCY1-like 2 (S. cerevisiae)
SECTM1 secreted and transmembrane 1
SIPA1 signal-induced proliferation-associated 1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SND1-IT1 SND1 intronic transcript 1
SOX9 SRY (sex determining region Y)-box 9
SRPR signal recognition particle receptor (docking protein)
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAPBP TAP binding protein (tapasin)
TBX3 T-box 3
TCF25 transcription factor 25 (basic helix-loop-helix)
TCF3 transcription factor 3
TET3 tet methylcytosine dioxygenase 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLR5 toll-like receptor 5
TMEM63A transmembrane protein 63A
TMPRSS2 transmembrane protease, serine 2
TOR1AIP1 torsin A interacting protein 1
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TSC2 tuberous sclerosis 2
TTC38 tetratricopeptide repeat domain 38
U2AF2 U2 small nuclear RNA auxiliary factor 2
UBTD1 ubiquitin domain containing 1
UPK3B uroplakin 3B
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WDR25 WD repeat domain 25
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ADGRG2 adhesion G protein-coupled receptor G2
AFF4 AF4/FMR2 family, member 4
AMPD1 adenosine monophosphate deaminase 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARL15 ADP-ribosylation factor-like 15
ARR3 arrestin 3, retinal (X-arrestin)
ATAT1 alpha tubulin acetyltransferase 1
ATF3 activating transcription factor 3
AVPR1B arginine vasopressin receptor 1B
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BIRC7 baculoviral IAP repeat containing 7
BTF3P12 basic transcription factor 3 pseudogene 12
C1QB complement component 1, q subcomponent, B chain
C7ORF69 chromosome 7 open reading frame 69
CCNJL cyclin J-like
CD79B CD79b molecule, immunoglobulin-associated beta
CDON cell adhesion associated, oncogene regulated
CEMIP cell migration inducing protein, hyaluronan binding
CES3 carboxylesterase 3
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
CLIP4 CAP-GLY domain containing linker protein family, member 4
CNTN5 contactin 5
COL16A1 collagen, type XVI, alpha 1
CSF1R colony stimulating factor 1 receptor
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
DES desmin
DLK1 delta-like 1 homolog (Drosophila)
DNALI1 dynein, axonemal, light intermediate chain 1
DTX2 deltex 2, E3 ubiquitin ligase
F11 coagulation factor XI
FAAH fatty acid amide hydrolase
FAM155A family with sequence similarity 155, member A
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGF4 fibroblast growth factor 4
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GAL3ST4 galactose-3-O-sulfotransferase 4
GIF gastric intrinsic factor (vitamin B synthesis)
GJA8 gap junction protein, alpha 8, 50kDa
GSTTP1 glutathione S-transferase theta pseudogene 1
HAMP hepcidin antimicrobial peptide
HHAT hedgehog acyltransferase
HLA-J major histocompatibility complex, class I, J (pseudogene)
HOXA4 homeobox A4
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IRS4 insulin receptor substrate 4
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCTD17 potassium channel tetramerization domain containing 17
KIAA1456 KIAA1456
KLK5 kallikrein-related peptidase 5
LIMS2 LIM and senescent cell antigen-like domains 2
LRRC20 leucine rich repeat containing 20
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
METTL16 methyltransferase like 16
MORN1 MORN repeat containing 1
MSI1 musashi RNA-binding protein 1
MUC3B mucin 3B, cell surface associated
OLFML2A olfactomedin-like 2A
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PDE9A phosphodiesterase 9A
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PHEX phosphate regulating endopeptidase homolog, X-linked
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PNPLA3 patatin-like phospholipase domain containing 3
POLM polymerase (DNA directed), mu
POMT2 protein-O-mannosyltransferase 2
POU4F2 POU class 4 homeobox 2
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKCE protein kinase C, epsilon
PSG4 pregnancy specific beta-1-glycoprotein 4
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RAB30 RAB30, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RHBG Rh family, B glycoprotein (gene/pseudogene)
ROM1 retinal outer segment membrane protein 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SREK1IP1 SREK1-interacting protein 1
TAS2R3 taste receptor, type 2, member 3
TEX40 testis expressed 40
TRAIP TRAF interacting protein
TRDMT1 tRNA aspartic acid methyltransferase 1
TRIM21 tripartite motif containing 21
TSNAXIP1 translin-associated factor X interacting protein 1
TTLL1 tubulin tyrosine ligase-like family member 1
UCN urocortin
UNC119 unc-119 homolog (C. elegans)
WFDC2 WAP four-disulfide core domain 2
ZFHX4 zinc finger homeobox 4
ZFP30 ZFP30 zinc finger protein
ZNF205 zinc finger protein 205
ZNF358 zinc finger protein 358
ZSCAN2 zinc finger and SCAN domain containing 2